A5100728696- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Periodontal Regeneration and Treatments
- Head and Neck Surgical Oncology
- Peptidase Inhibition and Analysis
- Oral and Maxillofacial Pathology
- Tracheal and airway disorders
- Attention Deficit Hyperactivity Disorder
- Immune Cell Function and Interaction
- Sinusitis and nasal conditions
- Protein Degradation and Inhibitors
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Bioinformatics and Genomic Networks
- Suicide and Self-Harm Studies
- Infectious Diseases and Tuberculosis
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Otolaryngology and Infectious Diseases
- Dental Implant Techniques and Outcomes
- Lung Cancer Research Studies
Bengbu Medical College
2024
Shenyang Pharmaceutical University
2023-2024
First Affiliated Hospital Zhejiang University
2020-2024
Harvard University
2019-2024
Massachusetts General Hospital
2018-2024
Beijing Chaoyang Emergency Medical Center
2024
Capital Medical University
2023-2024
Zhejiang University
2022-2024
Center for Cancer Research
2018-2024
Peking University
2012-2023
Chronic inflammation's tumor-promoting potential is well-recognized; however, the mechanism underlying development of this immune environment unknown. Studying transition from acute, tumor-suppressive to chronic, allergic contact dermatitis (ACD) revealed how chronic inflammation develops. Epidermis-derived interleukin (IL)-33 up-regulation and its induction regulatory T cell (Treg) accumulation in skin preceded acute ACD triggered ACD. Mice lacking IL-33 were protected cancer sequela...
It is essential to characterize underlying molecular mechanism associated with head and neck squamous cell carcinoma (HNSCC) identify promising therapeutic targets. Herein, we explored role of homeobox transcript antisense RNA (HOTAIR) in HNSCC regulate stanniocalcin-2 (STC2) by sponging microRNA-206 (miR-206).HNSCC-related differentially expressed genes regulation network amongst HOTAIR, miR-206 STC2 were identified. Next, effect HOTAIR on biological functions was identified after...
Cancer-prone breast gland exposure to a carcinogen induces immune factors in cancer cells and immunity against metastasis.
We aimed to investigate whether the tumor-to-blood SUV ratio (SUR) and metabolic parameters of F-FDG uptake could predict occult lymph node metastasis (OLM) in clinically node-negative (cN0) lung adenocarcinoma. retrospectively reviewed 157 patients with cN0 adenocarcinoma who underwent both preoperative PET/CT surgical resection systematic dissection. The SUVmax, SUVmean, MTV, total lesion glycolysis (TLG) primary tumor was measured on workstation. SURmax, SURmean, TLGsur were derived from...
This study aimed to develop a preoperative positron emission tomography (PET)-based radiomics model for predicting occult lymph node metastasis (OLM) in clinical N0 (cN0) solid lung adenocarcinoma.The fluorine-18-fludeoxyglucose (18F-FDG) PET images of 370 patients with cN0 adenocarcinoma confirmed by histopathological examination were retrospectively reviewed. Patients divided into training and validation sets. Radiomics features relevant data extracted from images. A nomogram was developed...
To investigate the feasibility of an endoscopic-assisted postauricular-groove approach parotidectomy and to evaluate advantages limitations such approach.A total 72 patients with parotid gland tumors underwent a procedure between January 2014 2016. Of aforementioned patients, 15 were treated by (group I), whereas remaining 57 Blair "S" incision II).Difference in visual analogue scale score for aesthetic outcome (0 vs 3) median intraoperative blood loss (30 50 mL) was statistically...
Objective Lymph node metastasis is the most important factor influencing prognosis of oral squamous cell carcinoma (OSCC) patients. However, there no proper method for predicting lymph metastasis. This study aimed to construct and validate a preoperative prediction model guide personalized neck management based on gene expression profile clinicopathological parameters OSCC. Methods Based previous related genes in OSCC, mRNA candidate was evaluated by real-time PCR OSCC specimens. In this...
Carcinogen exposure is strongly associated with enhanced cancer immunogenicity. Increased tumor mutational burden and resulting neoantigen generation have been proposed to link carcinogen However, the neoantigen-independent immunological impact of on unknown. Here, we demonstrate that chemical carcinogen-exposed cells fail establish an immunosuppressive microenvironment (TME), in their T cell-mediated rejection vivo. A carcinogen-treated breast cell clone lacked any additional coding region...
Abstract Objective Non-suicidal self-injurious (NSSI) behaviors pose a significant threat to the physical and psychological well-being of adolescents. This study investigated addictive nature NSSI their association with impulsivity decision-making, aiming provide evidence-based insights for development multiple effective treatment interventions adolescents depressive disorders exhibiting characteristics in behaviors. Methods A total 126 adolescent outpatients inpatients diagnosed disorder...
Non-suicidal self-injury (NSSI) behaviors pose a significant threat to the physical and psychological well-being of adolescents. Recent research suggests that persistent, uncontrollable repetitive NSSI can be conceptualized as behavioral addiction. The addictive feature behavior assessed using Ottawa inventory (OSI), higher addiction score indicates more serious behavior. This study aims explore relationship impulsivity decision-making on features in adolescents with depressive disorder,...
Previous literature has implicated the sustained expression of FOXM1 in numerous human cancers, including head and neck squamous cell carcinoma (HNSCC). The current study aimed to elucidate function regulatory mechanism HNSCC.Western blot RT-qPCR methods were performed evaluate Linc-ROR, FOXM1, LMO4 HNSCC tissue samples cells. binding between Linc-ROR was analyzed using a ChIP assay. Various cellular processes proliferation invasion abilities assessed following alteration Xenograft mouse...
Recent studies have reported the crucial role of stanniocalcin-2 (STC2) in hepatocellular carcinoma; however, its head and neck squamous cell carcinoma (HNSCC) remains elusive. In this study, microRNA-206 (miR-206) was predicted to target STC2 gene. The study herein aimed elucidate effect miR-206 on HNSCC by targeting STC2. highly expressed tissues cells. By STC2, decreased mRNA protein expression Importantly, our showed that blocked Akt signaling pathway inhibiting Intriguingly, data from...
This study aimed to identify whether NTR is the independent risk factor for progression-free survival (PFS) and overall (OS) in patients treated with concurrent chemo-radiotherapy (cCRT).We retrospectively studied 106 T1-4N1-3M0 non-small cell lung cancer cCRT. The maximum standardized uptake value (SUVTumor) of primary tumor metastatic lymph nodes (SUVLN) were measured. prognostic significance predicting PFS OS was assessed. A multi-adjusted spline regression model conducted provide more...