A5085986209- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Biofuel production and bioconversion
- Biochemical Analysis and Sensing Techniques
- Venomous Animal Envenomation and Studies
- Computational Drug Discovery Methods
- Chemical synthesis and alkaloids
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Various Chemistry Research Topics
- Enzyme Catalysis and Immobilization
- Antimicrobial Peptides and Activities
- Synthesis and biological activity
- Hearing, Cochlea, Tinnitus, Genetics
- Bacillus and Francisella bacterial research
- GABA and Rice Research
- Aortic aneurysm repair treatments
- Clay minerals and soil interactions
- Quinazolinone synthesis and applications
- Trypanosoma species research and implications
- Transgenic Plants and Applications
- Polyamine Metabolism and Applications
- Aortic Disease and Treatment Approaches
- Neuroscience and Neuropharmacology Research
- Infectious Aortic and Vascular Conditions
Universidade Federal do Rio Grande do Norte
2014-2025
Instituto do Cérebro de Brasília
2020
Hospital Felício Rocho
1998
Scorpion venom constitutes a rich source of biologically active compounds with high potential for therapeutic and biotechnological applications that can be used as prototypes the design new drugs. The aim this study was to characterize structural conformation, evaluate antimicrobial activity, gain insight into possible action mechanism underlying it, two analog peptides scorpion peptide Stigmurin, named StigA25 StigA31. amino acid substitutions in native sequence lysine residues resulted...
Saccharification of lignocellulosic material by xylanases and other glycoside hydrolases is generally conducted at high concentrations the final reaction products, which frequently inhibit enzymes used in saccharification process. Using a random nonhomologous recombination strategy, we have fused GH11 xylanase from Bacillus subtilis (XynA) with xylose binding protein Escherichia coli (XBP) to produce an enzyme that allosterically stimulated xylose.The pT7T3GFP_XBP plasmid containing XBP...
Abstract Cancer is defined as a group of diseases in which abnormal cells multiply and can invade other organs, requiring continuous studies for new drugs. A series 177 imidazo[1,2-a]pyridine imidazo[1,2-a] pyrazine synthetic derivatives were previously obtained, their anti-melanoma IC50 values have been determined. Here, Artificial Intelligence algorithms used to select molecular descriptors build QSAR model, highlighting structural characteristics related enhanced potency. Additionally,...
The binding constant and stoichiometry ratio for the formation of iron(II)–(1,10-phenanthroline) or iron(II)–o-phenanthroline complexes has been determined by a combination low-cost analytical method using smartphone molecular modeling as laboratory experiment designed physical chemistry courses. Intensity values were obtained from digital images measuring RGB (red, green, blue) (on scale 0–255 in intensity) samples between Fe(II) o-phenanthroline camera smartphone. R channel showed best...
Introduction: N,N-Dimethyltryptamine (DMT), a naturally occurring psychedelic tryptamine contained in the indigenous ayahuasca brew, has shown antidepressant effects. This open-label clinical trial investigates for first time efficacy of vaporized DMT treatment-resistant depression (TRD).
Quinoxaline derivatives have attracted considerable attention due to their vast range of applications that includes electroluminescence and biomedicine.
Anionic peptides of scorpions are molecules rich in aspartic and/or glutamic acid residues and correspond to a class without disulfide bonds that still little explored. TanP is linear anionic peptide (50 amino net charge −20) present the venom gland scorpion, Tityus stigmurus , with chelating properties for Cu 2+ ion immunomodulatory properties. The therapeutic application related cases acute or chronic intoxication by metals, neurodegenerative diseases, hematological healing skin wounds,...
Abstract Introduction N,N-Dimethyltryptamine (DMT), a naturally occurring psychedelic tryptamine contained in the indigenous ayahuasca brew has shown antidepressant effects. This Phase 2a clinical trial investigates for first time efficacy of isolated DMT treatment-resistant depression (TRD). Methods Six TRD patients participated an open-label, fixed-order, dose-escalation study, receiving lower (15 mg) and then higher (60 dose vaporized single-day session. Depression severity was assessed...
Detailed binding energies features of interdomain allosteric modulation caused by xylose for enhanced xylanolytic activity on xylanase-XBP chimera.
Tinnitus is a phantom sound perception affecting both auditory and limbic structures. The mechanisms of tinnitus remain unclear it debatable whether alters attention to the ability inhibit repetitive sounds, phenomenon also known as gating. Here we investigate if noise exposure interferes with gating natural extracts cannabis or nicotine could improve pre-attentional processing in noise-exposed mice. We used 22 male C57BL/6J mice divided into (exposed 9-11 kHz narrow band for 1 h) sham (no...
AnalyticalChemistry books lack a clear link between thermodynamic and equilibrium approaches involving acids bases.In this work, theoretical calculations were performed to search for these relations.An excellent relationship was found difference in Gibbs free energy, ∆G of acid dissociation reaction hydrolysis the corresponding conjugate base.A their atomic radius also identified, showing that stability plays an important role reactions.Finally, importance solvation acid/base behavior...
No período de outubro 1989 a maio 1997, 40 pacientes portadores dissecção aórtica, aneurisma da aorta, coarctação aorta ou doença oclusiva aorto-ilíaca foram submetidos reconstrução utilizando-se conduto pericárdio bovino corrugado processado em glutaraldeído. A total ascendente com substituição valva aórtica e reimplante das artérias coronárias foi realizada 9 pacientes, simples 6, torácica descendente 2, arco aórtico 1, toracoabdominal 1 abdominal reconstruída 21, incluindo aorto-femoral....
Abstract Tinnitus is a phantom sound perception affecting both auditory and limbic structures. The mechanisms of tinnitus remain unclear it debatable whether alters attention to the ability inhibit repetitive sounds, phenomenon also known as gating. Here we investigate if noise exposure interferes with gating natural extracts cannabis or nicotine could improve pre-attentional processing in noise-exposed mice. We used 22 male C57BL/6J mice divided into (exposed 9-11 kHz narrow band for 1...