A5022954019- Economic and Financial Impacts of Cancer
- Biomedical Text Mining and Ontologies
- Bioinformatics and Genomic Networks
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Scientific Computing and Data Management
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Ethics in Clinical Research
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Semantic Web and Ontologies
- LGBTQ Health, Identity, and Policy
- Chemical Synthesis and Analysis
- Genetics, Bioinformatics, and Biomedical Research
- Electronic Health Records Systems
- Health Systems, Economic Evaluations, Quality of Life
- Gastric Cancer Management and Outcomes
- Digital Radiography and Breast Imaging
Zephyr Software (United States)
2023-2024
American Society of Clinical Oncology
2019-2022
National Center for Biotechnology Information
2015
National Institutes of Health
2006-2015
National Cancer Institute
2006-2015
Center for Information Technology
2009
United States Department of Health and Human Services
2006
Human Genome Sciences (United States)
2003
University of Southern California
1997
California Institute of Technology
1987-1997
Summary OmicCircos is an R software package used to generate high-quality circular plots for visualizing genomic variations, including mutation patterns, copy number variations (CNVs), expression and methylation patterns. Such can be displayed as scatterplot, line, or text-label figures. Relationships among features in different chromosome positions represented the forms of polygons curves. Utilizing statistical graphic functions R/Bioconductor environment, performs analyses displays results...
Understanding the human condition is a Big Data problem. This statement nicely illustrated by articles that follow from seven of Centers for Excellence have been funded National Institutes Health (NIH) to Knowledge (BD2K) initiative. BD2K trans-NIH program, all and at NIH as well Common Fund; it overseen Office Science within Director. The beginnings described previously,1 purpose here provide an overall context, …
ASCO, through its wholly owned subsidiary, CancerLinQ LLC, developed CancerLinQ, a learning health system for oncology. A is important oncology patients because less than 5% of with cancer enroll in clinical trials, leaving evidence gaps patient populations not enrolled trials. In addition, trial often differ from the overall population respect to age, race, performance status, and other parameters.
Abstract Objectives Electronic health records (EHRs) contain a large quantity of machine-readable data. However, institutions choose different EHR vendors, and the same product may be implemented differently at sites. Our goal was to quantify interoperability real-world implementations with respect clinically relevant structured Materials Methods We analyzed de-identified aggregated data from 68 oncology sites that 1 5 vendor products. Using 6 medications laboratory tests for which...
Analogues of E. coli dihydrofolate reductase (DHFR) containing modified amino acids at single, predetermined sites have been prepared. This was accomplished by the use DHFR gene an engineered nonsense codon (TAG) positions corresponding to Val-10 and Asp-27. Misacylated suppressor tRNAs activated with interest were employed for suppression codons in a cell free protein biosynthesizing system, thereby permitting elaboration desired analogues. In this fashion, aspartic acid analogues...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecognition of tRNACys by Escherichia coli cysteinyl-tRNA synthetaseGeorge A. Komatsoulis and John AbelsonCite this: Biochemistry 1993, 32, 29, 7435–7444Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/bi00080a014https://doi.org/10.1021/bi00080a014research-articleACS PublicationsRequest reuse permissionsArticle Views234Altmetric-Citations41LEARN ABOUT...
A new computational method (chimeric alignment) has been developed to detect chimeric 16S rRNA artifacts generated during PCR amplification from mixed bacterial populations. In contrast other nearest-neighbor methods (e.g., CHECK_CHIMERA) that define sequence similarity by k-tuple matching, the alignment uses score dynamic programming alignments. Further, alignments are displayed user assist in classification. The distribution of improvement scores for 500 authentic, nonchimeric sequences...
Abstract Background The Cancer Biomedical Informatics Grid (caBIG™) is a network of individuals and institutions, creating world wide web cancer research. An important aspect this informatics effort the development consistent practices for data standards development, using multi-tier approach that facilitates semantic interoperability systems. tiers include (1) information models, (2) common elements, (3) controlled terminologies ontologies. College American Pathologists (CAP) protocols...
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CBFA) beta (CBFB), respectively. These represent two most common genomic abnormalities in acute myeloid leukemia (AML) patients, occurring approximately 25% pediatric 15% adult with this malignancy. Both are associated favorable clinical outcomes after intensive chemotherapy, given perceived mechanistic similarities, patients these frequently referred to as having CBF-AML. It remains uncertain...
PURPOSE: Cancer prevalence and outcomes data, necessary to understand disparities in transgender populations, are significantly hampered because gender identity data not routinely collected. A database of clinical on people with cancer, CancerLinQ, is operated by the ASCO collected from practices across United States multiple electronic health records. METHODS: To attempt identify cancer within we used three criteria: (1) International Classification Diseases 9/10 diagnosis (Dx) code...
110 Background: Anecdotal and early evidence suggest ICIs are being used in patients with advanced malignancies history of AD, despite such typically excluded from traditional clinical trials. We compared the outcomes or without all whom had ICI treatment for aNSCLC. Methods: conducted a retrospective, observational cohort study using de-identified, curated data ASCO’s CancerLinQ. Patients Stage III IV NSCLC who received ≥1 dose an ≥2 visits Jan 2011 to Nov 2018 were included. AD status...
LBA108 Background: Restrictive trial eligibility criteria limit data generalizability and patient opportunity to participate. We compared numbers characteristics of patients (pts) eligible using traditional vs expanded recommended by ASCO Friends Cancer Research. Methods: A retrospective, observational analysis used deidentified EHR from ASCO’s CancerLinQ database. Study cohort included adult aNSCLC pts with ≥2 visits ≥1 dose systemic treatment post-advanced-disease diagnosis 2011-2018....
To evaluate the completeness of information for research and quality assessment through a linkage between cancer registry data electronic health record (EHR) refined by ASCO's technology platform CancerLinQ.
Abstract caArray is an open-source, open development, web and programmatically accessible array data management system developed at National Cancer Institute. It was to support the exchange of across Biomedical Informatics Grid (caBIG™), a collaborative information network that connect scientists practitioners through shareable interoperable infrastructure share knowledge. adopts federated model local installations, in which deposited are caBIG™. Comprehensive annotation yet easy use has...
84 Background: Patients with cancer may face difficult care decisions during the COVID-19 outbreak in US. Understanding risk factors help patients and oncologists identify high-risk plan for best treatment a timely fashion. This analysis provides an assessment of racial ethnic disease within CancerLinQ (CLQ) Discovery database. Methods: CLQ is health technology platform developed by ASCO, which collects aggregates longitudinal electronic record (EHR) data from oncology practices throughout...
6583 Background: Although pts with AD are routinely excluded from ICI clinical trials, evidence suggests they may be receiving therapy once approved. We sought to understand the prevalence of among all ICIs in real world care, as well advanced non-small cell lung cancer (aNSCLC) alone, and describe characteristics without AD. Methods: conducted a retrospective, observational cohort study using statistically de-identified data January 2011 November 2018 CancerLinQ, ASCO’s real-world oncology...
e19318 Background: ECOG PS is a prognostic indicator of outcomes, and scores 0-1 (good PS) are often required for clinical trial enrollment. Patients treated in non-trial settings lack limiting the ability Real World Data from these patients to be used external control arms (ECAs) or provide optimal specificity effectiveness research. Machine Learning can impute other data at various points during treatment. Methods: We developed series models using logistic regression (LR) XGBoost (XGB)...
e18317 Background: The National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) Program curates population-based cancer data representing 34% of the US population. CancerLinQ is an ASCO initiative that collects analyzes electronic health record (EHR) to give oncologists opportunities improve quality patient care. With shared goal understanding care delivery, NCI SEER launched a pilot linkage. Purpose: Establish exchange between registries oncology practices a)...
Article Free Access Share on Chimeric alignment by dynamic programming: algorithm and biological uses Authors: George A. Komatsoulis Departments of Mathematics, The University Southern California, Los Angeles, CA CAView Profile , Michael S. Waterman Mathematics Biological Sciences, Authors Info & Claims RECOMB '97: Proceedings the first annual international conference Computational molecular biologyJanuary 1997Pages 174–180https://doi.org/10.1145/267521.267546Published:19 January...
5583 Background: Tumors with homologous recombination repair deficiencies (HRD+) are susceptible to PARP inhibitors (PARPi) which exploit a synthetic lethality by targeting an essential base excision (BER) pathway. Current biomarkers designed predict efficacy of PARPi (BRCA1/2 mut , HRD+) ineffective, particularly in advanced stages therapy.There is urgent unmet need for improved that acute patients who fail multiple lines therapy. We sought develop and validate predictive signature...