Rozenn Esvan
A5040787921- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pneumonia and Respiratory Infections
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral gastroenteritis research and epidemiology
- Heart Failure Treatment and Management
- HIV Research and Treatment
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- HIV-related health complications and treatments
- Hepatitis Viruses Studies and Epidemiology
- Antiplatelet Therapy and Cardiovascular Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Metabolomics and Mass Spectrometry Studies
- Parvovirus B19 Infection Studies
- Diverse Scientific Research Studies
- Parasites and Host Interactions
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Rabies epidemiology and control
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2022-2024
University of Rome Tor Vergata
2024
Sapienza University of Rome
2013-2021
Dipartimento della Protezione Civile
2018
Policlinico Umberto I
2015-2018
Adults hospitalized for community-acquired pneumonia (CAP) have an increased risk of myocardial infarction. Corticosteroid treatment lowers CAP morbidity and mortality, but it is not known whether influences in-hospital infarction.The aim the present study was to investigate potential interplay between corticosteroid infarction in adults with CAP.We retrospectively analyzed referred University Hospital Policlinico Umberto I (Rome, Italy), consecutively recruited, prospectively followed until...
Transmitted drug resistance (TDR) is still a critical aspect for the management of individuals living with HIV-1. Thus, its evaluation crucial to optimize HIV care.
Here we describe a case of methicillin-resistant coagulase-negative staphylococci prosthetic valve endocarditis in patient considered not eligible for replacement due to high perioperative mortality risk and who did tolerate oral antibiotic treatment. Under these circumstances, intravenous long-term chronic suppressive therapy with dalbavancin, scheduling the doses using serum bactericidal activity titers, proved be safe effective.
It has been shown that sexual hormones have an opposite effect on hepatic fibrosis progression and hepatocellular carcinoma development. Sex differences among 2,762 chronic HBsAg carriers consecutively referring Italian hospitals in 2001 2007 evaluated, particularly focusing the role of gender severity liver disease. The overall sex ratio (males/females) was 2.6. Females were more likely born abroad new diagnosis cases; but less HIV coinfected. No difference observed regarding coinfection...
Human and viral microRNAs (miRNAs) are involved in the regulation of gene transcription, establishment their profiles acute (AHI) chronic (CHI) HIV infections may shed light on pathogenetic events related to different phases disease. Next-generation sequencing (NGS) miRNA libraries was performed, reads were used analyze differential expression plasma with AHI CHI. Functional analysis then undertaken investigate biological processes characterizing two infection. Except for hsa-miR-122-5p,...
Torquetenovirus (TTV) is the most abundant component of human blood virome and its replication controlled by a functioning immune system. In this study, TTV was evaluated in 21 people with acute HIV infection (AHI) reconstitution following antiretroviral therapy (ART). PBMC-associated HIV-1 DNA, as well plasma RNA, were measured real-time PCR. CD4 CD8 differentiation, activation, exhaustion, senescence phenotypes analyzed flow cytometry. Thirteen healthy donors (HD) twenty-eight chronically...
Direct-acting antivirals (DAAs) treatment, although highly efficacious for the treatment of hepatitis C virus (HCV) infection, may not completely reconstitute HCV-mediated dysregulated immune system, especially in patients co-infected with human immunodeficiency (HIV) and HCV.We aimed to evaluate impact HCV eradication following DAA therapy on system liver disease improvement through comparative monitoring 10 mono-infected HCV/HIV under combined antiretroviral (cART). Early late longitudinal...
Abstract Background/Aims Hepatitis C virus (HCV) has been identified in tubular epithelial cells of infected patients; however, the presence dysfunction, which is a risk factor for chronic kidney disease (CKD), never examined vivo. The present prospective longitudinal study aimed to estimate prevalence dysfunction alone or with glomerular damage and its evolution after HCV clearance cirrhotic patients. Methods One hundred thirty‐five consecutive Child‐Pugh A patients were evaluated before...
Hepatitis C virus (HCV) infection induces a long-term inflammatory response and oxidative-stress in the liver microenvironment, leading to hepatic fibrosis metabolic alterations. Direct-acting-antiviral-agents (DAAs) induce HCV-clearance, even though damage is only partially restored. In this context, understanding impact of viral-eradication on activities could allow optimizing care patient. The present prospective longitudinal study aims at characterizing urinary profile HCV-induced severe...
The recent resurgence of Mpox in central Africa has been declared again a Public Health Emergency International Concern (PHEIC) requiring coordinated international responses. Vaccination is priority to expand protection and enhance control strategies, but the vaccine's need exceeds currently available doses. Intradermal administration one-fifth standard Modified-Vaccinia-Ankara (MVA-BN) dose was temporarily authorized during 2022 PHEIC. Studies conducted before provided evidence about...
The aim was to investigate whether switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/F/TDF) bictegravir/emtricitabine/tenofovir alafenamide (BIC/F/TAF) may improve neuropsychiatric symptoms and neurocognition. Pilot, single-arm, prospective study of persons with HIV (PWH) on the efficacy safety EFV/F/TDF BIC/F/TAF. Participants underwent neuropsychological assessment (NPA) at switch (T0) after 48 weeks (T1). NPA carried out through a standardized battery 12 tests....
The recent resurgence of Mpox in central Africa has been declared again a Public Health Emergency International Concern (PHEIC) requiring coordinated international responses. Vaccination is priority to expand protection and enhance control strategies, but the vaccine's need exceeds currently available doses. Intradermal (ID) administration one-fifth standard Modified-Vaccinia-Ankara (MVA-BN) dose was temporarily authorized during 2022 PHEIC. Studies conducted before provided...
Background: With advances in antiretroviral therapy for HIV treatment, newer drug combinations provide improved efficacy, safety, and compliance. This study evaluates switching to a regimen of doravirine (DOR), tenofovir disoproxil fumarate (TDF), lamivudine (3TC) cohort people living with (PLWH). Methods: this Italian retrospective included 426 PLWH who switched from rilpivirine (RPV)/TDF/emtricitabine (FTC) DOR/3TC/TDF. The analysis focused on treatment effectiveness, metabolic renal...
Background: The recent resurgence of mpox in central Africa has been declared a new public health emergency international concern (PHEIC) requiring coordinated responses. Vaccination is priority to expand protection and enhance control strategies, but the vaccine’s need exceeds currently available doses. Intradermal (ID) administration one-fifth standard modified vaccinia Ankara (MVA-BN) dose was temporarily authorized during 2022 PHEIC. Studies conducted before provided evidence about...