A5016057763- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Pluripotent Stem Cells Research
- Atherosclerosis and Cardiovascular Diseases
- Sphingolipid Metabolism and Signaling
- Respiratory Support and Mechanisms
- Cholesterol and Lipid Metabolism
- Cancer Cells and Metastasis
- Neuroscience of respiration and sleep
- Cellular Mechanics and Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Cytokine Signaling Pathways and Interactions
- 3D Printing in Biomedical Research
Chiesi (Italy)
2022-2025
University of Parma
2019-2024
Chiesi (France)
2023-2024
Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. However, the toxicity strong hyperoxic hit precludes longer-term follow-up due high mortality after first week life. This study aimed extend preterm postnatal day (PND) 14 mimic evolving phase and enable investigation therapeutic interventions at later more relevant...
3D embryonic stem cell (ESC) aggregates self-organize into embryo-like structures named gastruloids that recapitulate the axial organization of post-implantation embryos. Crucial in this process is symmetry-breaking event leads to emergence asymmetry and spatially ordered from homogeneous aggregates. Here, we show budesonide, a glucocorticoid drug widely used treat asthma, prevents ESC break symmetry. Mechanistically, effect budesonide receptor independent. RNA sequencing lineage fate...
Small molecules that can modulate or stabilize cell–cell interactions are valuable tools for investigating the impact of collective cell behavior on various biological processes such as development/morphogenesis, tissue regeneration and cancer progression. Recently, we showed budesonide, a glucocorticoid widely used an anti-asthmatic drug, is potent regulator stem pluripotency. Here tested effect different budesonide derivatives identified CHD-030498 more effective analogue budesonide. was...
Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia. However, the pulmonary outcomes postnatal TZDs not investigated preterm animal models. Here, we first selectivity, epithelial permeability, and lung tissue binding three types vitro (rosiglitazone (RGZ), pioglitazone, DRF-2546), followed by an vivo study rabbits exposed (95% oxygen) investigate...
<title>Abstract</title> Background Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing purposes. However, the toxicity strong hyperoxic “hit” precludes longer-term follow-up due high mortality after first week life. This study aimed extend preterm postnatal day (PND) 14 mimic evolving phase and investigate therapeutic...
Sphingosine 1-phosphate (S1P) is a lysosphingolipid with anti-atherogenic properties, but mechanisms underlying its effects remain unclear. We here investigated atherosclerosis development in cholesterol-rich diet-fed LDL receptor-deficient mice high or low overexpression levels of S1P receptor type 1 (S1P1) macrophages. S1P1-overexpressing macrophages showed increased activity transcription factors PU.1, IRF8, and LXR were skewed towards M2-distinct phenotype characterized by enhanced...
Small molecules that can modulate or stabilize cell-cell interactions are valuable tools for investigating the impact of collective cell behavior on various biological processes such as development/morphogenesis, tissue regeneration and cancer progression. Recently, we showed budesonide, a glucocorticoid widely used anti-asthmatic drug, is potent regulator stem pluripotency. Here tested effect different budesonide derivatives identified CHD-030498 more effective analogue budesonide. was able...
Preterm birth alters normal lung development, leading to bronchopulmonary dysplasia (BPD). rabbit is being recognized as a relevant BPD model, but deeper molecular characterization needed. The aim was characterize premature and postnatal oxygen impact on pathways. pups delivered at 28 days of gestation were randomly assigned hyperoxia (HOX 70% O2, n=12) or room-air (RA, 21% n=27) for 14 days. Lungs harvested 1, 3, 5, 7, 9, 11, 14. Age-matched term used controls (n=27). Radial alveolar count...