A5023067254- Neuroscience and Neural Engineering
- Anatomy and Medical Technology
- Vagus Nerve Stimulation Research
- Surgical Simulation and Training
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Reconstructive Surgery and Microvascular Techniques
- Lymphatic System and Diseases
- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Organ Transplantation Techniques and Outcomes
- Prosthetics and Rehabilitation Robotics
- Sympathectomy and Hyperhidrosis Treatments
- Botulinum Toxin and Related Neurological Disorders
- Electrospun Nanofibers in Biomedical Applications
- Molecular Sensors and Ion Detection
- Diversity and Career in Medicine
- Renal Transplantation Outcomes and Treatments
- Organ and Tissue Transplantation Research
- Liver physiology and pathology
- Tissue Engineering and Regenerative Medicine
- Digital Imaging in Medicine
- Neurological disorders and treatments
- Transplantation: Methods and Outcomes
- Orthopedic Surgery and Rehabilitation
University of Wisconsin–Madison
2018-2025
Huazhong University of Science and Technology
2023-2025
Tongji Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Ministry of Education of the People's Republic of China
2024-2025
Academy of Medical Sciences
2025
Southern Taiwan University of Science and Technology
2025
Central South University
2024
Creative Commons
2020-2023
Guangzhou Medical University
2015-2022
Given current clinical interest in vagus nerve stimulation (VNS), there are surprisingly few studies characterizing the anatomy of large animal models as it pertains to on-and off-target engagement local fibers. We sought address this gap by evaluating vagal pig, whose organization and size approximates human nerve.
Implanted neural stimulation and recording devices hold vast potential to treat a variety of neurological conditions, but the invasiveness, complexity, cost implantation procedure greatly reduce access an otherwise promising therapeutic approach. To address this need, novel electrode that begins as uncured, flowable prepolymer can be injected around neuroanatomical target minimize surgical manipulation is developed. Referred Injectrode, conforms structures forming electrically conductive...
Xie, Qingping; Louveau, Antoine; Pandey, Sonia; Zeng, Weifeng; Chen, Wei F. Author Information
Background and Aims: HCC is a highly heterogeneous disease that caused largely by genomic copy number variations. Herein, the mechanistic therapeutically targeted role of vacuolar protein sorting 72 homologue (VPS72), novel variation cis-driven gained gene identified genome-wide transcriptome analyses in HCC, not well understood. Approach Results: First, overexpression VPS72 enhanced initiation progression vitro vivo . Mechanistically, interacted with oncoproteins MYC actin-like 6A (ACTL6A)...
IntroductionVagus nerve stimulation (VNS) is an FDA-approved neuromodulatory treatment used in the clinic today for epilepsy, depression, and cluster headaches. Moreover, evidence literature has led to a growing list of possible clinical indications, with several small trials applying VNS treat conditions ranging from neurodegenerative diseases arthritis, anxiety disorders, obesity. Despite therapeutic applications, fundamental mechanisms by which achieves its beneficial effects are poorly...
PtRu alloys have been recognized as the state-of-the-art catalysts for methanol oxidation reaction (MOR) in direct fuel cells (DMFCs). However, their applications DMFCs are still less efficient terms of both catalytic activity and durability. Rare earth (RE) metals attractive elements to tune activity, while it is a world-class challenge synthesize well-dispersed Pt-RE alloys. Herein, we developed novel hydrogen-assisted magnesiothermic reduction strategy prepare highly dispersed...
Abstract Background High levels of precision, as well controlled, efficient motions, are important components microsurgical technique and success. An accurate objective means skill assessment is lacking in resident education. Here we employ three-dimensional, real-time motion-tracking technology to analyze hand instrument motion during anastomoses. We hypothesize that metrics can objectively quantify predict the overall level expertise. Methods Seventeen participants including medical...
Introduction: Peripheral nerve reinnervation following injury is often a slow and incomplete process, resulting in significant morbidity permanent loss of function the injured extremity many patients. Prior studies have shown efficacy electrical stimulation to synchronize axonal regeneration both motor sensory neurons peripheral models. Moreover, separate investigations also use cranial stimulation, principally vagus nerve, improve functional outcomes. However, no study has investigated...
Highlights•A 3-mm-diameter graft is developed using PSC-derived arterial endothelial cells•MHC-WT grafts maintain 100% patency for 6 months in an allogeneic rhesus model•The endothelium repopulated with host cells, ensuring the long-term patencySummaryAutologous vascular grafts, only clinically approved option small-diameter (<6 mm) revascularizations, require invasive harvesting and have limited availability variable quality. To address these challenges, we develop a artery by cells (AECs)...
Hepatocellular carcinoma (HCC) with MYC oncogene amplification remains a serious challenge in clinical practice. Recent advances comprehensive treatment strategies, particularly the combination of radiotherapy and immunotherapy, offer new hope. To further improve efficacy while lowering radiation doses, nanopharmaceuticals based on high-Z elements have been extensively studied radio-immunotherapy. In this work, hafnium-based metal-organic framework (Hf-MOF), UiO-66-Hf(2OH)-CB-839/BSO@HA...
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A highly sensitive fluorescent probe (1) based on styrylcyanine dye for Cu2+ and Pb2+ has been developed. Probe 1 exhibited turn-off sensing ability to Cu2+. On the other hand, displayed ratiometric response towards with a distinct color change from blue orange. The 1H NMR titrations revealed that of is triggered by interaction pyridine unit metal ion. Detection limits or were calculated as 1.24 3.41 × 10−6 M, respectively, standard deviation linear fitting. Furthermore, can also be used...
This study investigated the beneficial effect of lycopene on bone biomarkers in ovariectomized (OVX) rats. Female Wistar rats were either sham operated or surgically and then fed with for 8 weeks. Serum Ca, P, alkaline phosphatase (ALP), interleukin 6 (IL-6) gla protein (BGP) concentration was significantly higher untreated OVX group compared that group, whereas serum estrogen levels lower. Bone mineral density (BMD), BMD/wt, content (BMC), BMC/wt values, maximum load, stiffness, energy...
Tuftelin 1 (TUFT1), a protein functioning distinctively in different tissues, is reported to be elevated several types of cancers and the elevation TUFT1 correlated with unfavorable clinicopathologic characteristics poor survival. However, involvement renal cell carcinoma (RCC) remains unknown. In current study, we investigated role RCC potential underlying mechanisms. RT-PCR Western blot analysis showed that both mRNA levels were increased primary tissue lines. overexpression cells resulted...
Transmembrane 4 L six family member 1 (TM4SF1) is highly expressed in and contributes to the progression of various malignancies. However, how it modulates hepatocellular carcinoma (HCC) senescence remains be elucidated.
Liposuction is the treatment of choice for solid predominant extremity lymphedema. The classic lymphedema liposuction technique does not remove skin excess created following bulk removal. presumed to resolve with spontaneous contracture. We investigated simultaneously performing immediate excision in patients and compared outcome that from technique.Modified (mLIPO) standard without (sLIPO) were offered Skin traction 4 cm undulating mobility constituted positive "flying squirrel" sign....
Abstract Background The high level of technical skill required by microsurgical procedures has prompted the development in vitro educational models. Current models are cost-ineffective, unrealistic, or carry ethical implications and utilized as isolated experiences within single surgical specialties. purpose this study was to assess interprofessional effect a training course utilizing nonliving “Blue-Blood” chicken thigh model (BBCTM) multidisciplinary environment. Methods A 10-hour...
Abstract Background Vagus nerve stimulation (VNS) is a FDA approved therapy regularly used to treat variety of neurological disorders that impact the central nervous system (CNS) including epilepsy and stroke. Putatively, therapeutic efficacy VNS results from its action on neuromodulatory centers via projections vagus solitary tract nucleus. Currently, there not an established large animal model facilitates detailed mechanistic studies exploring how impacts function CNS, especially during...