A5081405835- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Mass Spectrometry Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Chemical Reactions and Isotopes
- Nanoplatforms for cancer theranostics
- Lipid metabolism and biosynthesis
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Zebrafish Biomedical Research Applications
Instituto de Investigación Sanitaria de Santiago
2021-2022
Universitat de Barcelona
2018
Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown be fully effective. In order solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could a suitable solution increase drug's action on the target site as well decrease adverse effects. For these reason, Memantine was loaded in biodegradable PLGA nanoparticles, produced by double emulsion method and surface-coated with polyethylene glycol. MEM–PEG–PLGA (NPs) were aimed blood–brain barrier (BBB) upon...
Background: Circulating tumor cells (CTC) have relevance as prognostic markers in breast cancer. However, the functional properties of CTCs or their molecular characterization not been well-studied. Experimental models indicate that only a few can survive circulation and eventually metastasize. Thus, it is essential to identify these surviving capable forming such metastases. Methods: We isolated viable from 50 peripheral blood samples obtained 35 patients with advanced metastatic cancer...
Background: Cancer metastasis is a deathly process, and better understanding of the different steps needed. The shedding circulating tumor cells (CTCs) CTC-cluster from primary tumor, its survival in circulation, homing are key events cascade. In vitro models CTCs vivo represent an excellent opportunity to delve into behavior metastatic cells, gain on how secondary tumors appear. Methods: Using zebrafish embryo, combination with mouse assays, as model spatiotemporal development metastases,...
Background: Circulating tumor cells (CTC) have relevance as prognostic markers in breast cancer. However, the functional properties of CTCs or their molecular characterization not been well-studied. Experimental models indicate that only a few can survive circulation and eventually metastasize. Thus, it is essential to identify these surviving capable forming such metastases. Methods: We isolated viable from 50 peripheral blood samples obtained 35 patients with advanced metastatic cancer...
Circulating Tumor Cells (CTCs) are shed from primary tumors and travel through the blood, generating metastases. CTCs represents a useful tool to understand biology of metastasis in cancer disease. However, there is lack standardized protocols isolate culture them. In our previous work, we presented oil-in-water nanoemulsions (NEs) composed lipids fatty acids, which showed benefit supporting CTC cultures metastatic breast patients. Here, present Peptide-Functionalized Nanoemulsions...
The culture and expansion of circulating tumor cells (CTCs) for ex vivo assays plays an important role in precision medicine. However, it still represents a big challenge translational research. Generating knowledge about the characteristics CTCs can help to shed light metastasis process. Furthermore, might allow performing functional analyses testing different drugs, guide clinical therapies. In this work, we present new methodology based on use nanosystems support CTCs. We have formulated...