A5078221232- interferon and immune responses
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Water Treatment and Disinfection
- Food Quality and Safety Studies
- Immune Response and Inflammation
- Genetic Neurodegenerative Diseases
- Probiotics and Fermented Foods
- Topic Modeling
- RNA modifications and cancer
- Food composition and properties
- Biofuel production and bioconversion
- Nuclear Receptors and Signaling
- Viral gastroenteritis research and epidemiology
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phytochemical and Pharmacological Studies
- Speech and dialogue systems
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Inflammasome and immune disorders
- Proteins in Food Systems
- Peroxisome Proliferator-Activated Receptors
- Nuclear materials and radiation effects
Institute of Automation
2024
Chinese Academy of Sciences
2012-2024
Hebei Medical University
2024
First Affiliated Hospital of Hebei Medical University
2024
Henan Agricultural University
2023
Institute of High Energy Physics
2023
Beijing University of Chemical Technology
2023
Case Western Reserve University
2018-2022
University School
2018-2022
Research Center for Eco-Environmental Sciences
2015-2022
Innate antiviral immunity is the first line of host defense system that rapidly detects invading viruses. Mitochondria function as platforms for innate signal transduction in mammals through adaptor protein, MAVS. Excessive activation MAVS-mediated signaling leads to dysfunction mitochondria and cell apoptosis likely causes pathogenesis autoimmunity. However, mechanism how MAVS regulated at remains unknown. Here we show Cytochrome c Oxidase (CcO) complex subunit COX5B physically interacts...
Abstract Mitochondrial fragmentation and bioenergetic failure manifest in Huntington’s disease (HD), a fatal neurodegenerative disease. The factors that couple mitochondrial fusion/fission with bioenergetics their impacts on neurodegeneration however remain poorly understood. Our proteomic analysis identifies protein ATAD3A as an interactor of fission GTPase, Drp1, HD. Here we show that, HD, dimerization due to deacetylation at K135 residue is required for Drp1-mediated fragmentation....
Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation, however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA-domain containing protein 3A (ATAD3A), a mitochondrial AAA-ATPase, as molecular switch that links cholesterol impairment AD phenotypes. In neuronal models of AD, 5XFAD mouse model and post-mortem brains, ATAD3A is oligomerized accumulated at mitochondria-associated ER membranes (MAMs), where it induces accumulation by...
Ammonium is a preferred source of nitrogen for plants but toxic at high levels. Plant ammonium transporters (AMTs) play an essential role in NH 4 + uptake, the mechanism by which AMTs are regulated remains unclear. To study how presence ammonium, we used variable-angle total internal reflection fluorescence microscopy and cross-correlation spectroscopy single-particle imaging EGFP-tagged AMT1;3 on plasma membrane Arabidopsis root cells various We demonstrated that AMT1;3-EGFP dynamically...
Abstract Mitochondrial antiviral signalling protein (MAVS) acts as a critical adaptor to transduce by physically interacting with activated RIG-I and MDA5 receptors. MAVS executes its functions at the outer membrane of mitochondria regulate downstream signalling, indicating that provides functional platform for innate transduction. However, little is known about whether how MAVS-mediated contributes mitochondrial homeostasis. Here we show activation sufficient induce autophagic which may...
Lipogenesis is required for the optimal growth of many types cancer cells, it shown to control biosynthesis lipid bilayer membrane during rapid proliferation and metastasis, provides cells with signaling molecules support development make more resistant oxidative stress-induced cell death. Though multiple lipogenic enzymes have been identified mediate this metabolic change, how expression these are transcriptionally regulated remains unclear. Gain- loss-of-function experiments were conducted...
The fate of radionuclides in the environment is attracting increased attention. effect various environmental effects on adsorption behavior strontium ion (Sr2+) by red soil colloids Southern China was studied a series batch experiments, and mechanism briefly investigated as well. With increase solid–liquid ratio concentration Sr2+, efficiency gradually. pH ionic strength strong, while temperature had little effect. data fitted to Langmuir model indicates that process monolayered homogeneous....
Mn(II) oxidation by free chlorine can be applied to remove at water treatment plants. This reaction also results in particulate MnOx formation and accumulation drinking distribution systems. study investigated the effect of Fe(III) Al(III) hydrolysis products (mainly precipitates) on under conditions. The showed that Fe3+ added as FeCl3 polyaluminum chloride (PACl) tens hundreds micrograms per liter dramatically catalyzed chlorine. Through hydrolytic precipitation circumneutral pH, Al13 (the...
Background In the treatment of depression, medication plays a crucial role. However, insufficient patient adherence to often results in unsatisfactory outcomes, increasing both recurrence and rehospitalization rates consequently imposing greater economic burden on healthcare system. Objectives Our objective was examine impact pharmacogenomic testing antidepressant switching among individuals diagnosed with depression. Methods This retrospective cohort study encompassed patients depression...