A5008051323- Spondyloarthritis Studies and Treatments
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- CAR-T cell therapy research
- Liver Diseases and Immunity
- vaccines and immunoinformatics approaches
- IL-33, ST2, and ILC Pathways
- Systemic Sclerosis and Related Diseases
- Inflammatory mediators and NSAID effects
- Reproductive System and Pregnancy
- Otitis Media and Relapsing Polychondritis
- Dermatological and Skeletal Disorders
- Asthma and respiratory diseases
- Immune cells in cancer
- Vector-Borne Animal Diseases
- Inflammatory Bowel Disease
- Vector-borne infectious diseases
University of Oxford
2013-2016
Nuffield Orthopaedic Centre
2013-2016
John Radcliffe Hospital
2013-2014
University of Cagliari
2013
MRC Human Immunology Unit
2013
Polish Academy of Sciences
2011
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2011
The human leukocyte Ag HLA-B27 (B27) is strongly associated with the spondyloarthritides. B27 can be expressed at cell surface of APC as both classical β2-microglobulin-associated and free H chain forms (FHC), including disulfide-bonded homodimers (termed B27(2)). FHC forms, but not B27, bind to KIR3DL2. HLA-A3, which spondyloarthritis (SpA), also a ligand for In this study, we show that B27(2) more KIR3DL2 than other HLA-class I, HLA-A3. tetramers bound KIR3DL2-transfected cells KIR3DL2Fc...
Hard ticks subvert the immune responses of their vertebrate hosts in order to feed for much longer periods than other blood-feeding ectoparasites; this may be one reason why they transmit perhaps greatest diversity pathogens any arthropod vector. Tick-induced immunomodulation is mediated by salivary components, some which neutralise elements innate immunity or inhibit development adaptive immunity. As dendritic cells (DC) trigger and help regulate immunity, are an ideal target...
Objectives. HLA-B*27:05 is associated with AS whereas HLA-B*27:09 not associated. We hypothesized that different interactions KIR immune receptors could contribute to the difference in disease association between and HLAB*27:09. Thus, objective of this study was compare formation β2m-free heavy chain (FHC) including B27 dimers (B272) by their binding immunoreceptors.
There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show immunological responses induced by members a broad class inorganic crystalline materials are controlled purely their physicochemical properties highly predictable manner. We structurally and chemically homogeneous layered double hydroxides (LDHs) can elicit diverse human dendritic cell vitro. Using systems vaccinology approach, find every...
Human leukocyte antigen (HLA)-B27 (B27) is the strongest genetic factor associated with development of Ankylosing Spondylitis and other spondyloarthropathies (SpA), yet role it plays in disease pathogenesis remains unclear. We investigated expression potentially pathogenic non-conventional heavy chain forms (NC) B27 synovial intestinal tissues obtained from SpA patients. also determined presence NC-B27 joints, lymphoid gastrointestinal tissue transgenic (TG1) rats M.tuberculosis-induced SpA....
Cellular expression of non-classical forms human leukocyte antigen (HLA)-B27 (NC-B27) may be involved in spondyloarthritis (SpA) pathogenesis. We used a novel B27-specific monoclonal antibody, HD6, to ask if B27 transgenic (TG) rat splenocytes express these NC-B27 molecules. also investigated whether B27-binding peptides could affect the and functional immune recognition HD6-reactive molecules.Splenocytes from B27-TG, B7-TG non-transgenic rats, HLA-B27+ cell lines were stained with...
Data is presented showing expression of non-conventional (NC) heavy chain forms B27 in synovial tissues from SpA patients. the patterns NC-B27 joint, gastrointestinal and lymphoid transgenic (TG1) rats with M. tuberculosis-induced SpA. Expression was determined by immunohistochemistry flow cytometry using HC10 HD6 antibodies. These data are extension discussed "Non-conventional HLA-B27 expressed Spondyloarthritis joints gut tissue" (O. Rysnik, K. McHugh, L. van Duivenvoorde, N. Tok, G....
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and leading cause death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation atherogenesis. A number anti-TNF therapies are in current use for the treatment RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular risk ameliorated vascular function RA...