A5088375595- MicroRNA in disease regulation
- Agriculture, Soil, Plant Science
- Cancer-related molecular mechanisms research
- GABA and Rice Research
- Computational Drug Discovery Methods
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Climate Change and Health Impacts
- Bioactive natural compounds
- RNA and protein synthesis mechanisms
- Air Quality and Health Impacts
- Natural product bioactivities and synthesis
- Global Health Care Issues
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Machine Learning in Materials Science
- Ginseng Biological Effects and Applications
- Hippo pathway signaling and YAP/TAZ
- Cancer, Lipids, and Metabolism
- Neonatal Respiratory Health Research
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Antimicrobial Peptides and Activities
- Infant Nutrition and Health
Chinese University of Hong Kong, Shenzhen
2019-2025
Chinese University of Hong Kong
2024
Shenzhen Maternity and Child Healthcare Hospital
2021
MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18-25 nucleotides) that negatively control expression target genes at the post-transcriptional level. Owing to biological significance miRNAs, miRTarBase was developed provide comprehensive information on experimentally validated miRNA-target interactions (MTIs). To date, database has accumulated >13,404 MTIs from 11,021 articles manual curations. In this update, a text-mining system incorporated enhance recognition...
Abstract MicroRNAs (miRNAs) are noncoding RNAs with 18–26 nucleotides; they pair target mRNAs to regulate gene expression and produce significant changes in various physiological pathological processes. In recent years, the interaction between miRNAs their genes has become one of mainstream directions for drug development. As a large-scale biological database that mainly provides miRNA–target interactions (MTIs) verified by experiments, miRTarBase undergone five revisions enhancements. The...
Abstract In recent years, drug repositioning has emerged as a promising alternative to the time-consuming, expensive and risky process of developing new drugs for diseases. However, current database faces several issues, including insufficient data volume, restricted types, algorithm inaccuracies resulting from neglect multidimensional or heterogeneous data, lack systematic organization literature associated with repositioning, limited analytical capabilities user-unfriendly webpage...
Abstract MicroRNAs (miRNAs) are small non-coding RNAs (18–26 nucleotides) that regulate gene expression by interacting with target mRNAs, affecting various physiological and pathological processes. miRTarBase, a database of experimentally validated miRNA–target interactions (MTIs), now features over 3 817 550 MTIs from 13 690 articles, significantly expanding its previous version. The updated includes miRNA therapeutic agents, revealing roles in drug resistance strategies. It also highlights...
Background: XueBiJing injection (XBJ) is renowned for its multi-target pharmacological effects, including immunomodulatory, antithrombotic, and antioxidant activities, offering potential therapeutic benefits patients with severe infections such as sepsis Coronavirus disease 2019 (COVID-19). Despite clinical effectiveness, the molecular targets mechanisms of XBJ remain unclear, warranting further investigation. Purpose: This study aimed to identify key bioactive compounds in elucidate their...
Triple-negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive progression and limited treatment options, making early diagnosis prognosis critical. MicroRNAs (miRNAs) are crucial post-transcriptional regulators that influence gene expression. In this study, we unveil novel miRNA-mRNA interactions introduce prognostic model based on miRNA-target interaction (MTI), integrating regulatory correlation inference the machine learning method effectively predict...
As an agri-food by-product, the rice bran of pigmented rice, encompassing varieties such as red, black, and purple has garnered increasing attention due to its richness in terms bioactive compounds. Being mainly composed pericarp, aleuron, seed coat, germ, brown outer layer kernel offers potential health benefits applications skincare. Human skin serves primary barrier against external threats, including pathogens, pollutants, ultraviolet (UV) radiation. Notably, UV radiation accelerates...
Bloodstream infections (BSIs) pose a significant diagnostic challenge, largely due to the limitations of traditional methods such as blood cultures. These often yield low positive rates, have lengthy processing times that delay treatment, and are limited in detecting only narrow range pathogens. Such delays inaccuracies can critically impede timely clinical interventions, potentially compromising patient outcomes. Next-generation sequencing (NGS) is powerful tool for rapid, precise pathogen...
DNA methylation is an important epigenetic regulator in gene expression and has several roles cancer disease progression. MethHC version 2.0 (MethHC 2.0) integrated web-based resource focusing on the aberrant methylomes of human diseases, specifically cancer. This paper presents updated implementation by incorporating additional transcriptomes from public repositories, including 33 cancers, over 50 118 microarray RNA sequencing data TCGA GEO, accumulating up to 3586 manually curated >7000...
Drug–target interactions (DTIs) are considered a crucial component of drug design and discovery. To date, many computational methods were developed for drug–target interactions, but they insufficiently informative accurately predicting DTIs due to the lack experimentally verified negative datasets, inaccurate molecular feature representation, ineffective DTI classifiers. Therefore, we address limitations randomly selecting data from unknown pairs by establishing two validated datasets...
Air pollution is known to have notable negative effects on human health. Recently, the effect of air blood pressure among elderly has attracted researchers' attention. However, existing evidence not consistent, given that positive, null, and outcomes are presented in literature. In this study, we investigated relationship between (BP) indices pollutants (PM2.5, PM10, quality index) a specific population through panel study address knowledge gap.We obtained repeated BP measurements from...
Breast milk (BM) is a primary biofluid that plays crucial role in infant development and the regulation of immune system. As class rich biomolecules BM, microRNAs (miRNAs) are regarded as active factors contributing to growth development. Surprisingly, these molecules exhibit resilience harsh conditions, providing an opportunity for infants absorb them. In addition, many studies have shown miRNAs breast milk, when absorbed into gastrointestinal system, can act functional regulators...
Abstract MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the 3′-untranslated regions of target mRNAs, influencing various biological processes at post-transcriptional level. Identifying miRNA transcription start sites (TSSs) and factors’ (TFs) regulatory roles is crucial for elucidating function transcriptional regulation. miRStart 2.0 integrates over 4500 high-throughput datasets across five data types, utilizing a multi-modal approach annotate 28...
Introduction: Cinnamomi ramulus (CR) is one of the most widely used traditional Chinese medicine (TCM) with anti-cancer effects. Analyzing transcriptomic responses different human cell lines to TCM treatment a promising approach understand unbiased mechanism TCM. Methods: This study treated ten cancer CR concentrations, followed by mRNA sequencing. Differential expression (DE) analysis and gene set enrichment (GSEA) were utilized analyze data. Finally, in silico screening results verified...
Cyclic AMP receptor proteins (CRPs) are important transcription regulators in many species. The prediction of CRP-binding sites was mainly based on position-weighted matrixes (PWMs). Traditional methods only considered known binding motifs, and their ability to discover inflexible patterns limited. Thus, a novel site model called CRPBSFinder developed this research, which combined the hidden Markov model, knowledge-based PWMs structure-based affinity matrixes. We trained using validated data...
Background: Air pollution is known to have notable effects on human health. The influence of air blood pressure has attracted much attention recently. However, the existing evidence not consistent, since positive, null, and negative outcomes are presented in literature. In this study, we addressed knowledge gap by investigating association between (BP) indices pollutants (P2.5, PM10, quality index) specific elderly population through a panel study. Methods: We obtained repeated BP...
Herbal medicine Sanqi (SQ), the dried root or stem of Panax notoginseng (PNS), has been reported to have anti-diabetic and anti-obesity effects is usually administered as a decoction for Chinese medicine. Alternative utilizing PNS pure compound treatment, we are motivated propose an unconventional scheme investigate functions mixture. However, studies providing detailed overview transcriptomics-based signaling network in response seldom available.To explore reasoning treating metabolic...
Ubiquitination, a post-translational modification, refers to the covalent attachment of ubiquitin molecules substrates. This modification plays critical role in diverse cellular processes such as protein degradation. The specificity ubiquitination for substrates is regulated by E3 ligases. Dysregulation has been associated with numerous diseases, including cancers. In our study, we first investigated expression patterns ligases across 12 cancer types. Our findings indicated that tend be...
MicroRNA-483 was identified as the critical mediator of various diseases, especially cancers. As hub miRNA, genes connected to miR-483 potentially serve novel biomarkers for disease progression. To explore key regulators mediated by miR-483, validated and predictive connections TFs-miR-483 miR-483-mRNAs were collected constructed an integrative TF-miR-483-mRNA regulatory network. We incorporated TCGA data developed 15 cancer-specific sub-networks further investigate role in Analysis across...