A5052256530- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Blood groups and transfusion
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- COVID-19 impact on air quality
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Selenium in Biological Systems
- COVID-19 epidemiological studies
- Circular RNAs in diseases
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Erythrocyte Function and Pathophysiology
- CNS Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Blood transfusion and management
Xuzhou Central Hospital
2024-2025
Guilin Medical University
2025
Northwestern Polytechnical University
2025
Second Hospital of Shandong University
2025
South China University of Technology
2018-2024
Guangzhou Medical University
2013-2022
Guangzhou First People's Hospital
2013-2022
First Affiliated Hospital of Jinan University
2018
Nanjing Chest Hospital
2015
NOSM University
2013
The drug-resistance and relapse of diffuse large B-cell lymphoma (DLBCL), which are related to mesenchymal stem cells (MSCs), have become increasingly common. However, the underlying mechanisms remain elusive. CCK 8 assay, colony formation xenograft mouse model were used investigate effects hBMSCs on DLBCL growth. Immunohistochemistry, qRT-PCR, ELISA study expressions IL-6 IL-17A. Flow cytometry was analyze Th17 Treg expressions. Western blot analysis, microarray bioinformatics analysis...
Background Currently, the computed tomography (CT) radiomics-based models, which can evaluate small (≤ 20 mm) solid pulmonary nodules (SPNs) are lacking. This study aimed to develop a CT model that differentiate between benign and malignant SPNs. Methods included patients with SPNs January 2019 November 2021. The participants were then randomly categorized into training testing cohorts an 8:2 ratio. images of all analyzed extract radiomics features. Furthermore, scoring was developed based...
This study compares the population and repair ability of bone marrow hematopoietic stem cells (HSCs) mesenchymal (MSCs) in experimental colitis (EC) rat model after allogeneic stem-cell transplantation (SCT).EC was induced by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS). The HSCs, MSCs, HSCs+MSCs, derived from male Sprague-Dawley rats, were cultured labeled with bromodeoxyuridine then transplanted into EC rat. colon samples collected for histologic evaluation at days 7, 14, 21...
Abstract Introduction The purpose of this study was to investigate the expression Wnt and Notch signaling pathway-related genes in inflammatory bowel disease (IBD) treated with mesenchymal stem cell transplantation (MSCT). Methods TNBS (2,4,6-trinitrobenzene sulfonic acid) used establish IBD a rat model. Mesenchymal cells (MSCs) were transplanted via tail vein transfusion. Saline water control group. main molecules screened by gene chips verified quantitative reverse transcription-polymerase...
There remains a great need for effective therapies cervical cancers, the majority of which are aggressive leaving patients with poor prognosis.Here, we identify novel candidate therapeutic target, trefoil factor 3 (TFF3) overexpressed in cancer cells and was associated reduced postoperative survival. Functional studies demonstrated that TFF3 overexpression promoted proliferation invasion cells, inhibited apoptosis by inducing mRNA changes SiHa Hela cell lines. Conversely, silencing disrupted...
Screening of natural products with anti-tumor activity as telomerase inhibitor is a new subject in the field tumor therapy. Using PCR ELISA, telomere DNA hybridization and flow cytometry analysis, effects verbascoside, phenylpropanoid glucoside extracted from Pedicularis striata Pall, on activity, length cell cycle human gastric carcinoma cells MKN45 was examined vitro. After being treated 50 % inhibition concentration verbascoside (17.8 μg/ml), significantly inhibited but not cellular...
Rituximab resistance has become increasingly common in patients with diffuse large B cell lymphoma (DLBCL). However, the mechanisms involved remain unclear. In this study, we aimed to examine effect of rituximab on interleukin (IL)-17A and investigate role IL-17A its prognostic value DLBCL. Our retrospective analysis revealed that increased IL-6 expression levels DLBCL, turn induced differentiation Th17 IL-17+Foxp3+ Treg cells, which secreted both vivo vitro. We then examined effects...
COVID-19 is a global pandemic. The purpose of this study to explore correlations between the novel coronavirus (COVID-19) and meteorological indicators from cities across China.
Previous studies have demonstrated that microRNAs (miRNAs/miRs) act as tumor suppressors or oncogenes during multiple processes in cancer. It has been observed miR‑27b may a tumor‑suppressor and was significantly downregulated number of types However, the functions gastric cancer (GC) remain unclear. The present study aimed to investigate functional role progression GC. downregulation human GC plasma confirmed using miRNA microarray reverse transcription‑quantitative polymerase chain...
BACKGROUND The aim of this study was to estimate the number blood donors during COVID‐19 incubation period across China. STUDY DESIGN AND METHODS In study, we developed a predictive model among 34 provincial regions in Our main assumption that all ages different have stable donation intention and same infection risk. RESULTS First, estimated Wuhan city, Hubei Province, China, from December 31, 2019 March 17, 2020. Second, compared provinces addition, found if RBCs, plasma, cryoprecipitation...
<b>Introduction: </b>Stored red blood cells (RBCs) undergo storage lesions involving morphological, physiological and biochemical changes. MicroRNAs (miRNAs) have important functions in cell apoptosis life processes. Therefore, the aim of this study was to explore potential roles miRNAs damage stored RBCs. <b>Methods: </b>Blood samples were collected from 13 healthy male O-type donors, leuko-reduced RBCs divided into fresh RBC group 20-day group. <b>Results:...
Neonatal alloimmune thrombocytopenia (NAIT), caused by maternal antibodies raised against alloantigens carried on foetal platelets, is a very common haematological abnormality in newborns worldwide. However, baseline data NAIT China are lacking. Therefore, this study seeks to explore the incidence of alloantibody human platelet antigen (HPA) pregnant women and its associations with China. A multicentre, prospective cohort design will be used, 55,497 recruited for first screening anti-HPA...
HLA ‐B*13:01:06 has one nucleotide acid change (G→A) at position 219, codon 49 ( GCG → GCA ) in exon2 without amino (Ala→Ala).