A5101930672- dental development and anomalies
- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Bone and Dental Protein Studies
- Molecular Biology Techniques and Applications
- Periodontal Regeneration and Treatments
- Cancer-related molecular mechanisms research
- Dental Implant Techniques and Outcomes
- Oral and Maxillofacial Pathology
- Forensic and Genetic Research
- Cleft Lip and Palate Research
- Dental Erosion and Treatment
- Bacteriophages and microbial interactions
- Dental Trauma and Treatments
- Dental materials and restorations
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Temporomandibular Joint Disorders
- Orthodontics and Dentofacial Orthopedics
- Genomics and Phylogenetic Studies
- Mesenchymal stem cell research
- Reconstructive Surgery and Microvascular Techniques
- MicroRNA in disease regulation
- Metabolism and Genetic Disorders
Southern Medical University Shenzhen Hospital
2021-2025
Stomatology Hospital
2010-2025
Southern Medical University
2012-2025
Nanfang Hospital
2009-2025
Air Force Medical University
2004-2009
175th Hospital of People's Liberation Army
2003
Metastasis is an important cause of high mortality and lethality oral cancer. Fusobacterium nucleatum (Fn) can promote tumour metastasis. Outer membrane vesicles (OMVs) are secreted by Fn. However, the effects Fn-derived extracellular on cancer metastasis underlying mechanisms unclear. We aimed to determine whether how Fn OMVs mediate were isolated from brain heart infusion (BHI) broth supernatant ultracentrifugation. Tumour-bearing mice treated with evaluate effect Transwell assays...
Background. Exosomes from human dental pulp stem cells (hDPSCs) were indicated to play a positive role in vascular regeneration processes. But the angiogenic capabilities of exosomes inflammatory hDPSCs and underlying mechanism remain unknown. In this study, factor lipopolysaccharide (LPS) was used stimulate hDPSCs, extracted these hDPSCs. The proangiogenic potential examined, studied. Method. isolated with or without LPS stimulation (N-EXO LPS-EXO) cocultured umbilical vein endothelial...
Background and Objective Oral bacteria can translocate to the intestine, their colonization efficiency is influenced by gastrointestinal tract pH. Understanding how oral resist acidic environments crucial for elucidating role in gut health disease.
The regulation of macrophage polarization by mesenchymal stem cells (MSCs) is a prominent area research but faces challenges due to limited MSC sources and incomplete understanding underlying mechanisms. We sought identify an accessible source investigate how MSCs regulate using high‐throughput sequencing. isolated dental follicle from discarded human third molar follicles cocultured them with THP‐1‐derived macrophages in the conditioned medium. Transcriptome sequencing identified...
Our previous studies have revealed that a dominant mutation in vacuolar protein sorting 4B (VPS4B), member of the AAA ATPase family, causes dentin dysplasia type I. The purpose present study was to investigate roles VPS4B human dental pulp stem cells (hDPSCs) and elucidate underlying molecular mechanisms. In this study, we found highly expressed mouse molar tooth germ, expression increased significantly during odontoblastic differentiation hDPSCs. downregulation inhibited proliferation,...
Ancestry informative markers (AIMs) are useful to infer individual biogeographical ancestry and estimate admixture proportions of admixed populations or individuals. Although a growing number AIM panels for forensic origin analyses were developed, they may not efficiently the origins most in China. In this study, set 52 deletion/insertion polymorphisms (AIDIPs) selected with aim effectively differentiate continental partial Chinese populations. All successfully incorporated into single...
Because of its non-template addition feature, Taq DNA polymerase can catalyze one or more extra nucleotides onto the 3′ terminus PCR products. An peak is observed at DYS391 locus after products stored for 4 days 4°C. To explore formation mechanism this artifact, primers and amplicon sequences Y-STR loci are analyzed, furthermore, storage conditions termination discussed. The a + 2 product, which we call excessive split (EASP). most significant difference between EASP incomplete adenine...
Caesarean-section (C-section) may influence children's long-term health by affecting bacterial colonization. However, few studies have focused on the association between C-section delivery (CSD) and dental caries, previous conclusions been conflicting. This study aimed to explore whether CSD would increase risk of early childhood caries (ECC) in preschool children China.This was a retrospective cohort study. Three-year-old with full primary dentition were included through medical records...
Endocrown restoration is widely used to restore endodontically treated teeth. However, the clinical effects of different computer-aided design/computer-aided manufacturing (CAD/CAM) materials for endocrown are not clear. The primary objective this trial compare efficacy resin-based bloc and ceramic endocrowns restoring teeth.The proposed assessment a parallel group-designed randomized controlled trial. We will recruit 156 adults between 18 75 years old with minimum one such molar. inclusion...
Background. Mutations of the Ectodysplasin-A (EDA) gene are generally associated with syndrome hypohidrotic ectodermal dysplasia or nonsyndromic tooth agenesis. The influence EDA mutations on dentinogenesis and odontoblast differentiation has not been reported. aim this study was to identify genetic clues for causes familial oligodontia explore underlying mechanisms involved, while focusing role human dental pulp stem cells (hDPSCs). Materials Methods. Candidate sequences were obtained by...
In an attempt to increase the discrimination capacity (DC) and reduce adventitious match probability, a 6-dye multiplex Y-chromosomal short tandem repeat (Y-STR) panel named Y34plex was constructed that combined 25 markers (DYS456, DYS627, DYS390, DYS570, DYS635, DYS385a/b, DYS448, DYS437, DYS533, DYS449, DYS481, DYS392, DYS391, DYS389I, DYS460, YGATAH4, DYS438, DYS389II, DYS19, DYS458, DYF387S1a/b, DYS439, DYS393, DYS576, DYS518) in widely used commercial kits, with nine highly polymorphic...
Objective To assess patients' satisfaction level with orthodontic treatment and to identify it there was any association between patient's reason seek their the outcome. Methods This study conducted among a sample of 80 patients. A questionnaire formulated including Dental Impact on Daily Living (to effect daily living dentition). Descriptive statistics, Chi-square test were used analyze data. Results Conclusion Patients' had no significant dentition after...
To explore the histological structure of deciduous teeth and tooth germs Tibetan miniature pigs for studies dental tissue diseases regeneration.The was observed by X-ray. The ultrastructure enamel dentin characterized scanning electron microscopy. jaws were three-dimensionally reconstructed using Mimics software based on Micro-CT teeth. Image J used to calculate gray value mineralization density Hisotological germ pulp HE staining.The composed enamel, medullary tissue. permanent formed...
This study is aimed at comparing the efficacy of heat softening and ultrasonic removal root-end gutta-percha during retrograde preparation for root apical microsurgery. Recently extracted single-rooted premolars (n = 40) were prepared with standardized endodontically treated resection then randomly divided into four groups that received cavity using different instruments: a diamond-coated tip (AS3D; SACTEON, Paris, France), AS3D modified plugger cordless carrier (MSE; B&L Biotech, Bala...
Background: FERM domain-containing protein 4A (FRMD4A) is a scaffolding previously proposed to be critical in the regulation of cell polarity neurons and implicated human intellectual development. Case Presentation: We report case 3-year-old boy with corpus callosum anomaly, relative macrocephaly, ataxia, unexplained global developmental delay. Here, compound heterozygous missense mutations FRMD4A gene [c.1830G>A, p.(Met610Ile) c.2973G>C, p.(Gln991His)] were identified proband, subsequent...
In stomatology, root canal therapy is a commonly used and effective treatment for dental pulp diseases periapical diseases. However, pain may occur during or after severely affect patients. This article aimed to analyze the mechanism cause of therapy, which reduce relieve pain.根管治疗是牙髓病及根尖周病的一种有效治疗方法，已在临床上广泛使用，然而在治疗过程中及治疗完成后患者可能会出现各种原因的疼痛。本文对根管治疗术中疼痛发生的原因进行分析，从而为临床医生采取相应的有效措施和治疗手段缓解患者痛苦提供参考。.