A5035868203- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Patient Dignity and Privacy
- Healthcare cost, quality, practices
- Grief, Bereavement, and Mental Health
- Cancer Treatment and Pharmacology
- Family and Patient Care in Intensive Care Units
- Pharmaceutical studies and practices
- Clinical Reasoning and Diagnostic Skills
- Innovations in Medical Education
- Bone health and treatments
- Childhood Cancer Survivors' Quality of Life
- Healthcare Decision-Making and Restraints
- Medical Imaging and Pathology Studies
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Health, Medicine and Society
- Medication Adherence and Compliance
- Delphi Technique in Research
- Venous Thromboembolism Diagnosis and Management
- Geriatric Care and Nursing Homes
- Erythropoietin and Anemia Treatment
- Clinical practice guidelines implementation
Erasmus MC Cancer Institute
2016-2025
Erasmus MC
2014-2024
Erasmus University Rotterdam
2013-2021
Reinier de Graaf Hospital
2018
American Geriatrics Society
2017
Dokuz Eylül University
2015
Medisch Centrum Alkmaar
2012
Amsterdam UMC Location Vrije Universiteit Amsterdam
2008-2012
Percentage of patients who achieve a response, including complete response (complete disappearance lesions) or partial (reduction in the sum maximal tumour diameters by ≥30%).Many hormonal and chemotherapies may also stabilise an advanced cancer, which be great importance for order to increase life expectancy.
The rational prescribing of drugs is an essential skill medical doctors. Clinical pharmacologists play important role in the development these skills by teaching clinical pharmacology and therapeutics (CP&T) to undergraduate students. Although approaches CP&T have undergone many changes over last decennia, it that actual continues be a major part curriculum.The learning objectives terms developing therapeutic competencies students are described, with emphasis on decision-making. On basis...
<h3>Importance</h3> <i>Death rattle</i>, defined as noisy breathing caused by the presence of mucus in respiratory tract, is relatively common among dying patients. Although clinical guidelines recommend anticholinergic drugs to reduce death rattle after nonpharmacological measures fail, evidence regarding their efficacy lacking. Given that anticholinergics only decrease production, it unknown whether prophylactic application may be more appropriate. <h3>Objective</h3> To determine...
Background: Data on risks and benefits of long-term anticoagulants in patients with a life-limiting disease are limited. This cohort study aims to describe (dis)continuation incidences bleeding thromboembolic events vitamin K antagonist (VKA) users disease. Methods: from five Dutch anticoagulation clinics were linked data Statistics Netherlands the Cancer registry. Prevalent VKA diagnosed pre-specified between 01/01/2013 31/12/2019 included followed until 31/12/2019. Hospitalization used...
In Brief BACKGROUND: Cisplatin is considered safe to use during the second and third trimesters of pregnancy in patients with cancer. CASE: A 34-year-old pregnant woman was diagnosed cervical She received five weekly dosages cisplatin paclitaxel, starting at 26 5/7 weeks gestation. An elective cesarean delivery performed 34 4/7 After birth, neonate severe bilateral perceptive hearing loss. CONCLUSION: may lead fetal ototoxicity. cause
The purpose of medication management in the last days life is to optimize patient's comfort. Little known about use before death and how this relates care setting.To describe week for patients dying hospital, hospice, home settings Netherlands.Retrospective chart review study.A convenience sample patient records from three different regions Netherlands that cover more than half country.Information who ultimately died an expected was registered, including type medication, start if applicable...
Even though antithrombotic therapy has probably little or even negative effects on the well-being of people with cancer during their last year life, deprescribing at end life is rare in practice. It often continued until death, possibly resulting excess bleeding, an increased disease burden and higher healthcare costs.The SERENITY consortium comprises researchers clinicians from eight European countries specialties different clinical fields, epidemiology psychology. will use a comprehensive...
Abstract Background The integral model of Palliative Care recognizes the community as essential element in improving quality life patients and families. It is necessary to find a formula that allows have voice. aim this scoping review identify barriers facilitators engage PC. Methods Systematic search was conducted NICE, Cochrane Library, Health Evidence, CINAHL PubMed database. Keywords: care, End networks, engagement, public participation, social facilitators. Results Nine hundred...
Rationale Extensive research has been conducted on clinical reasoning to gain better understanding of this process. Clinical defined as the process thinking critically about diagnosis and patient management. However, most focused diagnostic reasoning. Because lack regarding therapeutic reasoning, education in management decisions lacks a solid theoretical basis. Aims objective To improve medical education, training refresher courses with regard decision making. Methods A search literature...
ABSTRACT Objective: Our aim was to gain insight into the perspectives of patients, close relatives, nurses, and physicians on medication management for patients with a life expectancy less than 3 months. Method: We conducted an empirical multicenter study qualitative approach, including in-depth interviews specialists, general practitioners (GPs). used constant comparative method ATLAS.ti (v. 7.1) software our analysis. Results: Saturation occurred after 18 patient cases (76 interviews)....
Abstract Background Patients in the last phase of their lives often use many medications. Physicians tend to lack awareness that reviewing usefulness medication at end patients’ is important. The aim this study gain insight into perspectives patients, informal caregivers, nurses and physicians on role management life. Methods Semi-structured interviews were conducted with patients lives, hospitals, hospices home; physicians. Data qualitatively analyzed using constant comparative method....
Introduction Adequately addressing the needs of patients at end life and their relatives is pivotal in preventing unnecessary suffering optimising quality life. The purpose iLIVE study to contribute high-quality personalised care different countries cultures, by investigating experiences, concerns, preferences use terminally ill families. Methods analysis an international cohort which with estimated expectancy 6 months or less are followed up until they die. In total, 2200 will be included...
Antithrombotics are frequently prescribed for patients with a limited life expectancy. In the last phase of life, when treatment is primarily focused on optimizing patients' quality use antithrombotics should be reconsidered.
Many patients who are in the last phase of life use multiple medications that continued until shortly before they ultimately die. Little is known about physicians' opinions and experiences regarding medication discontinuation at end patients' lives.To explore during life, to identify factors influencing continuation potentially inappropriate medications.Questionnaire study, including a vignette several statements.A random sample general practitioners clinical specialists working three...
For people with limited lifetime expectancy, the benefit of many medications may be outweighed by their potential harms. Despite relevance reducing unnecessary medication use, deprescribing is poorly enacted in primary care practice.
Capecitabine has activity against several types of cancer. In 10-15% patients treated with capecitabine, treatment is discontinued because serious adverse reactions, mostly within the first weeks treatment.A 56 year-old female patient presented at emergency department after ten days chemotherapy progressive airway obstruction and complaints numbness tongue. She also had difficulty swallowing was unable to speak. Laboratory findings were completely normal no co-medication used, in particular...
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This study aims to determine the feasibility of incorporating structured therapeutic consultations (TCs) into clinical clerkship internal medicine. TCs were considered feasible if students able draw up a plan and carry out TC, their supervisors workable useful. From March 2008 October 2009, medical carried "diagnostic" subsequent "therapeutic" consultation with same patient during medicine at VU University Medical Center. After diagnosis was established, student had formulate then TC...
Patients with a limited life expectancy use many medications, some of which may be questionable. Objectives To identify possible solutions for difficulties concerning medication management and formulate recommendations to improve at the end life. Methods A two-round Delphi study experts in field end-of-life care (based on ranking citation index Web Science relevant publications). We developed questionnaire 58 problems regarding that were identified previously performed studies. Results total...