A5016054629- Obesity, Physical Activity, Diet
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Breastfeeding Practices and Influences
- Immune Cell Function and Interaction
- Bioinformatics and Genomic Networks
- Eating Disorders and Behaviors
- Cancer, Lipids, and Metabolism
- AI in cancer detection
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolomics and Mass Spectrometry Studies
- Renal Transplantation Outcomes and Treatments
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Microtubule and mitosis dynamics
- Neuroblastoma Research and Treatments
- Recommender Systems and Techniques
Spanish National Cancer Research Centre
2020-2025
Centro de Investigación Biomédica en Red de Cáncer
2023-2025
Cancer Research Center
2024
Centro de Investigación del Cáncer
2022-2024
Complejo Hospitalario Universitario de Santiago
2022
Centro Nacional de Epidemiología
2022
Centro Nacional de Investigaciones Científicas
2022
Instituto Tecnológico de Aragón
2020
Summary Background Although the genetic interplay with environment has a major impact on obesity development, little is known whether breastfeeding could modulate predisposition to obesity. Objectives To investigate attenuates effect of an risk score (GRS) adiposity in European adolescents. Methods Totally 751 adolescents from Healthy Lifestyle Europe by Nutrition Adolescence (HELENA) cross‐sectional study were included, divided according status into never breastfed, 1–3 months and ≥4...
Graphical Abstract
Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge, with five-year survival rate of approximately 10%. Tumor heterogeneity contributes to the limited effectiveness treatments. Several tumor and stroma molecular classifiers have attempted clarify this moderate agreement. Recognizing complexity introduced by extensive array taxonomies, study aims develop consensus classifier including both features. We integrated gene expression data through Virtual Microdissection...
Abstract Studies reported that atopic individuals exhibit a 36% reduced risk of developing pancreatic ductal adenocarcinoma (PDAC); however, the underlying molecular mechanisms remain unclear. This study examines specific role type‐2 immune response in atopy–PDAC inverse association. To endotype conditions using effectors (i.e., eosinophils and immunoglobulin‐E[IgE]) investigate their protective effect against PDAC risk, IgE levels were measured 688 cases 558 controls from PanGenEU...
Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine predisposition obesity. Therefore, aim our study was build GRS able predict overweight obesity European adolescents. A total 1069 adolescents (51.3% female), aged 11-19 years participating Healthy Lifestyle Europe by Nutrition Adolescence (HELENA) cross-sectional were genotyped. The sample...
Pancreatic ductal adenocarcinoma (PDAC) is often treated with FOLFIRINOX, a chemotherapy associated high toxicity rates and variable efficacy. Therefore, it crucial to identify patients at risk of early progression during treatment. This study aims explore the potential multi-omics biomarker for predicting PDAC by employing an in-depth mathematical modeling approach. Blood samples were collected from 58 undergoing FOLFIRINOX before after first cycle. These underwent gene (GEP) inflammatory...
Abstract Early-life onset of high blood pressure is associated with the development cardiovascular diseases in adulthood. In adolescents, limited evidence exists regarding association between adherence to Mediterranean Diet (MedDiet) and normal (BP) levels, as well its potential modulate genetic predisposition HTN. This study investigated interaction a MedDiet score recently developed HTN-genetic risk (HTN-GRS) on levels European adolescent cohort. The was derived from two non-consecutive...
Childhood obesity is a worldwide epidemic. Mediterranean diet (MD) inversely associated with childhood obesity, but the interaction other environmental factors, such screen time, might influence health benefits of high MD adherence in adolescents. The aim present study was to assess whether an association between and time exists European Moreover, we also explored sedentary has modulatory effect on adiposity. Adherence (24 h recalls), (questionnaire), pubertal development, body mass index...
Abstract Precision oncology research is challenging outside the contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics a powerful approach to reveal patient subsets interest characterized by activity few kinases where underlying genomics complex. Here, we conduct phosphoproteomic screening samples from HER2-negative female breast cancer receiving neoadjuvant paclitaxel ( N = 130), aiming find candidate biomarkers sensitivity. Filtering 11...
Obesity and metabolic syndrome (MetS) are worldwide major health challenges. The Mediterranean diet (MD) is associated with a better cardiometabolic profile, but these beneficial effects may be influenced by genetic variations, modulating the predisposition to obesity or MetS. aim was assess whether interaction occur between an risk score (obesity-GRS) MD on adiposity MetS in European adolescents. Multiple linear regression models were used of obesity-GRS its components. Interaction observed...
ABSTRACT Genetic susceptibility loci are associated with PDAC risk and survival, but the impact of germline HLA region variation remains largely unexplored. This study examined I-II alleles within PanGenEU validated our findings using external datasets (UK Biobank, TCGA, PAN-NGS trial, Caris trial). HLA-A*02:01and HLA-B*49 were linked to a decreased PDAC, whereas HLA-B*39 , HLA-DPB1*04, HLA-A*26:01 directly increased risk. patients carrying HLA-A*02:01 allele also showed lower mortality...
From genome wide association study (GWAS) a large number of single nucleotide polymorphisms (SNPs) have previously been associated with blood pressure (BP) levels. A combination SNPs, forming genetic risk score (GRS) could be considered as useful tool to identify individuals at developing hypertension from early stages in life. Therefore, the aim our was build GRS being able predict predisposition (HTN) European adolescents.Data were extracted Healthy Lifestyle Europe by Nutrition...
Content-Based Recommendation Systems suggest items (e.g., articles, products, objects, services, or places) that are relevant to the user based on features describing items. In many content-based recommendation systems we can find, along with discrete attributes, textual text summaries comments) obtained from web pages, news etc. Traditionally, enable its exploitation, information of is represented by using basic retrieval models (such as vector space model), which do not take into account...
Abstract The nucleosome remodeling factor BPTF is required for the deployment of MYC-driven transcriptional program. Deletion one Bptf allele delays tumor progression in mouse models pancreatic cancer and lymphoma. In neuroblastoma, MYCN cooperates with core regulatory circuitry (CRC). High levels are associated high-risk features decreased survival. depletion results a dramatic decrease cell proliferation. Bulk RNA-seq, single-cell sequencing, tissue microarrays reveal positive correlation...
Abstract Background Hepatic disorders are often complex and multifactorial, modulated by genetic environmental determinants. During the last years, hepatic disease has been progressively established from early stages in life. The use of risk scores (GRS) to predict susceptibility a particular phenotype among youth gained interest recent years. Moreover, alanine aminotransferase (ALT) blood biomarker is considered as screening tool, combination with imaging techniques. aim present study was...