A5090195136- dental development and anomalies
- Developmental Biology and Gene Regulation
- Hair Growth and Disorders
- Genomics and Chromatin Dynamics
- Telomeres, Telomerase, and Senescence
- Skin and Cellular Biology Research
- Hedgehog Signaling Pathway Studies
- Aluminum toxicity and tolerance in plants and animals
- Wnt/β-catenin signaling in development and cancer
- Magnesium in Health and Disease
- Cancer-related Molecular Pathways
- Axon Guidance and Neuronal Signaling
- Neuropeptides and Animal Physiology
- Cell death mechanisms and regulation
- Connective tissue disorders research
- Selenium in Biological Systems
- PI3K/AKT/mTOR signaling in cancer
- Ion Channels and Receptors
- Primate Behavior and Ecology
- Calcium signaling and nucleotide metabolism
- Fibroblast Growth Factor Research
- melanin and skin pigmentation
- Invertebrate Immune Response Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Protein Kinase Regulation and GTPase Signaling
Centre National de la Recherche Scientifique
2000-2025
Université de Lille
2011-2025
Unité de Glycobiologie Structurale et Fonctionnelle
2022-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022-2024
Inserm
2011-2022
Laboratoire de Physiologie Cellulaire
2017-2021
Transgene (France)
2016
University of Helsinki
2006-2012
Université Joseph Fourier
2000-2004
Institut pour l'avancée des biosciences
2004
Ectodermal organogenesis is regulated by inductive and reciprocal signalling cascades that involve multiple signal molecules in several conserved families. Ectodysplasin-A (Eda), a tumour necrosis factor-like molecule, its receptor Edar are required for the development of number ectodermal organs vertebrates. In mice, lack Edaleads to failure primary hair placode formation missing or abnormally shaped teeth, whereas mice overexpressing Eda characterized enlarged placodes supernumerary teeth...
Abstract Cellular senescence is implicated in a great number of diseases including cancer. Although alterations mitochondrial metabolism were reported as drivers, the underlying mechanisms remain elusive. We report mechanism altering function and OXPHOS stress-induced senescent fibroblasts. demonstrate that TRPC3 protein, acting controller Ca 2+ load via negative regulation IP 3 receptor-mediated release, down regulated regardless type inducer. This remodelling promotes...
Uncovering the origin and nature of phenotypic variation within species is first step in understanding between species. Mouse models with altered activities crucial signal pathways have highlighted many important genes networks regulating morphogenesis complex structures, such as teeth. The detailed analyses these indicated that balanced actions a few cell behavior modulate shape number Currently, however, most mouse studied had gross alteration morphology, whereas more subtle modification...
Ductal growth of the mammary gland occurs in two distinct stages. The first round branching morphogenesis during embryogenesis, and second commences at onset puberty. Currently, relatively little is known about genetic networks that control initial phases ductal expansion, which, unlike pubertal development, proceeds independent hormonal input female mice. Here we identify NF-κB downstream TNF-like ligand ectodysplasin (Eda) as a unique regulator embryonic prepubertal morphogenesis. Loss...
Ectodysplasin (Eda), a member of the tumor necrosis factor (Tnf) family, regulates skin appendage morphogenesis via its receptor Edar and transcription NF-κB. In humans, inactivating mutations in Eda pathway components lead to hypohidrotic ectodermal dysplasia (HED), syndrome characterized by sparse hair, tooth abnormalities, defects several cutaneous glands. A corresponding phenotype is observed Eda-null mice, where failure initiation first wave hair follicle development hallmark HED...
Anti-silencing function 1 (ASF1) is an evolutionarily conserved histone H3-H4 chaperone involved in the assembly/disassembly of nucleosome and modification. Two paralogous genes, Asf1a Asf1b, exist mouse genome. ubiquitously expressed its loss causes embryonic lethality. Conversely, Asf1b expression more restricted has been less studied. To determine vivo we generated a Asf1b-deficient line (Asf1b(GT(ROSA-βgeo)437)) which lacZ reporter gene driven by promoter. Analysis β-galactosidase...
Hair vibrissa follicle morphogenesis involves several cell segregation phases, in the dermis as well epidermis. The expression of Notch-related genes, which are established mediators multiple events Drosophila development, was studied by situ hybridisation during embryonic mouse and first adult hair cycle. results show that two receptors, Notch1 -2, three ligands, Delta1, Serrate1, Fringe regulators, Lunatic, Manic, Radical, expressed different locations morphogenetic stages. First,...
In the chick, most feathers are restricted to specific areas of skin, feather tracts or pterylae, while other areas, such as apteria, remain bare. embryo, expansion and closure somatopleure leads juxtaposition ventral pteryla, midventral apterium amnion. The embryonic proximal somatopleural mesoderm is determined form a feather-forming dermis at 2 days incubation (E2), distal extra-embryonic open determination. We found progressive, lateral expression Noggin in area, downregulation Msx1,...
The pattern of feather buds in a tract is thought to result from the relative ratios between activator and inhibitor signals through lateral inhibition process.We analyse role Drm/Gremlin, BMPs antagonist expressed during formation, dermal precursor, dense dermis, interbud dermis posterior condensation.We have altered activity Drm embryonic chick skin using retroviral vectors expressing drm/ gremlin bmps.We show that expression endogenous drm under control feedback loop induced by BMP...
Heavy metals are released into the environment in increasing amounts from different natural and anthropogenic sources. Among them, cadmium contaminates aquatic habitats represents a threat to Amphibians. To assess risks of exposure environment, we studied survival rate early tadpoles Xenopus laevis under CdCl
Xenopus oocytes are encompassed by a layer of follicular cells that contribute to oocyte growth and meiosis in relation maturation. However, the effects interaction between surface on meiotic processes unclear. Here, we investigated cell function using signaling heterologous-expressing capabilities. We found deprotected from their surrounding expressing epidermal factor (EGF) receptor (EGFR) Grb7 adaptor undergo accelerated prophase I metaphase II progression upon stimulation EGF. This...
The high‐affinity tyrosine kinase receptor MET plays a pivotal role in several facets of cell regulation. Although its mitogenic effect is well documented, some aspects connection patterns between signaling pathways involved cycle progression remain to be deciphered. We have used tractable heterologous expression system, the Xenopus oocyte, detect connections distinct cascades G2/M progression. Our results reveal that Src acts as an adapter via SH2 domain recruit 3‐phosphoinositide‐dependent...