Rajani Sharma

ORCID: 0000-0001-6439-4537
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About
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Research Areas
  • Liver Disease Diagnosis and Treatment
  • Liver Diseases and Immunity
  • Liver Disease and Transplantation
  • Microscopic Colitis
  • Celiac Disease Research and Management
  • Organ Transplantation Techniques and Outcomes
  • Alcohol Consumption and Health Effects
  • Hepatitis C virus research
  • Diabetic Foot Ulcer Assessment and Management
  • Blood Coagulation and Thrombosis Mechanisms
  • Peripheral Artery Disease Management
  • Fungal Infections and Studies
  • Viral gastroenteritis research and epidemiology
  • Global Cancer Incidence and Screening
  • Inflammatory Bowel Disease
  • Pregnancy and Medication Impact
  • Pancreatitis Pathology and Treatment
  • Hepatitis B Virus Studies
  • Antifungal resistance and susceptibility
  • Protease and Inhibitor Mechanisms
  • Peptidase Inhibition and Analysis
  • Viral-associated cancers and disorders
  • COVID-19 Clinical Research Studies
  • Cardiac tumors and thrombi
  • CNS Lymphoma Diagnosis and Treatment

Columbia University
2018-2025

Columbia University Irving Medical Center
2017-2024

Columbia College
2024

Royal College of Physicians
2024

Center for Digestive and Liver Diseases
2022

Sharma & Associates (United States)
2018

Sardar Patel Medical College
2014-2016

Sri Jayadeva Institute of Cardiovascular Sciences and Research
2015

Gandhi Medical College & Hospital
2015

Swami Rama Himalayan University
2015

Background and Aims Recent studies link NAFLD to an increased incidence of HCC extrahepatic cancers. However, earlier were small or lacked liver histology, which remains the gold standard for staging severity. Approach Results We conducted a population‐based cohort study all adults with histologically defined in Sweden from 1966 2016 (N = 8,892). was prospectively recorded histopathology submitted 28 Swedish pathology departments categorized as simple steatosis, nonfibrotic NASH,...

10.1002/hep.31845 article EN cc-by-nc-nd Hepatology 2021-04-03

Celiac disease (CeD) has been associated with a low response to hepatitis B (HBV) vaccination, but guidelines for testing and revaccination among individuals CeD are sparse. We examined the risk of future HBV in population-based Swedish cohort. Furthermore, we rate prior infection patients. All Sweden diagnosed biopsy-verified between 1990 2017 were identified through ESPRESSO Each individual was matched by age, sex, calendar year, birth country (Nordic vs. other) up 5 reference individuals....

10.1007/s10620-025-08878-3 article EN cc-by-nc Digestive Diseases and Sciences 2025-02-21

Persons with alcohol-related liver disease (ALD) are at an increased risk of death and liver-related endpoints, but the association incident cancer is not well understood, whether it differs across histopathological subgroups undefined.We investigated in 3,410 persons a diagnosis ALD available biopsy Sweden between 1969-2016, compared to matched reference population. Administrative coding from national registers data were used define exposure outcome status. Competing regression, adjusted...

10.1016/j.cgh.2021.01.005 article EN cc-by Clinical Gastroenterology and Hepatology 2021-01-09

Some, but not all, prior studies have suggested that patients with chronic liver disease are at increased risk of contracting COVID-19 and developing more severe disease. However, nationwide data lacking from well-phenotyped cohorts histology comparisons to matched general population controls.We conducted a cohort study all Swedish adults (CLD) confirmed by biopsy between 1966 2017 (n = 42,320), who were alive on February 1, 2020. CLD cases ≤ 5 comparators age, sex, calendar year county...

10.1186/s12876-021-02017-8 article EN cc-by BMC Gastroenterology 2021-11-23

Background and AimsAutoimmune hepatitis (AIH) is a chronic inflammatory liver disease that may lead to cirrhosis failure, but data on overall mortality in AIH are conflicting.MethodsThis was nationwide population-based cohort study Sweden from 1969-2017 of 6,016 adults with 28,146 matched general population reference individuals. defined by combination medical diagnosis plus biopsy any Sweden's 28 pathology departments. Through Cox regression, we estimated hazard ratios (HRs) for...

10.1016/j.cgh.2020.10.006 article EN cc-by Clinical Gastroenterology and Hepatology 2020-10-14

The liver transplantation (LT) population is aging, with the need for transplant being driven by growing prevalence of nonalcoholic steatohepatitis (NASH). Older LT recipients NASH may be at an increased risk adverse outcomes after LT. Our objective to characterize in these a large multicenter cohort. All primary ≥65 years from 2010 2016 13 centers Re‐Evaluating Age Limits Transplantation (REALT) consortium were included. Of 1023 recipients, 226 (22.1%) over 70 old, and 207 (20.2%) had NASH....

10.1002/lt.25863 article EN Liver Transplantation 2020-08-08

We aimed to determine the risk of incident cancer in autoimmune hepatitis (AIH) compared with general population and siblings. AIH was defined by presence a medical diagnosis results examination liver biopsy specimen nationwide Swedish population-based cohort study. identified 5,268 adults diagnosed during 1969-2016 22,996 matched, population, reference individuals 4,170 sibling comparators. Using Cox regression, hazard ratios were determined for any cancer, subtypes from Cancer Register....

10.1093/aje/kwab119 article EN American Journal of Epidemiology 2021-04-27

Abstract Background Low socioeconomic status has been linked with numerous poor health outcomes, but data are limited regarding the impact of insurance on inflammatory bowel disease (IBD) outcomes. We aimed to characterize utilization healthcare resources by IBD patients based status, using Medicaid enrollment as a proxy for low status. Methods retrospectively identified adult engaged in colorectal cancer surveillance colonoscopy program from July 2007 June 2017. Our primary outcomes...

10.1093/ibd/izz060 article EN Inflammatory Bowel Diseases 2019-04-16

Background: The aim of this study was to describe the prevalence comorbidity in newly diagnosed female breast cancer patients north-west India. second end point compliance for multimodality treatment. Comorbidity assessed by counting number coexisting diseases a patient or using index that combines and severity diseases. most widely used is Charlson Index (CCI). Materials Methods: data with were recorded, having comorbidities during registration treatment at host institute between January...

10.4103/1119-0388.185449 article EN Tropical Journal of Medical Research 2016-01-01

Background: Changes in adipose tissue distribution liver cirrhosis are poorly characterized and may affect clinical outcomes. Methods: Adult transplant (LT) January 2008–August 2017 recipients with abdominal MRI within 6 months pre-LT were retrospectively assessed. Visceral tissue, subcutaneous skeletal muscle area (cm 2 ) determined at L3. Visceral-to-subcutaneous ratio (VSR) was used to define relative distribution, stratified by sex. Correlation tested Pearson. Body composition measures...

10.1097/hc9.0000000000000113 article EN cc-by-nc-nd Hepatology Communications 2023-05-15

The risk for infection in alcohol-related liver disease (ALD) has rarely been investigated at a population level, nor if the underlying histopathology is associated with risk. We examined rate of hospital-based infections nationwide cohort biopsy-proven ALD, and subsequent death.Population-based study Sweden comparing 4028 individuals an international classification (ICD) code ALD biopsy from 1969 to 2017 19,296 matched general individuals. Swedish national registers were used ascertain...

10.1002/ueg2.12200 article EN cc-by-nc-nd United European Gastroenterology Journal 2022-01-28

Summary— Routine thermogravimetric (TG) analysis of 501 upper urinary calculi from the State Jammu and Kashmir is described. The technique simple, rapid quantitative, equipment easily maintained. was found to be helpful in 95.4% stones it suggested that TG may employed as a first choice routine quantitative all calculi.

10.1111/j.1464-410x.1989.tb05308.x article EN British Journal of Urology 1989-12-01

1Division of Digestive and Liver Diseases, Department Medicine, Columbia University Medical Center, New York, USA.

10.1038/ajg.2016.506 article EN The American Journal of Gastroenterology 2017-02-01

Autoimmune hepatitis (AIH) is a chronic inflammatory liver condition that predominantly affects women. However, pregnancy risks remain unclear.A nationwide population-based cohort study (ESPRESSO) in Sweden from 1992 to 2016 including 309 singleton births women with AIH and 1532 matched the general population was performed. diagnosed as combination of administrative coding medical diagnosis biopsy data Sweden's 28 pathology departments. Using conditional logistic regression, odds ratios...

10.1016/j.cgh.2021.12.024 article EN cc-by Clinical Gastroenterology and Hepatology 2021-12-23

<title>Abstract</title> <bold>Objectives</bold>: Celiac disease (CeD) has been associated with a low response to hepatitis B (HBV) vaccination, but guidelines for testing and revaccination among individuals CeD are sparse. We examined the risk of future HBV in population-based Swedish cohort. Furthermore, we rate prior infection patients. <bold>Methods</bold>: All Sweden diagnosed biopsy-verified between 1990-2017 were identified through ESPRESSO Each individual was matched by age, sex,...

10.21203/rs.3.rs-4401297/v1 preprint EN cc-by Research Square (Research Square) 2024-05-23

Identifying patients with rare diseases like alpha-1 antitrypsin deficiency (AATD) is challenging. Machine-learning models may be trained to identify using large-scale, real-world databases, whereas electronic medical records have low numbers of confirmed cases and limited use in training such models. We applied a machine-learning model large US claims database undiagnosed symptomatic AATD. Using deidentified data from the Komodo (April 26, 2016-January 31, 2023), was high probability Eighty...

10.1080/15412555.2024.2393348 article EN cc-by COPD Journal of Chronic Obstructive Pulmonary Disease 2024-09-23
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