A5085795388- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Diphtheria, Corynebacterium, and Tetanus
- Intramuscular injections and effects
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
- Vibrio bacteria research studies
- Vaccine Coverage and Hesitancy
- Antibiotic Resistance in Bacteria
- Bacillus and Francisella bacterial research
- Yersinia bacterium, plague, ectoparasites research
- Aquaculture disease management and microbiota
- SARS-CoV-2 and COVID-19 Research
- Listeria monocytogenes in Food Safety
- Parasites and Host Interactions
- Gut microbiota and health
- Trace Elements in Health
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Parasitic Infections and Diagnostics
- Reproductive tract infections research
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- RNA Interference and Gene Delivery
BioNTech (Germany)
2024
Max Planck Institute for Evolutionary Biology
2021-2023
Kiel University
2021-2023
Medizinische Hochschule Hannover
2018-2020
German Center for Infection Research
2018-2020
Kazan State Medical University
1995-1999
Kazan Research Institute of Epidemiology and Microbiology
1995-1997
In response to the 2022 outbreak of mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166, aiming create a highly immunogenic, safe, accessible, and scalable next-generation vaccine against MPXV related orthopoxviruses. To address multiple viral forms increase breadth immune response, two candidate multivalent mRNA vaccines were evaluated pre-clinically: quadrivalent (BNT166a; encoding antigens A35, B6, M1, H3) trivalent (BNT166c; without H3)....
Expression of ABO and Lewis histo-blood group antigens by the gastrointestinal epithelium is governed an α-1,2-fucosyltransferase enzyme encoded Fut2 gene. Alterations in mucin glycosylation have been associated with susceptibility to various bacterial viral infections. Salmonella enterica serovar Typhimurium a food-borne pathogen major cause gastroenteritis. In order determine role Fut2-dependent glycans Salmonella-triggered intestinal inflammation, Fut2+/+ Fut2-/- mice were orally infected...
Raw milk is a frequent vehicle for transmission of thermophilic Campylobacter, leading to reported outbreaks. Milk challenging food matrix pathogen detection, due its high protein and lipid content. Limited detection Campylobacter CFU in raw might underestimate the pathogen’s infectious potential. We optimized viability qPCR application with milk. The procedure was robust against variations lots different strains. Various DNA-intercalating dyes were evaluated their ability reduce PCR signal...
Countries with a high incidence of helminth infections are characterized by morbidity and mortality to intracellular pathogens such as Salmonella. Some patients Salmonella-Schistosoma co-infections develop so-called "chronic septicemic salmonellosis", prolonged fever enlargement the liver spleen. These effects most likely due overall immunoregulatory activities schistosomes induction Tregs, Bregs, alternatively activated macrophages, degradation antibodies. However, detailed underlying...
Abstract Background Salmonella enterica serovar Infantis (S. Infantis) is one of the ubiquitous serovars bacterial pathogen S. and recently has been emerging in many countries worldwide. Nonetheless, not much known about its epidemiology, host adaptation, virulence. Methods Epidemiological molecular approaches were used together with tissue-culture mouse models to conduct phenotypic comparison model Typhimurium. Results We show that more frequently associated infections infants <2 years...
Infectious disease is widely considered to be a major driver of evolution. A preponderance signatures balancing selection at blood group-related genes thought driven by inherent trade-offs in susceptibility disease. B4galnt2 subject long-term house mice, where two divergent allele classes direct alternative tissue-specific expression glycosyltransferase the intestine versus vessels. The vessel class leads prolonged bleeding times similar von Willebrand humans, yet has been maintained for...
Abstract Bacteria use type VI secretion systems (T6SSs) to deliver effector proteins into other cells or the extracellular space. Those effectors kill microbes 1 , manipulate eukaryotic 2 and sequester nutrients 3 . Which T6SS-mediated functions are generalisable across bacteria of a species specific particular strains is little known. Here, we genomics test for intraspecific diversity T6SS in opportunistic pathogen Pseudomonas aeruginosa We found that omnipresent conserved acting as ‘core...
Histo-blood group antigens in the intestinal mucosa play important roles host-microbe interactions and modulate susceptibility to enteric pathogens. The B4galnt2 gene, expressed GI tract of most mammals, including humans, encodes a beta-1,4-N-acetylgalactosaminyltransferase enzyme which catalyzes last step biosynthesis Sd(a) Cad blood by adding an N-acetylgalactosamine (GalNAc) residue precursor molecules. In our study, we found that loss expression is associated with increased Citrobacter...
Proteoglycans (PGs) are glycoconjugates which predominately expressed on cell surfaces and consist of glycosaminoglycans (GAGs) linked to a core protein. An initial step GAGs assembly is governed by the β-D-xylosyltransferase enzymes encoded in mammals XylT1/XylT2 genes. PGs essential for interaction with other cells as well extracellular matrix. A number studies highlighted role bacterial adhesion, invasion, immune response. In this work, we investigated Salmonella enterica serovar...
Tension of antidi phtheria immunity among uninoculated persons in various indicatory groups population Tatarstan Republic the presence epidemic process intensification is studied. It revealed that 44,576,5% inhabitants and classes titers were lower than protective. Taking into account a large percent unprotected absence financial material possibilities determining level before inoculation practice performing thrice-repeated adults older 30 justified.
Level of antidiphtherial immunity among indicatory groups Tatarstan Republic is studied for improving vaccinal prevention and developing management decisions recommendations. The increase antitoxic in aged 23 to 1617 its decrease with age rise especially persons 3637 4647 are noted. For revaccination 2627 it appropriate perform single immunization, 3637, 4647, 56 older selective immunization used taking into account the results passive hemagglutination reaction
The intensity of immunity to diphtheria and the indicated groups population in Tatarstan Republic is studied. work organization described allows, furthermore, perform a comparative analysis for various classes create data base realization similar perspective.
In recent years, the epidemic situation in diphtheria has deteriorated sharply. An essential point assessing dynamics of process is determination state immunity population. Judging by numerous publications [4-5], number immune persons and level antibodies them different years certain territories are different. Given that highest incidence currently observed among adults, we decided to study protection not total population, but adults. The intensity tetanus adult population Kazan was studied...