A5101425795- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Utilization and Effects
- Genomics and Phylogenetic Studies
- Developmental Biology and Gene Regulation
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Genetics, Aging, and Longevity in Model Organisms
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- interferon and immune responses
- Oral microbiology and periodontitis research
- Plant Parasitism and Resistance
- Antimicrobial Peptides and Activities
- TGF-β signaling in diseases
- Viral Infections and Vectors
- Wnt/β-catenin signaling in development and cancer
- Bacterial biofilms and quorum sensing
- Microtubule and mitosis dynamics
- Bacterial Identification and Susceptibility Testing
Anhui Agricultural University
2017-2025
Centre National de la Recherche Scientifique
2024
Institut de Biologie Moléculaire et Cellulaire
2024
Innate Pharma (France)
2024
Université de Strasbourg
2023
Institute of Zoology
2014-2019
Chinese Academy of Sciences
2014-2019
Zhejiang University
2011-2013
Sir Run Run Shaw Hospital
2013
Wuhan University
2009
We report the complete sequence of a paralogous copy elongation factor-1 alpha (EF-1 alpha) in honeybee, Apis mellifera (Hymenoptera: Apidae). This differs from previously described positions five introns and 25% nucleotide sites coding regions. The existence two copies EF-1 Drosophila suggests that may be widespread holometabolous insect orders. To distinguish between single, ancient gene duplication parallel, independent fly bee duplications, we performed phylogenetic analysis hexapod...
Innate immunity mediated by Toll signalling has been extensively studied, but how is precisely controlled in balancing innate immune responses remains poorly understood. It was reported that the plasma membrane localization of Drosophila MyD88 necessary for recruitment cytosolic adaptor Tube to cell surface, thus contributing transduction. Here we demonstrate Pellino functions as a negative regulator Toll-mediated signalling. We show accumulates at upon activation MyD88-dependent manner....
Significance Previous studies have demonstrated that Bam protein plays a critical role promoting early germ-line cell differentiation in the Drosophila ovary. Although its regulation and genetic functions been extensively investigated over last 20 years, biochemical nature of has still remained elusive. Here, we show as an ubiquitin-associated regulates stability CycA. Our study uncovers mechanism by which protein, cooperates with Otu to deubiquitinate stabilize CycA, thereby balancing GSC...
Black tea is the most widely consumed drink in world and has consistently been reported to possess anti-aging benefits. However, whether theaflavins, one type of characteristic phytochemicals black extracts, are involved regulating aging lifespan consumers remains largely unknown. In this study, we show that theaflavins play a beneficial role preventing age-onset intestinal leakage dysbiosis, thus delaying Drosophila. Mechanistically, regulate condensate assembly Imd negatively govern...
Toll signaling is well known for its pivotal role in the host response against invasion of external pathogens. Here, we investigate potential involvement intersection between and oncogenic cells. We show that loss myeloid differentiation factor 88 (Myd88) leads to drastic fly death after injection RasV12-GFP Transcriptomic analyses challenging flies with cells or bacteria distinct inductions Myd88-dependent genes. note downregulation Myd88 tracheal system accounts mortality, ectopic...
Abstract Eukaryotic translation initiation factors have long been recognized for their critical roles in governing the of coding RNAs into peptides/proteins. However, whether they harbor functional activities at post-translational level remains poorly understood. Here, we demonstrate that eIF3f1 ( eukaryotic factor 3 subunit f1 ), which encodes an archetypal deubiquitinase, is essential antimicrobial innate immune defense Drosophila melanogaster . Our vitro and vivo evidence indicate...
Abstract The Drosophila melanogaster (fruit fly) misexpression suppressor of Ras 4 (MESR4) gene encodes a potential transcription factor and plays critical roles in various biological processes, including embryonic development, lipid metabolism, eye–antennal germline stem cell differentiation. However, whether it is involved modulating intestinal homeostasis remains elusive. In this study, we provide compelling evidence demonstrating that MESR4 bona fide regulator preventing age‐onset...
Cullin 2 (Cul2), a core component of the Cullin-RING E3 ubiquitin ligase complex, is integral to regulating distinct biological processes. However, its role in innate immune defenses remains poorly understood. In this study, we investigated functional significance Cul2 deficiency (IMD) signaling-mediated antimicrobial reactions Drosophila melanogaster (fruit fly). We demonstrated that loss-of-function led marked reduction peptide induction following bacterial infection, which was associated...
The intestine, a high-turnover tissue, plays critical role in regulating aging and health both vertebrates invertebrates.Maintaining the epithelial barrier function of intestine by preserving innate immune homeostasis significantly delays prevents mortality.In an effort to explore effective chemicals materials that can improve intestinal integrity, we performed nonbiased screen utilizing Drosophila as animal model.We showed long-term uptake aspirin markedly prevented age-onset gut leakage,...
Negative regulators of the inflammatory responses are essential for maintenance immune homeostasis and organismal fitness. In Drosophila , deubiquitinase (Dub) dTrbd selectively restricts K63-linked ubiquitination modification dTak1, a pivotal kinase IMD signaling pathway, to regulate innate response. However, which domain how it functions enable dTrbd’s activity remain unexplored. Here, we provide compelling evidence showing that NZF is its association with dTak1. Meanwhile, Linker region...
In Drosophila , the endoplasmic reticulum-associated protein degradation (ERAD) is engaged in regulating pleiotropic biological processes, with regard to retinal degeneration, intestinal homeostasis, and organismal development. The extent which it functions controlling fly innate immune defense, however, remains largely unknown. Here, we show that blockade of ERAD fat bodies antagonizes Toll but not IMD defense . Genetic approaches further suggest a functional role Me31B ERAD-mediated...
Significance Inhibitory Smads (I-Smads) play important roles to negatively regulate TGF-β/BMP (bone morphogenetic protein) signaling, thus controlling numerous cellular and developmental processes. Recent studies have suggested that Smad7, a member of I-Smads, is overexpressed in cancer types its abundance positively correlated the malignancy. However, molecular mechanism underlying action I-Smads cells remains poorly understood. Here we show Drosophila I-Smad, Dad, accesses membrane via...
The bee genus Lasioglossum includes > 1,000 species of bees distributed on all continents except Antarctica. is a major component the fauna in Holarctic, Ethiopian, and Asian regions an important group for investigating evolution social behavior bees. Given its cosmopolitan distribution, historical biogeography considerable interest. We reconstructed phylogenetic relationships among subgenera within s.s., using DNA sequence data from slowly evolving nuclear gene, elongation factor-1 alpha....
A polyphasic taxonomic approach was used to study strain 12116T, which isolated from desert sand in Xinjiang, China. Cells of the isolate were Gram-negative, non-motile, rod-shaped and aerobic. MK-7 predominant respiratory menaquinone. The DNA G+C content 46.3 mol%. phylogenetic analysis based on 16S rRNA gene sequences showed that most closely related members genus Dyadobacter, with similarities ranging 94.7 96.6 %. Therefore, basis genotypic phenotypic data, 12116T represents a novel...
Aspirin, also known as acetylsalicylic acid, is widely consumed a pain reliever and an anti-inflammatory well anti-platelet agent. Recently, our studies using the animal model of Drosophila demonstrated that dietary supplementation aspirin renovates age-onset intestinal dysfunction delays organismal aging. Nevertheless, it remains probable plays functional roles in other biological activities, for instance antiviral defense reactions. Intriguingly, we observed replications several types...
Background: Drosophila ubiquitin carboxy-terminal hydrolase L5 (Uch-L5) functions as a critical component of the 26S proteasome to mediate degradation polyubiquitinated proteins. It was recently shown modulate tissue/organ development by targeting Smoothened protein in hedgehog pathway. However, whether it plays role controlling organismal immune response remains largely unknown. Methods: Reverse transcription plus quantitative polymerase chain reaction (RT-qPCR), dual-luciferase, and...