A5090144976- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Visual perception and processing mechanisms
- Advanced Memory and Neural Computing
- Cognitive Science and Mapping
- Motor Control and Adaptation
- Neural Networks and Applications
- Neural Networks and Reservoir Computing
- Neuroscience and Music Perception
- Zebrafish Biomedical Research Applications
- Biochemical Analysis and Sensing Techniques
- Action Observation and Synchronization
- Functional Brain Connectivity Studies
- Cognitive and developmental aspects of mathematical skills
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Multisensory perception and integration
- Insect Pheromone Research and Control
- Child and Animal Learning Development
- Human-Automation Interaction and Safety
- Face Recognition and Perception
- Decision-Making and Behavioral Economics
Instituto de Neurociencias
2019-2023
Consejo Superior de Investigaciones Científicas
2019-2023
Universitat de Miguel Hernández d'Elx
2019-2022
Sapienza University of Rome
2015-2021
Universitat Pompeu Fabra
2009-2015
Universitat Politècnica de Catalunya
2011
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2011
Institució Catalana de Recerca i Estudis Avançats
2011
Our decisions often depend on multiple sensory experiences separated by time delays. The brain can remember these and, simultaneously, estimate the timing between events. To understand mechanisms underlying working memory and encoding, we analyze neural activity recorded during delays in four experiments nonhuman primates. disambiguate potential mechanisms, propose two analyses, namely, decoding passage of from data computing cumulative dimensionality trajectory over time. Time be decoded...
Perceptual decision making has been widely studied using tasks in which subjects are asked to discriminate a visual stimulus and instructed report their with movement. In these studies, performance is measured by assessing the accuracy of participants' choices as function ambiguity stimulus. Typically, reporting movement considered mere means no influence on decision-making process. However, recent studies have shown that even subtle differences biomechanical costs between movements may how...
Perceptual decision making is often modeled as perfect integration of sequential sensory samples until the accumulated total reaches a fixed bound. In that view, buildup neural activity during perceptual attributed to temporal integration. However, an alternative explanation estimates are computed quickly with low-pass filter and combined growing signal reflecting urgency respond it latter primarily responsible for buildup. These models difficult distinguish empirically because they make...
In previous work, we studied the activity of neurons in dorsolateral (PFdl), orbital (PFo), and polar (PFp) prefrontal cortex while monkeys performed a strategy task with 2 spatial goals. A cue instructed 1 strategies each trial: stay goal or shift to alternative goal. Each trial started fixation period, followed by cue. Subsequently, delay period was "go" signal that choose one After choice, feedback provided. this study, focused on temporal receptive fields neurons, as measured decay...
Alcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes. The neuroadaptations underlying this aberrant behavior are poorly understood. Using an animal model of alcohol use disorders (AUD) complementing diffusion-weighted (dw)-MRI with quantitative immunohistochemistry electrophysiological recordings, we provide causal evidence that chronic intermittent exposure affects the microstructural integrity fimbria/fornix, decreasing...
The estimation of space and time can interfere with each other, neuroimaging studies have shown overlapping activation in the parietal prefrontal cortical areas. We used duration distance discrimination tasks to determine whether share resources cortex (PF) neurons. Monkeys were required report which two stimuli, a red circle or blue square, presented sequentially, longer farther, respectively, tasks. In previous study, we showed that relative are coded by different populations neurons only...
When choices are made freely, they might emerge from pre-existing neural activity. However, whether neurons in the prefrontal cortex (PF) show this anticipatory effect and, if so, which part of process involved is still debated. To answer question, we studied PF activity monkeys while performed a strategy task. In task when stimulus changed previous trial, had to shift their response 1 2 spatial goals, excluding one that been previously selected. Under free-choice condition, prestimulus same...
Representing others' intentions is central to primate social life. We explored the role of dorsal premotor cortex (PMd) in discriminating between self and behavior while two male rhesus monkeys performed a non-match-to-goal task monkey-human paradigm. During each trial, four potential targets were randomly presented on right left parts screen, monkey or human was required choose one that did not match previously chosen target. Each agent had monitor other's action order select correct target...
Our decisions often depend on multiple sensory experiences separated by time delays. The brain can remember these and, simultaneously, estimate the timing between events. To understand mechanisms underlying working memory and encoding we analyze neural activity recorded during delays in four experiments non-human primates. disambiguate potential mechanisms, propose two analyses, namely, decoding passage of from data, computing cumulative dimensionality trajectory over time. Time be decoded...
The prefrontal cortex (PF) is involved in outcome-based flexible adaptation a dynamically changing environment. outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine issue, we analyzed outcome-related activity PF neurons 2 monkeys distance discrimination task. initial prestimulus period task varied duration, allowing us to dissociate effects time and event on decline previous -previous correct versus error. We observed types...
Abstract Psychedelic agonists of serotonin receptors induce neural plasticity and synaptogenesis, but their potential to enhance learning remains uncharted. Here we show that a single dose d-LSD, potent serotonergic agonist, increased novel object preference in young adult rats several days after treatment. d-LSD alone did not increase old animals, could rescue it levels when followed by 6-day exposure enriched environment (EE). Mass spectrometry-based proteomics human brain organoids...
Sequence learning tasks depend on the ability to acquire and control order of actions their proper timing. Several studies have shown that in sequence different areas brain are involved when recalling interval. One hypothesis proposes two separate interact with each other, one computes while other would compute A second area both, To better understand how this computation interval might be realized by brain, we developed a robot based architecture investigated behavioral architectural...
Perceptual decision-making has been widely studied using tasks in which subjects are presented with a visual stimulus and instructed to select between two alternative options, based on feature of the stimulus. Several studies have reported that subjects' performance depends difficulty indentify specific feature. However, if we view as continuous process includes not only perceptual discrimination but also motor action one would expect cost this will an impact during preparation phase. We...
A standard view in the literature is that decisions are result of a process accumulates evidence favor each alternative until such accumulation reaches threshold and decision made. However, this has been recently questioned by an proposal suggests that, instead accumulated, combined with urgency signal. Both theories have mathematically formalized supported variety decision-making tasks constant information. recently, changing information shown to be more effective study dynamics making....
Foraging can be described as goal-oriented exploration for resources. It exemplifies how animals coordinate complex sensory and effector systems under varying environmental conditions. To emulate the foraging capabilities of natural is a major goal robotics. Therefore, an excellent paradigm to benchmark novel autonomous control strategies. Here we describe biomimetic architecture Synthetic Forager (SF), effort integrate multiple biologically constrained models specific perceptual cognitive...