A5077703376- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Hormonal Regulation and Hypertension
- Retinal and Macular Surgery
- Acute Ischemic Stroke Management
- Drug-Induced Ocular Toxicity
- Neuroinflammation and Neurodegeneration Mechanisms
- melanin and skin pigmentation
- Mast cells and histamine
- Biomedical Research and Pathophysiology
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Acne and Rosacea Treatments and Effects
- Sarcoidosis and Beryllium Toxicity Research
- Saffron Plant Research Studies
- Drug-Induced Adverse Reactions
- Ophthalmology and Visual Health Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
University of California, Los Angeles
2022-2025
Hôpital Lariboisière
2016-2025
Université Paris Cité
2015-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Carl Zeiss (Germany)
2024
Bayer (United States)
2024
Novartis (Switzerland)
2024
Advisory Board Company (United States)
2024
Topcon (Netherlands)
2024
Allergan (France)
2024
Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no validated treatment and unknown pathogeny. In CSCR, dilation leakage of choroid vessels underneath the retina cause subretinal fluid accumulation retinal detachment. Because glucocorticoids induce aggravate CSCR are known to bind mineralocorticoid receptor (MR), may be related inappropriate MR activation. Our aim was assess effect activation on rat choroidal vasculature translate results patients....
Purpose: To determine the pathoanatomical alteration of ectopic inner foveal layers (EIFL) and its relationship to visual recovery after epiretinal membrane (ERM) peeling surgery. Methods: Clinical charts tracked spectral-domain optical coherence tomography images patients diagnosed with stage 3 4 ERM were reviewed analyzed preoperatively at 6 months postoperatively. Central macular thickness (CMT) EIFL measured these time points. Wilcoxon signed-rank test was used for analysis P < 0.05...
Based on experimental data showing that central serous chorioretinopathy could result from overactivation of mineralocorticoid receptor pathway in choroid vessels, the authors studied eplerenone, a antagonist, as potential treatment for chronic chorioretinopathy.This nonrandomized pilot study included 13 patients with at least 4-month duration, treated 25 mg/day oral eplerenone week followed by 50 1 or 3 months. The primary outcome measure was changes macular thickness recorded optical...
To assess the rate of choroidal neovascularization (CNV) detected by optical coherence tomography angiography (OCTA) in flat irregular pigment epithelium detachment (PED) chronic central serous chorioretinopathy.Data on all consecutive patients with chorioretinopathy who underwent OCTA over a 1-year period were reviewed. The presence PED, which was defined as an elevation retinal allowing visualization distinct Bruch's membrane assessed high-resolution OCT B-scan. Clinical, multimodal...
To evaluate the effect of spironolactone, a mineralocorticoid receptor antagonist, for nonresolving central serous chorioretinopathy.This is prospective, randomized, double-blinded, placebo-controlled crossover study. Sixteen eyes 16 patients with chorioretinopathy and persistent subretinal fluid (SRF) at least 3 months were enrolled. Patients randomized to receive either spironolactone 50 mg or placebo once day 30 days, followed by washout period 1 week then crossed over another days. The...
In Brief Purpose: Thick choroid (pachychoroid) is associated with central serous chorioretinopathy (CSC), but whether pachychoroid inherited unknown. Methods: a prospective observational study, first- or second-degree relatives (16 individuals) of 5 patients CSC had refraction and visual acuity measurement, fundus examination, nonmydriatic photography, autofluorescence photography. Eyes were graded using the following criteria: 0: normal 1: focal retinal pigment epithelium hyperfluorescence...
To study the relationship between location of cystoid spaces and retinal capillary nonperfusion areas in diabetic macular edema (DCME).In this retrospective study, 24 eyes 21 patients with chronic DCME were followed using optical coherence tomography angiography. The density superficial plexus deep was measured AngioAnalytics software all 20 healthy controls. Diabetic improved spontaneously or after treatment 11 eyes.The intraretinal surrounded by capillary-flow void 71% cases 96% cases. had...
Fouad, Yousef A. MD; Santina, Ahmad Bousquet, Elodie MD, PhD; Sadda, Srinivas R. Sarraf, David MD Author Information
Glucocorticoids are used to treat macular edema, although the mechanisms underlying this effect remain largely unknown. The authors have evaluated in normal and endotoxin-induced uveitis (EIU) rats, effects of dexamethasone (dex) triamcinolone acetonide (TA) on potassium channel Kir4.1 aquaporin-4 (AQP4), two main retinal Müller glial (RMG) channels controlling fluid movement.Clinical as well relatively low doses dex TA were injected vitreous rats evaluate their influence AQP4 expression 24...
Abstract Objective HCQ is an essential medication in SLE, proven to lengthen survival and reduce flares. Its use, however, limited by its rare but severe ophthalmological complications. Here, we aimed analyse factors associated with retinopathy including blood levels. Methods This case–control study compared SLE patients without retinopathy, defined abnormal results for at least two of the following tests: automated visual fields, spectral-domain optical coherence tomography (SD-OCT),...
Purpose To identify the factors predicting visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR) through 12 months. Methods Patients diagnosis of CSCR, either acute or chronic, were included this multicentric, retrospective study. Demographic factors; systemic risk macular thickness (CMT), subfoveal choroidal (SFCT), linear extent ellipsoid zone (EZ) interdigitation damage on optical coherence tomography; details leak fluorescein angiography indocyanine green as...
Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing dexamethasone dispersions (DX-PUD) as system in rat model endotoxin-induced uveitis (EIU).In vitro was studied using PUD 8%, 20%, and 30% (wt/wt) DX. Cytotoxicity degradation products DX-PUD assessed on human ARPE-19 cells...
We have previously shown that the eye is a mineralocorticoid-sensitive organ and we now question role of mineralocorticoid receptor (MR) in ocular inflammation. The endotoxin-induced uveitis (EIU), rat model human intraocular inflammation, was induced by systemic administration lipopolysaccharide (LPS). Evaluations were made 6 24 hours after injection aldosterone (simultaneous to LPS injection). Three onset EIU, MR glucocorticoid metabolizing enzyme 11-beta hydroxysteroid dehydrogenase type...