A5012130650- Spinal Cord Injury Research
- Cardiac Arrest and Resuscitation
- Spinal Dysraphism and Malformations
- Trauma and Emergency Care Studies
- Nerve injury and regeneration
- Cerebral Palsy and Movement Disorders
- Neuroscience of respiration and sleep
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Infectious Diseases and Tuberculosis
- Thermal Regulation in Medicine
- Traumatic Brain Injury Research
- Pain Mechanisms and Treatments
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Extracellular vesicles in disease
- Respiratory Support and Mechanisms
- Medical and Health Sciences Research
- Seaweed-derived Bioactive Compounds
- Axon Guidance and Neuronal Signaling
- Lysosomal Storage Disorders Research
- Takotsubo Cardiomyopathy and Associated Phenomena
Freie Universität Berlin
2017-2024
Humboldt-Universität zu Berlin
2017-2024
Charité - Universitätsmedizin Berlin
2014-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018-2024
Inova Fairfax Hospital
2024
The Ohio State University Wexner Medical Center
2017-2023
International Collaboration On Repair Discoveries
2020
University of British Columbia
2020
ETH Zurich
2020
Spinal Injuries Center
2020
Pneumonia is the leading cause of death after acute spinal cord injury and associated with poor neurological outcome. In contrast to current understanding, attributing enhanced infection susceptibility solely patient’s environment motor dysfunction, we investigate whether a secondary functional neurogenic immune deficiency (spinal injury-induced syndrome, SCI-IDS) may account for susceptibility. We applied clinically relevant model experimental induced pneumonia systemic SCI-IDS sufficient...
Infections are a common threat to patients after spinal cord injury. Furthermore, infections might propagate neuronal death, and consequently contribute the restriction of neurological recovery. We investigated association (i.e. pneumonia and/or postoperative wound infections) with functional outcome acute severe traumatic screened data sets 24 762 enrolled in prospective cohort study (National Spinal Cord Injury Database, Birmingham, AL, USA). Patients were assessed according ASIA...
Resolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity and remodeling leads to functional deficits. Effective pharmacological treatments for SCI are not currently available. Maresin 1 (MaR1) a highly conserved specialized proresolving mediator (SPM) hosting potent anti-inflammatory properties with regenerative actions. Here, we provide evidence that the inappropriate biosynthesis SPM in lesioned hampers resolution deleterious consequences on...
To investigate whether prevalent hospital-acquired pneumonia and wound infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI).This was a longitudinal cohort study within prospective multicenter National Spinal Cord Injury Database (Birmingham, Alabama). We screened datasets of 3,834 patients enrolled in 20 trial centers from 1995 to 2005 followed up until 2016. Eligibility criteria were cervical SCI American Association impairment scale A, B, C....
The comprehensive expansion of the Trauma Register German Society (Deutsche Gesellschaft für Unfallchirurgie; TR-DGU) now enables, for first time, studies on traumatic brain injury (TBI) with special attention to care processes, clinical course, and outcomes treatment discharge or transfer from acute-care hospital.Retrospective analysis patients documented in TR-DGU period 2013-2017 who had moderate severe head as defined by Abbreviated Injury Scale (AIS).In 2013-2017, 41 101 TBI were...
Inflammatory resolution is an active, highly regulated process already encoded at the onset of inflammation and required to prevent transition into chronic associated with spreading tissue injury exacerbated scarring. We introduce objective, quantitative measurements [resolution indices (R(i) ) plateau (R(P) )] characterize inflammatory determine persistence ("dwell time") differential leukocyte subpopulations lesion site after acute experimental spinal cord (SCI). The cell type-specific...
Acute traumatic spinal cord injury (SCI) induces a systemic immune response involving circulating white blood cells (WBCs). How this is influenced by overall trauma severity, the neurological level of and/or correlates with patient outcomes poorly understood. The objective study was to identify relationships between early changes in WBCs, characteristics and long-term individuals SCI.
Abstract Clostridium botulinum C3 transferase (C3bot) ADP‐ribosylates rho proteins to change cellular functions in a variety of cell types including astrocytes and neurons. The intermediate filament protein vimentin as well transmembrane integrins are involved internalization C3bot into cells. exact contribution, however, these binding the surface subsequent uptake remains be unraveled. By comparing primary astrocyte cultures derived from wild‐type with Vim −/− mice, we demonstrate that...
Abstract Infections are prevalent after spinal cord injury (SCI), constitute the main cause of death and a rehabilitation confounder associated with impaired recovery. We hypothesize that SCI causes an acquired lesion-dependent (neurogenic) immune suppression as underlying mechanism to facilitate infections. The international prospective multicentre cohort study (SCIentinel; protocol registration DRKS00000122; n = 111 patients) was designed distinguish neurogenic from general trauma-related...
Abstract We show that redox active iron can induce a regulated form of non-apoptotic cell death and tissue damage called ferroptosis contribute to secondary functional loss in the acute chronic periods after spinal cord injury (SCI) young, adult, female mice. Phagocytosis red blood cells at sites hemorrhage is main source derived from hemoglobin SCI. Expression hemeoxygenase-1 induces release heme, increased macrophages 7 days injury. While stored safely ferritin injured cord, it can,...
Infections are the leading cause of death in acute phase following spinal cord injury and qualify as independent risk factor for poor neurological outcome ("disease modifying factor"). The enhanced susceptibility infections is not stringently explained by increased aspiration tetraplegic patients, neurogenic bladder dysfunction, or high-dose methylprednisolone treatment. Experimental clinical pilot data suggest that disrupts balanced interplay between central nervous system immune system....
Semaphorin 7A (Sema7A) is involved in the formation of central nervous system during development by operating axon guidance and neuronal migration. We investigated expression TGFβ-inducible Sema7A following spinal cord injury (SCI). After SCI, Sema7A(+) cells accumulated specifically lesion areas resulting significantly enhanced at site (P < 0.0001). During first days lesional was confined to neurons, ballooned neurite fibers/retraction bulbs, endothelial cells. At day 7, we observed...
Aim of this study was to investigate the mechanism/s associating hepatitis C virus (HCV) infection and posttransplant diabetes mellitus in kidney recipients. Twenty HCV-positive 22 HCV-negative recipients, 14 nontransplant patients 24 (healthy) subjects were analyzed. A 3-h intravenous glucose tolerance test performed; peripheral insulin sensitivity assessed by minimal modeling. Pancreatic secretion, hepatic uptake, pancreatic antibodies proinflammatory cytokines serum (tumor necrosis...
Abstract Comorbidity scores are important predictors of in-hospital mortality after traumatic spinal cord injury (tSCI), but the impact specific pre-existing diseases is unknown. This retrospective cohort study aims at identifying relevant comorbidities and explores influence end-of-life decisions. In-hospital all patients admitted to center acute tSCI from 2011 2017 was assessed. A conditional inference tree analysis including baseline data, characteristics, Charlson Index items used...
The approved analgesic and anti-inflammatory drugs ibuprofen indometacin block the small GTPase RhoA, a key enzyme that impedes axonal sprouting after damage. Inhibition of Rho pathway in central nervous system-effective manner requires higher dosages compared with orthodox cyclooxygenase-blocking effects. Preclinical studies on spinal cord injury (SCI) imply improved motor recovery ibuprofen/indometacin-mediated inhibition. This has been reassessed by meta-analysis underlying experimental...
<h3>Background and Objectives</h3> Spinal cord injury (SCI) disrupts the fine-balanced interaction between CNS immune system can cause maladaptive aberrant responses. The study examines emerging autoantibody synthesis after SCI with binding to conformational spinal epitopes surface peptides located on intact neuronal membrane. <h3>Methods</h3> This is a prospective longitudinal cohort conducted in acute care inpatient rehabilitation centers conjunction neuropathologic case-control archival...