A5058633305- Plant Gene Expression Analysis
- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Biochemical and biochemical processes
- Plant tissue culture and regeneration
- Inorganic Fluorides and Related Compounds
- Colorectal Cancer Treatments and Studies
- Photosynthetic Processes and Mechanisms
- Inorganic Chemistry and Materials
- Colorectal Cancer Screening and Detection
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Fungal and yeast genetics research
- Radiation Therapy and Dosimetry
- Adenosine and Purinergic Signaling
- Enzyme Production and Characterization
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Dental Radiography and Imaging
- Enzyme Catalysis and Immobilization
- Biochemical and Molecular Research
Sun Yat-sen University
2022-2024
Sun Yat-sen University Cancer Center
2022-2024
Chinese Academy of Sciences
2024
Changsha Medical University
2024
University of Jinan
2021-2024
Wuzhou Red Cross Hospital
2024
Huazhong University of Science and Technology
2024
Fujian Medical University
2024
State Key Laboratory of Oncology in South China
2023
Shandong University
2010-2022
FNS I is a 2‐oxoglutarate dependent dioxygenase (2‐ODD) found mainly in species of the Apiaceae family. Here, an cDNA sequence was isolated from liverwort Plagiochasma appendiculatum (Aytoniaceae) and characterized. The recombinant protein exhibited high activity catalyzing conversion naringenin to apigenin 2‐hydroxynaringenin. critical residue for flavanone‐2‐hydroxylation Tyr240, as identified homology modeling site‐directed mutagenesis. also showed some flavonol synthase activity, it can...
The global emergence of antifungal resistance threatens the limited arsenal available treatments and emphasizes urgent need for alternative agents. Targeting fungal pathogenic functions is an appealing therapeutic strategy. Here, we show that cystathionine β-synthase (CBS), compared with γ-lyase, major enzyme synthesizes hydrogen sulfide in fungus Candida albicans . Deletion CBS leads to deficiencies oxidative stress, retarded cell growth, defective hyphal increased β-glucan exposure, which,...
Breast cancer is the most common type of malignancy in women, which remains a significant health concern worldwide. Gemcitabine frequently applied anticancer pharmacological agent. However, efficacy gemcitabine limited by chemoresistance. In present study, combination reverse transcription quantitative-PCR, cell viability, flow cytometry, luciferase reporter assay and western blot analysis were performed to elucidate potential effects miR-187-3p on sensitivity breast line, MDA-MB-231. The...
Alkenal double bond reductases (DBRs) catalyze the NADPH‐dependent reduction of α,β‐unsaturated many secondary metabolites. Two alkenal reductase genes PaDBR1 and PaDBR2 were isolated from liverwort species Plagiochasma appendiculatum . Recombinant protein had a higher catalytic activity than with respect to present in hydroxycinnamyl aldehydes. The residue at position 56 appeared be responsible for this difference enzyme activity. functionality C56 Y56 mutation was similar that PaDBR2....
Abstract Background Standard treatment of locally advanced rectal cancer (LARC) was neoadjuvant chemoradiotherapy (CRT), followed by total mesorectal excision (TME). Total (TNT), a new concept, attempts to deliver both systemic chemotherapy and CRT prior surgery. Patients treated with were more likely show higher tumor regression. The objective this trial increase complete clinical rate (cCR) for LARC patients optimizing response, using TNT regimen as compared conventional chemoradiotherapy....
As very large scale integrated fabrication technology continuously scales down, the requirements for contact tungsten chemical mechanical polishing (CMP) become more and stringent. In this paper, we reported newly observed surface particle defects which were confirmed to be slurry particles or residues. These trapped among W plugs difficult removed with existing cleaning methods chemicals. Consequently, these may give rise shorts between metal 1 (M1) cause severe reliability problems, have...
Background: There is a rapidly increasing incidence of early-onset colorectal cancer (EO-CRC) which threatens the survival young people, while aging also represents challenging clinical problem. Objectives: We aimed to investigate differences in characteristics and prognosis stage III rectal (RC), help optimize treatment strategies. Design methods: This study included 757 patients with RC, all whom received neoadjuvant chemoradiotherapy total mesorectal excision. The whole cohort was...
Volumetric resorption of the alveolar ridge often occurs in both horizontal and vertical directions following tooth extraction. There is a specific lack evidence for reconstruction at molar premolar sites with severe bone resorption. This randomized controlled trial used 3D linear analyses to evaluate volumetric changes (ARR) as compared unassisted socket healing before implant placement. A total 31 patients (15 men, 16 women) > 50% hard tissue loss one or more walls were recruited into...
<title>Abstract</title> Patient-derived cancer organoids emerged as an innovative model in basic and translational medicine research, well precision medicine. However, most radiation oncologists are still unaware of the value oncology especially oncology. The methods for assessment cell death after irradiation was also undefined. In this study, three organoid lines were successfully established from surgical specimens rectal patients. These displayed diverse architecture captured...
<title>Abstract</title> Patient-derived cancer organoids emerged as an innovative model in basic and translational medicine research, well precision medicine. However, most radiation oncologists are still unaware of the value oncology especially oncology. The methods for assessment cell death after irradiation was also undefined. In this study, three organoid lines were successfully established from surgical specimens rectal patients. These displayed diverse architecture captured...
One new eudesmane sesquiterpene 1 and one chromolaevane 2, along with 19 known compounds, have been isolated from the invasive plant Solidago canadensis. Their structures were established by spectroscopic means, including 1D/2D-NMR HR-ESIMS analyses. Compounds 10 12, in combination fluconazole, showed significant activity an vitro synergistic antifungal assay against Candida albicans, FIC values of <0.15625 <0.28125, respectively. Meanwhile, allelopathic effects these sesquiterpenes on...
The pathological T3N0M0 (pT3N0M0) rectal cancer is the earliest stage and has best prognosis in locally advanced cancer, but optimal treatment remains controversial. A reliable prognostic model needed to discriminate high-risk patients from low-risk patients, optimize adjuvant chemotherapy (ACT) decisions by predicting likelihood of ACT benefit for target population.We gathered analyzed 276 Sun Yat-sen University Cancer Center March 2005 December 2011. All underwent total mesorectal excision...
目的 观察小鼠有机磷中毒后肌无力的情况及病理改变.方法 将117只昆明种小鼠分为7个实验组(1～7 d观察组),每组15只,1个正常对照组(6只)及1个生理盐水对照组(6只).对实验组以50 mg/kg氧化乐果腹腔注射染毒(1～7 d);正常对照组不予任何处理;生理盐水对照组给予生理盐水0.9 ml腹腔注射.观察小鼠出现肌无力情况,并留取膈肌和股直肌行HE染色和乙酰胆碱酯酶(AChE)染色,观察肌肉病理改变及运动终板数目及着色变化.结果 105只小鼠急性氧乐果中毒后43只出现肌无力,肌无力发生率40.1%;急性期小鼠死亡7只,死亡率为6.7%;肌无力主要表现为肢体力弱,屈颈肌无力及呼吸困难不明显.肌肉病理染色结果显示,HE染色中实验组肌无力与非肌无力小鼠镜下均呈炎性改变,表现为肌膜核增加,核内移,肌间质炎细胞浸润.肌无力小鼠的肌肉运动终板数目较对照组明显减少,差异有统计学意义(P＜0.05);肌无力组膈肌2、3、7 d和股直肌1、3、5、7 d的运动终板数明显低于非肌无力组,差异有统计学意义(P＜0.05);各时间点肌无力组肌肉的运动终板数差异无统计学意义(P＞0.05).结论...