BACKGROUNDSoluble HLA-G (sHLA-G) has been suggested as a non-invasive marker for embryo selection to improve pregnancy rates after assisted reproduction technique (ART). Our study aimed at the identification of parameters influencing detection sHLA-G in cultures (ECs) and prognostic relevance multi-centre study.

The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study broiler turkeys. All the fenicol antibiotics were administered at a dose 30 mg/kg b.w. their concentrations plasma samples assayed using same validated high‐performance liquid chromatography method. Pharmacokinetic parameters calculated by noncompartmental kinetic profiles compounds compared with...

Florfenicol is a broad-spectrum bacteriostatic antibiotic used in domestic animals. The aim of the study was to determine effect florfenicol on total number lymphocytes thymus, spleen and mesenteric lymph nodes percentage absolute T cell subsets (CD4+CD8+, CD4-CD8-, CD4+, CD8+) thymus (CD3+, B (CD19+) peripheral lymphatic organs non-immunized mice humoral immune response sheep red blood cells (SRBC)-immunized mice. administered orally at dose 30 mg/kg six times 24 h intervals four or seven...

Whereas interspecies variation in pharmacokinetics is a commonly investigated issue, variations drug kinetics within species are less documented. The aim of the study was to assess influence age-related changes haemodynamics on metronidazole (MTZ) and its hydroxy metabolite (MTZ-OH) turkeys. MTZ administered intravenously orally at dose 25 mg/kg. Plasma concentrations were assessed by high-performance liquid chromatography, pharmacokinetic parameters calculated noncompartmental analysis....

The pharmacokinetics of florfenicol (FF) and thiamphenicol (TP) after single intravenous (IV) oral (PO) administration was investigated in Mulard ducks. Both antibiotics were administered at a dose 30 mg/kg body weight, their concentrations plasma samples assayed using high-performance liquid chromatography with ultraviolet detection. Pharmacokinetic parameters calculated noncompartmental method. After IV administration, significant differences found for the mean residence time (2.25 ± 0.21...

Florfenicol is a broad-spectrum antibacterial drug used in the treatment of farm animals, including poultry. This poorly soluble water, therefore, administration drinking water may lead to high variability concentrations treated individuals. The use injection preparations, however, requires individual and have negative effect on quality carcass. In addition, renal portal system birds reduce bioavailability administered caudofemoral region body. aim this study was compare pharmacokinetics...

1. The aim of this study was to determine if the pharmacokinetics (PK) florfenicol (FF) undergo age-dependent changes in broilers. Since drug elimination depends on cardiovascular functions, a haemodynamic performed parallel. 2. Broilers 0.68, 1.27, 2.45 and 5.13 kg were administered FF single intravenous dose 30 mg/kg body weight. Plasma concentrations determined using high-performance liquid chromatography PK parameters calculated non-compartmental model. Echocardiography used measure...

1. This study evaluated the pharmacokinetic profiles of florfenicol (FF) and thiamphenicol (TP), which are synthetic bacteriostatic antimicrobial drugs, in geese after a single intravenous or oral administration, as well seven doses administered at 12 h intervals. For all treatments, dose was 30 mg/kg.2. After IV clearance volume distribution were low (0.23 ± 0.03 l/h/kg 0.57 0.08 l/kg for FF, 0.23 0.04 0.59 TP, respectively). The elimination half-life similar between products short (2.91...

Lasalocid sodium is a polyether carboxylic ionophore agent authorized by the EU for use as coccidiostat in broilers, turkeys, and pullets up to 16 weeks of age, except laying hens. However, hens are most common nontarget species exposed lasalocid sodium, mainly due cross-contamination from feed mills. This exposure may result potential drug residue deposition eggs, which could potentially expose consumers drug. The breeds commonly used commercial egg production Poland Isa Brown Green-legged...

1. Pharmacokinetics of acetylsalicylic acid (ASA) and sodium salicylate (SS) were assessed following single intravenous (i.v.) oral administration at doses 50 mg/kg body weight to chickens turkeys. Plasma drug concentrations determined using high-performance liquid chromatography with ultraviolet detection pharmacokinetic variables calculated a non-compartmental model. 2. The mean residence time (MRT) (SA) after i.v. SS was 6.08 ± 0.59 3.32 0.27 h 6.95 0.72 4.55 0.71 in turkeys,...

1. Effect of an herb extract mixture on growth performance, nutrient digestibility, blood characteristics, and fecal microbial shedding in weanling pigs L. Yan, Q.W. Meng, I.H. Kim Livestock Science CrossRef

1. Acetylsalicylic acid (ASA) and sodium salicylate (SS) are considered safe for poultry often used in avian medicine. However, information on tolerance specific side effects of these drugs birds is lacking. 2. The aim this study was to determine the 14 d administration high doses (200 or 400 mg/kg) either ASA SS body weight gain, blood biochemistry, white red cell counts pathology broilers. In addition, minimal plasma concentrations were determined 1st, 5th, 10th 14th treatment. 3. results...

Abstract Enrofloxacin is a concentration‐dependent antimicrobial used in bacterial infections poultry. During few months of turkey's life, pharmacokinetics drugs undergoes substantial changes which may compromise their efficacy due to variability internal exposure (measured by area under the concentration–time curve, AUC). The aim this study was describe effects age on single intravenous (i.v.) and oral administration enrofloxacin at dose 10 mg/kg turkeys. It found that during 2.5‐month‐long...

The aim of the study was to investigate effects different doses acetylsalicylic acid (ASA) and sodium salicylate (SS) administration on weight gains serum biochemical parameters in broiler chickens. This performed safety ASA SS chickens conditions moderate overdose. Seventy five (Sanhuangji breed) were divided into control experimental groups. administered orally with or following daily doses: 50, 100 200 mg/kg for 20 days. In course experiment recorded. On day 14 sampled blood analysis....

1. This experiment aimed to determine if the pharmacokinetics of amoxicillin (AMO) was affected by rapid growth or intravenous (i.v.) injection Escherichia coli lipopolysaccharide (LPS).2. Turkeys 2.0, 5.5 and 12.0 kg were administered i.v. orally with AMO sodium at dose 15 mg/kg. Another group (5.7 kg) treated LPS prior administration. Plasma drug concentrations determined using high-performance liquid chromatography pharmacokinetic parameters calculated a non-compartmental model. To assess...

Salicylates were the first non-steroid anti-inflammatory drugs (NSAIDs) to be used in any species and are still widely humans livestock. However, data on their pharmacokinetics animals is limited, especially after repeated administration. Evidence exist that chickens (Gallus gallus) salicylate (SA) may induce its own elimination. The aim of this study was investigate egg residues during administration sodium (SS) laying hens. Pharmacokinetics SA assessed 14 d oral SS at daily doses 50 mg/kg...

Despite common use of tylosin in turkeys, the pharmacokinetic (PK) data for this drug turkeys is limited. Within a few months growth, PK drugs undergoes changes that may decrease their efficacy due to variable internal exposure.The objective study was investigate influence age on single intravenous (i.v.) and oral administration at dose 10 50 mg/kg, respectively.Plasma concentrations were measured using high-performance liquid chromatography with UV detection. The parameters assessed by...

The aim of this study was to assess the influence growth on pharmacokinetics sodium salicylate ( SS ) in male turkeys. administered intravenously at a dose 50 mg/kg. Plasma drug concentrations were assessed by high‐performance liquid chromatography, and pharmacokinetic parameters calculated noncompartmental analysis. As age increased from 6 13 weeks (body weight increase 2.35 9.43 kg), median body clearance decreased 1.34 0.87 ml/min/kg. This caused significant mean residence time 3.42 4.44...

Rapid weight gain in turkeys causes a major change the pharmacokinetics of drugs, leading to age-dependent variability internal exposure and, possibly, treatment failure and/or selection for antimicrobial resistance young individuals. The aim study was investigate whether non-linear dosing protocol that accounts previously established allometric relation between enrofloxacin clearance and body (BW) may optimize growing male turkeys. Enrofloxacin administered four times, age 5 16.5 weeks,...