A5032705437- Liver physiology and pathology
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Transplantation: Methods and Outcomes
- Hormonal Regulation and Hypertension
- Pediatric Hepatobiliary Diseases and Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Ethics and Legal Issues in Pediatric Healthcare
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Congenital Anomalies and Fetal Surgery
- Pituitary Gland Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Gallbladder and Bile Duct Disorders
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
Cincinnati Children's Hospital Medical Center
2022-2025
University of Cincinnati Medical Center
2022-2023
Sabin Vaccine Institute
2023
University of Cincinnati
2022
University of Missouri
2019
Washington University in St. Louis
2017
Abstract Uterine serous cancer (USC) is aggressive, and the majority of recurrent cases are chemoresistant. Because receptor tyrosine kinase AXL promotes invasion metastasis USC implicated in chemoresistance other cancers, we assessed role paclitaxel resistance USC, determined mechanism action, sought to restore chemosensitivity by inhibiting vitro vivo. We used short hairpin RNAs BGB324 knock down inhibit AXL. sensitivity cell lines measured intracellular accumulation presence or absence...
Donation after circulatory death (DCD) liver transplantation (LT) has become an effective mechanism for expanding the donor pool and decreasing waitlist mortality. However, it is unclear if low-volume DCD centers can achieve comparable outcomes to high-volume centers.From 2011 2019 utilizing United Network Organ Sharing (UNOS) database, transplant were categorized into tertiles based on their annual volume of LTs. Donor selection, recipient survival compared between very-low (VLV, n = 1-2...
Abstract Background Enhancer of zeste homolog 2 (EZH2) catalyzes the trimethylation histone H3 at lysine 27 via polycomb recessive complex (PRC2) and plays a time‐specific role in normal fetal liver development. EZH2 is overexpressed hepatoblastoma (HB), an embryonal tumor. can also promote tumorigenesis noncanonical, PRC2‐independent mechanism proto‐oncogenic, direct protein interaction, including β‐catenin. We hypothesize that pathological activation contributes to HB propagation manner....
The utilization of minimally invasive surgery (MIS) for adrenocortical carcinoma (ACC) remains controversial due to concerns regarding the quality surgical resection and subsequent oncologic risks. Current guidelines recommend open resections all cases suspected ACC independent size; however, there has been increased adoption MIS over time. We sought determine whether rise in is associated with worse survival outcomes ACC.The National Cancer Database was queried patients who underwent...
Fibrolamellar hepatocellular carcinoma (FLC) is a disease that occurs in children and young adults. The development of FLC associated with creation fusion oncoprotein DNAJB1-PKAc kinase, which activates multiple cancer-associated pathways. aim this study was to examine the role human genomic regions, called cancer-enhancing regions or aggressive liver cancer domains (CEGRs/ALCDs), FLC. Previous studies revealed CEGRs/ALCDs are located oncogenes genes, regularly silenced normal tissues. Using...
Glypican-3 (GPC3) is a surface-bound proteoglycan overexpressed in pediatric liver cancer and utilized clinically as an immunohistochemical tumor marker. Furin proprotein convertase that ubiquitously expressed shown to modify GPC3 post-translationally. In experimental models of epithelial-based cancers, furin inhibition decreased cell migration proliferation representing potential therapeutic target.
Hepatoblastoma is the most common malignant liver tumor of childhood, with transplant and extended resection used as surgical treatments for locally advanced tumors. Although each approach has well-described post-operative complications, quality-of-life outcomes have not been described following two interventions. Long-term pediatric survivors hepatoblastoma who underwent conventional or transplantation at a single institution from January 2000-December 2013 were recruited to complete...
The absence of a clinically relevant animal model addressing the typical immune characteristics hepatocellular cancer (HCC) has significantly impeded elucidation underlying mechanisms and development innovative immunotherapeutic strategies. To develop an ideal recapitulating human HCC, immunocompetent male C57BL/6J mice first receive carbon tetrachloride (CCl4) injection to induce liver fibrosis, then histologically-normal oncogenic hepatocytes from young SV40 T antigen (TAg)-transgenic...
e22015 Background: Trisomy 18 (T18) is the second most common aneuploidy caused by additional copies of chromosome 18. It occurs at a rate 1 in 2000-6000 live births, with current 1-year survival rates between 5-10% births. Meta-analysis tumor T18 patients revealed 67 tumors, 44 (66%) being HB. The contribution underlying genetic alterations to tumorigenesis incompletely understood. There reversed gender ratio children and HB as well more favorable histology response treatment. These suggest...