A5023509134- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Botulinum Toxin and Related Neurological Disorders
- Systemic Lupus Erythematosus Research
- Inflammatory Bowel Disease
- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Eosinophilic Esophagitis
- Vasculitis and related conditions
- Neurological and metabolic disorders
- Peripheral Neuropathies and Disorders
- Olfactory and Sensory Function Studies
- IL-33, ST2, and ILC Pathways
- Cardiovascular Function and Risk Factors
- Multiple Sclerosis Research Studies
- Pain Management and Treatment
- Cardiac Imaging and Diagnostics
- Autoimmune and Inflammatory Disorders
University College London
2022-2025
Chung-Ang University
2024-2025
Imperial College Healthcare NHS Trust
2015-2025
National Hospital for Neurology and Neurosurgery
2022-2025
Hammersmith Hospital
2015-2023
University College London Hospitals NHS Foundation Trust
2022
Imperial College London
2018-2020
Boston Scientific (United States)
2017
Canadian Rheumatology Association
2016
University of Hong Kong
2008
The activation pattern of localized reentry (LR) in atrial tachycardia remains incompletely understood. We used the ultra-high density Rhythmia mapping system to study patterns LR.LR was suggested by small rotatory activations (carousels) containing full spectrum color-coded map. Twenty-three left-sided tachycardias were mapped 15 patients (age: 64±11 years). 16 253±9192 points displayed per map, collected over 26±14 minutes. A total 50 carousels identified (median 2; quartiles 1-3 map),...
Bipolar electrogram voltage during sinus rhythm (V
BackgroundThe ganglionated plexuses (GPs) of the intrinsic cardiac autonomic system may play a role in atrial fibrillation (AF).ObjectiveWe hypothesized that ablating ectopy-triggering GPs (ET-GPs) prevents AF.MethodsGANGLIA-AF (ClinicalTrials.gov identifier NCT02487654) was prospective, randomized, controlled, 3-center trial. ET-GPs were mapped using high frequency stimulation, delivered within refractory period and ablated until nonfunctional. If triggered AF became incessant,...
Abstract Background MicroRNAs (miRNAs), key regulators of gene expression, are promising biomarkers and therapeutic targets in inflammatory bowel disease (IBD) due to their roles immune response tissue integrity. This study explores miRNA IBD, focusing on Crohn's (CD) pathogenesis potential therapies. We analyzed epithelial cell-derived expression CD patients versus healthy controls investigated how these miRNAs modulate inflammation experimental IBD models. Methods Terminal ileum samples...
Abstract Background Classical infratentorial superficial siderosis (iSS) is considered a rare but potentially disabling neurological disorder. It results from slow chronic blood extravasation into the cerebrospinal fluid and deposition of iron degradation product hemosiderin within subpial layers central nervous system. Susceptibility-weighted (SW) magnetic resonance imaging (MRI) reference diagnostic modality. Few studies have described population prevalence cerebellar or siderosis, there...
Background: Idiopathic inflammatory demyelinating disorders (IIDD) affect the central nervous system. In classical multiple sclerosis (CMS), brain, optic nerves [optic neuritis (ON)] and spinal cord [acute transverse myelitis (ATM)] are affected. neuromyelitis optica (NMO), predominantly NMO‐IgG, an autoantibody targeting aquaporin‐4, is a marker for NMO. We studied frequency clinical relevance of NMO‐IgG seropositivity in IIDD patients. Methods: Neuromyelitis optica‐IgG was detected by...
Abstract Introduction The ganglionated plexuses (GPs) of the intrinsic cardiac autonomic system are implicated in arrhythmogenesis. GP localization by stimulation epicardial fat pads to produce atrioventricular dissociating (AVD) effects is well described. We determined anatomical distribution left atrial GPs that influence (AV) dissociation. Methods and Results High frequency was delivered through a Smart‐Touch catheter atrium patients undergoing fibrillation (AF) ablation. Three...
Epicardial ganglionated plexuses (GP) have an important role in the pathogenesis of atrial fibrillation (AF). The relationship between anatomical, histological and functional effects GP is not well known. We previously described atrioventricular (AV) dissociating (AVD-GP) locations. In this study, we hypothesised that ectopy triggering (ET-GP) are upstream triggers ectopy/AF different anatomical distribution to AVD-GP.We mapped characterised ET-GP understand their neural mechanism AF left...
Abstract Background A growing body of evidence suggests that epithelial cell-derived microRNAs are involved in the pathogenesis inflammatory bowel disease (IBD). This immunological impairment leads to altered colonic permeability and release cytokines, such as IL-33. In this prospective cohort study, we studied expression (miRNA) Crohn’s (CD) patients compared healthy controls. We also investigated their potential role regulating inflammation experimental IBD animal models. Methods...
His bundle pacing (HBP) is an alternative to biventricular (BVP) for delivering cardiac resynchronization therapy (CRT) in patients with heart failure and left branch block (LBBB). It not known whether ventricular activation times patterns achieved by HBP are equivalent intact conduction systems all LBBB resynchronized HBP.
Background: The mechanisms underlying atrial fibrillation (AF) remain controversial. We developed Representation of Electrical Tracking or Origin-Mapping to characterize activation wavefronts by direction and uniformity, accumulating data as an orbital plot analyzed frequency histograms. applied this technique patients undergoing AF ablation determine if is random. Methods: Patients persistent were recruited, AFocusII was positioned at multiple left locations kept steady for 1 minute collect...
Abstract Background Ablation of autonomic ectopy-triggering ganglionated plexuses (ET-GP) has been used to treat paroxysmal atrial fibrillation (AF). It is not known if ET-GP localisation reproducible between different stimulators or whether can be mapped and ablated in persistent AF. We tested the reproducibility left location using high-frequency high-output In addition, we feasibility identifying locations fibrillation. Methods Nine patients undergoing clinically-indicated AF ablation...
Established features of classical infratentorial superficial siderosis (iSS) include hearing loss, impaired balance, myelopathy and, less commonly, cognitive compromise. Olfactory function may be affected but dedicated studies are lacking. This study aimed to assess the prevalence olfactory dysfunction in iSS and correlate it with auditory functions.Ten participants completed University Pennsylvania Smell Identification Test (UPSIT). The scores were compared population norms; regression...
Optimal criteria for diagnosing and monitoring response to treatment infectious inflammatory medium-large vessel intracranial vasculitis presenting with stroke are lacking. We integrated wall MRI arterial spin labelling into our routine clinical pathway detect presumed vasculopathy, monitor disease activity, in patients syndromes. used predefined standardized radiological define enhancement, all imaging findings were rated blinded details. Between 2017 2018, or transient ischaemic attack...
Background: The relation between atrioventricular delay (AVD) and left ventricular (LV) pump function is considered to be parabolic shaped.Limited clinical data exist on the effect of heart rate position shape this curve accuracy AVD optimization.Objective: We investigated atrial pacing AVD-LV optimization.Methods: optimization was performed in 9 patients with complete AV-block, treated dual chamber (n¼3) or biventricular (n¼6) using noninvasive systolic blood pressure (SBP) measurements,...