A5004866410- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Vibrio bacteria research studies
- Cardiac electrophysiology and arrhythmias
- Yersinia bacterium, plague, ectoparasites research
- Probiotics and Fermented Foods
- Bacterial Identification and Susceptibility Testing
- Celiac Disease Research and Management
- Microbial Community Ecology and Physiology
- Protist diversity and phylogeny
Federal Medical-Biological Agency
2021-2025
Introduction Bacteroides fragilis (Bf)’s T6SS locus has been characterized and shown to have functional activity in competition experiments. It demonstrated that symbiont nontoxigenic Bf strains a more effective “weapon” effect on pathogenic Bf, which is realized through the of effector-immune (E-I) protein pairs. Intensive study structure led an understanding certain issues related its activity, but exact regulatory mechanisms E-I pair remain unclear. Proteomic annotation components...
Microorganisms and their hosts communicate with each other by secreting numerous components. This cross-kingdom cell-to-cell signaling involves proteins small molecules, such as metabolites. These compounds can be secreted across the membrane via transporters may also packaged in outer vesicles (OMVs). Among components, volatile (VOCs) are of particular interest, including butyrate propionate, which have proven effects on intestinal, immune, stem cells. Besides short fatty acids, groups...
ABSTRACT Inflammatory bowel diseases are characterized by chronic intestinal inflammation and alterations in the gut microbiota composition. Bacteroides fragilis , which secretes outer membrane vesicles (OMVs) with polysaccharide A (PSA), can moderate inflammatory response possibly alter In this study, we created a murine model of sodium dextran sulfate (DSS)-induced colitis treated it B. OMVs. We monitored efficiency OMV therapy determining disease activity index (DAI) performing...
Crohn's disease (CD) is a chronic relapsing inflammatory bowel of unknown etiology. Genetic predisposition and dysbiotic gut microbiota are important factors in the pathogenesis CD. In this study, we analyzed taxonomic composition genotypes 24 single nucleotide polymorphisms (SNP) associated with risk The studied cohorts included 96 CD patients healthy volunteers from Russia. Statistically significant differences were found allele frequencies for 8 SNPs compared controls. addition, two types...
Abstract Background/Aims: Inflammatory bowel diseases are extremely common throughout the world. However, in most cases its asymptomatic at initial stage. Therefore, it is important to develop non-invasive diagnostic methods that allow identification of IBD risks timely manner. It’s well known gastrointestinal microbiota secreted volatile compounds (VOCs) and composition may change IBD. We propose a method identify dynamics development acute remission stage level VOCs stool rats with...
Abstract Inflammatory bowel diseases are characterized by chronic intestinal inflammation and alterations of gut microbiota composition. Bacteroides fragilis , which secretes outer membrane vesicles (OMVs) with polysaccharide A (PSA), can moderate inflammatory response possibly alter In this research, we created a murine model DSS- induced colitis treated it OMVs. We monitored the efficiency OMVs therapy determining disease activity index (DAI) histological examination (HE) intestine before...
Inflammatory bowel diseases are extremely common throughout the world. However, in most cases, it is asymptomatic at initial stage. Therefore, important to develop non-invasive diagnostic methods that allow identification of IBD risks a timely manner. It well known gastrointestinal microbiota secrete volatile compounds (VOCs) and their composition may change IBD. We propose method identify dynamics development acute remission stage level VOCs model dextran sulfate sodium (DSS) with...
Primary cardiac channelopathies are a group of diseases wherein the role DNA testing in aiding diagnosis and treatment-based decision-making is gaining increasing attention. However, some cases, evaluating pathogenicity new variants still challenging. We report an accurate multistage assessment rare genetic variant SCN5A gene using next-generation sequencing (NGS) techniques Sanger sequencing. Female sportsman (14 years old) underwent counseling due to QT interval prolongation registered...