A5006416698- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Retinal Development and Disorders
- Ichthyology and Marine Biology
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Retinal Diseases and Treatments
- Olfactory and Sensory Function Studies
- Animal Behavior and Reproduction
- Hemispheric Asymmetry in Neuroscience
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Connexins and lens biology
- Retinoids in leukemia and cellular processes
- Morphological variations and asymmetry
- Marine animal studies overview
- Retinopathy of Prematurity Studies
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Circular RNAs in diseases
- Aquaculture disease management and microbiota
- Cancer-related Molecular Pathways
- interferon and immune responses
- Single-cell and spatial transcriptomics
- Biomedical Text Mining and Ontologies
Universidade de Santiago de Compostela
2016-2025
Centro de Investigaciones Biológicas Margarita Salas
2015
Laboratoire de Neurobiologie Cellulaire et Moléculaire
2001-2007
Institut de Chimie des Substances Naturelles
2007
Centre National de la Recherche Scientifique
2006
Abstract The sighted surface‐dwelling (surface fish, SF) and the blind cave‐living (cavefish, CF) forms of Astyanax mexicanus offer a unique opportunity to study evolutionary changes in developmental mechanisms that lead retinal degeneration. Previous data have shown role increased midline Sonic Hedgehog (Shh) signalling cavefish eye degeneration (Yamamoto et al. [ 2004 ] Nature 431:844–847). Here, we compared major steps development SF CF between 14 hours 5 days development. We analyzed...
Ocular health may strongly benefit from the supply of antioxidant agents that counteract free radicals and reactive oxygen species responsible for long-term eye diseases. Additionally, natural antioxidants like resveratrol can inhibit bacteria growth restore microbiota. However, their use is hindered by limited solubility, fast degradation, low ocular permeability. This work aimed to overcome these limitations preparing single mixed micelles Pluronic® F127 casein serve as nanocarriers....
Pax6 is a highly conserved transcription factor that appears involved in the entire process of retinogenesis, including maintenance proliferation retinal progenitors and differentiation particular neuron fates. To gain insight into retinogenesis fish, we study dynamics expression developing mature retina two sharks inhabit environments, compare it with marker cell (proliferating nuclear antigen, PCNA) markers neuronal differentiation, such as glutamic acid decarboxylase (GAD), calretinin...
The olfactory system represents an excellent model for studying different aspects of the development nervous ranging from neurogenesis to mechanisms axon growth and guidance. Important findings in this field come comparative studies. We have analyzed key events shark Scyliorhinus canicula by combining immunohistochemical tract-tracing methods. describe first time a cartilaginous fish early population pioneer HuC/D-immunoreactive (ir) neurons that seemed delaminate pit epithelium migrate...
Neural stem cells give rise to transient progenitors termed neuroepithelial (NECs) and radial glial (RGCs). RGCs represent the major source of neurons, glia adult in several regions central nervous system (CNS). are mostly mammals, but they widely maintained CNS fishes, where continue be morphologically similar mammalian brain fulfill roles as guide for migrating neurons. The retina fishes offers an exceptional model approach study neurogenesis because presence constitutive proliferation...
The basic anatomy of the elasmobranch brain has been previously established after studying organization different subdivisions in adult brain. However, despite relatively abundant immunohistochemical and hodologic studies performed species sharks skates, some remains unclear. present study focuses on regions which basis anatomical data adults remain controversial, such as subpallium, mainly striatal subdivision. Taking advantage great potential lesser spotted dogfish, <i>Scyliorhinus...
The cerebellum is recognized as an evolutionary innovation of jawed vertebrates, whose most primitive group represented by the chondrichthyans, or cartilaginous fishes. A comprehensive knowledge cerebellar connections in these fishes might shed light on basal organization system. Although precerebellar system known adults, developmental studies are essential for understanding origin and evolution nuclei. In present work we performed a study embryos juveniles advanced shark species,...
Cartilaginous fishes (chondrichthyans) represent an ancient radiation of vertebrates currently considered the sister group gnathostomes with a bony skeleton that gave rise to land vertebrates. This out-group position makes chondrichthyans essential in assessing ancestral organization brain jawed To gain knowledge about hindbrain evolution we have studied its development shark, lesser spotted dogfish Scyliorhinus canicula by analyzing expression some developmental genes and origin...
The hypothalamus has been a central topic in neuroanatomy because of its important physiological functions, but mature organization remains elusive. Deciphering embryonic and adult is crucial an evolutionary approach the vertebrate forebrain. Here we studied molecular neighboring telencephalic domains cartilaginous fish, catshark, Scyliorhinus canicula, focusing on ScFoxg1a, ScShh, ScNkx2.1, ScDlx2/5, ScOtp, ScTbr1 expression profiles identification α-acetylated-tubulin-immunoreactive (ir),...
Radial glial cells (RGCs) are the first cell populations of nature to appear during brain ontogeny. They act as primary progenitor (stem) well a scaffold for neuronal migration. The proliferative capacity these cells, both in development and adulthood, has been subject interest past decades. In contrast with mammals where RGCs restricted specific ventricular areas adult brain, predominant element fishes. However, developmental studies on cartilaginous fishes scant. We have studied expression...
Neurogenesis is the process by which progenitor cells generate new neurons. As development progresses neurogenesis becomes restricted to discrete neurogenic niches, where it persists during postnatal life. The retina of teleost fishes thought proliferate and produce throughout Whether this capacity may be an ancestral characteristic gnathostome vertebrates completely unknown. Cartilaginous occupy a key phylogenetic position infer states fixed prior radiation. Previous work from our group...
The identification of genes that regulate proliferation is great importance to developmental biology, regenerative medicine and cancer research. Using an in situ screen on a cortical structure the medaka fish brain, we identified simplet gene (smp), which homologous human FAM53B gene. smp was expressed actively proliferating cells CNS throughout embryogenesis. It belongs family vertebrate-specific with no characterized biochemical domains. We showed bound 14-3-3 chaperones, as well SKIIP...
The dorsal part of the developing telencephalon is one brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by appearance a new neurogenic niche embryonic subventricular zone (SVZ). Here, kind amplifying progenitors (basal progenitors) expressing Tbr2, undergo second round divisions, which believed have contributed expansion neocortex. Accordingly, existence pallial SVZ been classically...