A5100336768- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Tea Polyphenols and Effects
- MicroRNA in disease regulation
- Synthesis of Organic Compounds
- Essential Oils and Antimicrobial Activity
- Chemokine receptors and signaling
- Synthesis and Biological Activity
- Synthesis and biological activity
- Cancer Mechanisms and Therapy
- Bioactive Compounds and Antitumor Agents
- Biochemical Analysis and Sensing Techniques
- Genomics, phytochemicals, and oxidative stress
- Bioactive Natural Diterpenoids Research
Chinese University of Hong Kong, Shenzhen
2022-2023
Xinxiang Medical University
2021
Qingdao Center of Resource Chemistry and New Materials
2020
Xi’an University
2016
Oxidized LDL (oxLDL) has been implicated in the pathogenesis of atherosclerosis accompanying lipid-laden cell appearance, inflammatory responses, and vascular dysfunction. This study examined potentials polyphenol quercitrin to inhibit oxLDL induction scavenger receptor A (SR-A) CD36 involving activation peroxisome proliferator-activated gamma (PPARgamma). J774A1 murine macrophages were cultured with 10 microg/mL Cu(2+)-oxLDL for various times presence 1-10 micromol/L quercitrin. at given...
Lung cancer in humans is majorly represented by non-small cell lung cells, and there a constant search for an efficient therapeutic approach. This study aims to find the anti-proliferative apoptotic effects of matricin on H1299 cells via activation MAPK pathway. Non-small were subjected viability analysis with MTT assay anti-proliferation different concentrations matricin. Apoptosis was determined annexin V/propidium iodide (PI) flow cytometric analysis. Analysis oxidative stress markers,...
Daldinins are a novel type of naturally occurring tricyclic heterocycles isolated from Daldinia concentrica. In this study, four daldinin A derivatives with different alkyl side chains were synthesized using the same synthetic protocol. Bioactivity tests first indicated that showed significant protection for endothelial cells against damage caused by high glucose. The derivative compound three carbon atoms on exhibited best effect.
Abstract Background Radix Sophorae Flavescentis (Kushen) is the principal herb consisting of Compound Kushen Injection (CKI), which has been approved for clinical treatment tumors. Although CKI widely used, especially on non-small cell lung cancer (NSCLC), its underlying mechanisms regarding microRNA-target gene-pathway remain unclear. Methods A549 line was selected as NSCLC model and treated with different concentrations to obtain mRNA miRNA expression profiles. Then differentially...