A5082053266- Bone Tissue Engineering Materials
- Magnesium Alloys: Properties and Applications
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- High Entropy Alloys Studies
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- Immunotherapy and Immune Responses
- Orthopaedic implants and arthroplasty
- Cancer-related gene regulation
- Alcohol Consumption and Health Effects
- Antibiotic Resistance in Bacteria
- Liver Disease Diagnosis and Treatment
- Additive Manufacturing Materials and Processes
- interferon and immune responses
- Traditional Chinese Medicine Studies
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Heat shock proteins research
Yueyang Hospital
2023-2024
Shanghai University of Traditional Chinese Medicine
2023-2024
University of Science and Technology of China
2022-2024
Guangxi Medical University
2024
Shandong University
2024
Chengdu Third People's Hospital
2024
Southwest Jiaotong University
2024
Xuzhou Medical College
2023
Xuzhou Central Hospital
2020-2023
China Medical University
2010-2023
Laser powder bed fusion (L-PBF) of magnesium (Mg) alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects. However, one key technical difficulties lies in poor L-PBF process performance Mg, contributed by high susceptibility oxidation, vaporization, thermal expansion, attachment etc. This work investigated influence energy input scanning strategy on formation quality using WE43 powder,...
The effects of pore size in additively manufactured biodegradable porous magnesium on the mechanical properties and biodegradation scaffolds as well new bone formation have rarely been reported. In this work, we found that high temperature oxidation improves corrosion resistance scaffold. And characteristics scaffolds, formation, were investigated using with three different sizes, namely, 500, 800, 1400 μm (P500, P800, P1400). We discovered P500 group much better than those other two groups....
Laser powder bed fusion (L-PBF) has been employed to additively manufacture WE43 magnesium (Mg) alloy biodegradable implants, but L-PBF samples exhibit excessively rapid corrosion. In this work, dense were built with the relativity density reaching 99.9%. High temperature oxidation was performed on in circulating air via various heating temperatures and holding durations. The diffusion at elevated generated a gradient structure composed of an oxide layer surface, transition middle matrix....
Laser powder bed fusion (L-PBF) of Mg alloys has provided tremendous opportunities for customized production aeronautical and medical parts. Layer thickness (LT) is great significance to the L-PBF process but not been studied alloys. In this study, WE43 alloy bulk cubes, porous scaffolds, thin walls with layer thicknesses 10, 20, 30, 40 μm were fabricated. The required laser energy input increased increasing was different cubes scaffolds. Porosity tended occur at connection joints in...
Tumor microenvironment and chemokines play a significant role in cancer chemoresistance. This study was designed to reveal the important of CXCL2 platinum resistance epithelial ovarian (EOC). Differently expressed (DE) genes were screen out based on analysis GSE114206 dataset GEO database. The expression DE further validated platinum- resistant sensitive EOC. Cell viability assay cell apoptosis performed explore roles stemness characteristics signaling pathway regulated by also investigated...
Heat shock factor 1 (HSF1) has watershed significance in different tumors. However, the roles and driving forces for HSF1 colorectal cancer (CRC) are poorly understood. Our study integrally analyzed CRC by bioinformatics experiments. The expression prognostic characteristics of were via UALCAN, GEPIA2, TISIDB, Prognoscan HPA databases. Then, we correlation between immune features TIMER2 database. Subsequently, explored abnormal results showed that was overexpressed correlated with poor...
Perioperative neurocognitive disorders (PNDs) are a type of cognitive dysfunction occurring with higher incidence in elderly patients. However, the pathological mechanism PND and effective treatment remain elusive. We generated mouse model by providing wild-type mice surgical trauma; our case, we used tibial fracture to investigate pathology. Mice aged 7-8 months were randomly divided into two groups: surgery (tibial fracture) group control (sham) group. All subjected anesthesia. examined...
Primary vaginal melanoma is rare compared to cutaneous melanoma, and it has a high rate of invasion metastasis. The prognosis tumors poor the quality life patients low. In addition traditional surgical non-surgical treatment, combined treatments are more effective for with distant metastatic melanoma. Due immunogenicity malignant immunotherapy become an treatment strategy application immune checkpoint inhibitors (ICIs), outstanding achievements have been made in disease. Studies shown that...
Chronic alcoholic liver disease (CALD) is a global health problem which includes multiple pathological processes such as immune inflammation and oxidative stress. 4-hydroxy-2(3H)-benzoxazolone (HBOA), an alkaloid isolated from
Abstract Compatibility, morphology structure, and mechanical properties of CPVC/ABS (Chlorinated polyvinyl chloride/acrylonitrile‐butadiene‐styrene) blends were studied. The core‐shell ratios ABS set at 40/60 70/30. interface interactions between CPVC changed by modifying the acrylonitrile (AN) content shell. compatibility with shell was studied CPVC/SAN different AN in SAN. Dynamic analysis results accordance morphological CPVC/ABS. which polybutadiene to 15 wt % Results showed, change...
Emerging studies support the oncogenic role of WD repeat domain 62 (WDR62) in few tumors, while no pan-cancer analysis is available. In this study, we analyzed systematically WDR62 across a series human tumors based on bioinformatic data mining. The expression level was via GEPIA2, TIMER, UALCAN, and StarBase databases. prognostic StarBase, TISIDB, TCGA portal, Kaplan-Meier Plotter, PrognoScan Then, explored causes for abnormal portal UALCAN Subsequently, STRING GeneMANIA databases were used...
Cervical squamous cell carcinoma (CESC) is the gynecologic malignancy with high incidence rate and mortality rate. Oxidative stress participates in gene regulation malignant tumor progression, including CESC.RNA-seq, clinical information, genomic mutation were from The Cancer Genome Atlas- (TCGA-) CESC GSE44001 datasets. stress-related genes obtained set enrichment analysis (GSEA) website. ConsensusClusterPlus was used for clustering, which assessed by Kaplan-Meier (KM) survival curve...
Only a few studies have examined how pore geometry affects the mechanical characteristics, biological behavior, and degradation of additively manufactured biodegradable porous magnesium. In this work, effects on qualities, degradation, behavior were investigated using three typical architectures with same porosity. The structures found to satisfy bone tissue engineering requirements because they had sufficient resistance tunable compressive characteristics. All types magnesium alloy...
Coronary artery disease (CAD) is a leading cause of death, and microRNAs (miRNAs) are widely involved in physiological pathological processes CAD. We chose the targetscore method calculated via variational Bayesian Gaussian mixture model (VB‑GMM) as prediction target genes. By observing density overlap, we selected thresholds miRNA‑1 miRNA‑155. In total, 18 genes miRNA‑1, 19 miRNA‑155 were identified. The threshold miRNA‑146a was using |logFC| value, 16 screened out. this study, our major...
This study evaluated the radiosensitising effect of niraparib; a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism. Twenty-four 3-5-week-old female BALB/c mice, inoculated with into right hind leg, were randomly assigned eight groups three per group treated. The tumour volume was significantly reduced under niraparib + radiotherapy combination as compared to monotherapy untreated mice. growth delayed...
Multidrug-resistant (MDR) Enterobacteriales infections have become an urgent global threat to public health. The aim of this study was evaluate the efficacy zidovudine-amikacin combination therapy in vitro and vivo. Molecular characteristics antibiotic resistance profiles 53 amikacin-resistant MDR, extensively drug-resistant (XDR), or pan-drug-resistant (PDR) clinical isolates were examined via PCR susceptibility testing. Checkerboard assays performed for these assess synergistic effects...
Introduction: Systematic pan-cancer analysis of the roles and regulatory mechanisms for PRR7-AS1 is currently not available. Methods: In present study, a comprehensive bioinformatic approach was used to mine underlying oncogenic effects PRR7-AS1, including expression status, prognostic value immune characteristics. Results: We discovered that remarkably upregulated in most cancer types exhibited negative correlation with prognosis. Furthermore, inversely connected majority tumor-infiltrating...