A5007118765- Atomic and Molecular Physics
- Antibiotics Pharmacokinetics and Efficacy
- Nuclear Physics and Applications
- Radiation Therapy and Dosimetry
- Pesticide Residue Analysis and Safety
- Drug Transport and Resistance Mechanisms
- Mass Spectrometry Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Luminescence Properties of Advanced Materials
- Nuclear physics research studies
- Opioid Use Disorder Treatment
- Advanced Chemical Physics Studies
- Gas Sensing Nanomaterials and Sensors
- Biomedical and Engineering Education
- X-ray Spectroscopy and Fluorescence Analysis
- Nanomaterials for catalytic reactions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Poisoning and overdose treatments
- Pharmacogenetics and Drug Metabolism
- Estrogen and related hormone effects
- Diet and metabolism studies
- Dental materials and restorations
- Antibiotic Resistance in Bacteria
- Catalysis and Oxidation Reactions
Wroclaw University of Environmental and Life Sciences
2016-2023
Russian Cancer Research Center NN Blokhin
2010-2012
Russian Academy of Sciences
2012
New types of contactless luminescence nanothermometers, namely, LiAl5O8:Fe3+ and LiAl5O8:Fe3+, Nd3+ are presented for the first time, revealing potential applications in biological systems. The temperature-sensing capability nanocrystals was analyzed wide range temperature (-150 to 300 °C). emission intensity Fe3+ ions is affected by change temperature, which induces quenching 4T1 (4G) → 6A1 (6S) transition situated 1st window. highest relative sensitivity (0 50 °C) found be 0.82% °C (at 26...
Herein, a novel synthesis method of colloidal GdPO4:Mn2+,Eu3+ nanoparticles for luminescent nanothermometry is proposed. XRD, TEM, DLS, and zeta potential measurements confirmed the crystallographic purity reproducible morphology obtained nanoparticles. The spectroscopic properties with different amounts Mn2+ Eu3+ were analyzed in physiological temperature range. It was found that GdPO4:1%Eu3+,10%Mn2+ revealed extraordinary performance noncontact sensing relative sensitivity SR = 8.88%/°C at...
Li+/Eu3+ dual-doped calcium apatite analogues were fabricated using a microwave stimulated hydrothermal technique. XRPD, FT-IR, micro-Raman spectroscopy, TEM and SAED measurements indicated that obtained apatites are single-phased, crystallize with hexagonal structure, have similar morphology nanometric size as well show red luminescence. Lithium effectively modifies the local symmetry of optical active sites and, thus, affects emission efficiency. Moreover, hydrodynamic surface charge...
The pharmacokinetics of florfenicol (FF) and thiamphenicol (TP) after single intravenous (IV) oral (PO) administration was investigated in Mulard ducks. Both antibiotics were administered at a dose 30 mg/kg body weight, their concentrations plasma samples assayed using high-performance liquid chromatography with ultraviolet detection. Pharmacokinetic parameters calculated noncompartmental method. After IV administration, significant differences found for the mean residence time (2.25 ± 0.21...
1. This study evaluated the pharmacokinetic profiles of florfenicol (FF) and thiamphenicol (TP), which are synthetic bacteriostatic antimicrobial drugs, in geese after a single intravenous or oral administration, as well seven doses administered at 12 h intervals. For all treatments, dose was 30 mg/kg.2. After IV clearance volume distribution were low (0.23 ± 0.03 l/h/kg 0.57 0.08 l/kg for FF, 0.23 0.04 0.59 TP, respectively). The elimination half-life similar between products short (2.91...
Co 1– x Mn Fe 2 O 4 ferrite nanoparticles have been synthesized by employing a microwave‐stimulated technique under non‐hydrolytic conditions. Structural, chemical, and morphological characterizations were carried out XRD, SEM‐EDS, TEM techniques. The stability of the their tendency to form agglomerates investigated dynamic light scattering, exploiting effect different biological environments protein stabilization. It was shown that bovine serum albumin adsorption dependent upon...
In this research we subjected samples of poly(L-lactide) (PLLA) extruded film to ultraviolet (193 nm ArF excimer laser) radiation below the ablation threshold. The modified was immersed in Simulated Body Fluid (SBF) at 37 °C for 1 day or 7 days obtain a layer apatite ceramic (CaP) coating on PLLA surface. were characterized by means optical profilometry, which indicated an increase average roughness (Ra) from 25 unmodified over 580 irradiated incubated SBF day. At same time, water contact...
Abstract Enrofloxacin is a concentration‐dependent antimicrobial used in bacterial infections poultry. During few months of turkey's life, pharmacokinetics drugs undergoes substantial changes which may compromise their efficacy due to variability internal exposure (measured by area under the concentration–time curve, AUC). The aim this study was describe effects age on single intravenous (i.v.) and oral administration enrofloxacin at dose 10 mg/kg turkeys. It found that during 2.5‐month‐long...
Examination of fentanyl levels is frequently performed in certain scientific evaluations and forensic toxicology. It often involves the collection very variable blood samples, including lipemic plasma or serum. To date, many works have reported methods for detection, but none them provided information about impact on assay performance caused by an excessive amount lipids. This aspect may be, however, important highly lipophilic drugs like fentanyl. address this issue, we developed liquid...
The precise and reliable determination of buprenorphine concentration is fundamental in certain medical or research applications, particularly pharmacokinetic studies this opioid. main challenge is, however, the development an analytical method that sensitive enough, as detected vivo concentrations often fall very low ranges. Thus, study we aimed at developing a sensitive, repeatable, cost-efficient, easy HPLC protocol for rabbit plasma. In order to obtain this, HPLC-MS2 system was used...
Abstract The human head is a highly complex structure, with combination of hard and soft tissues variety materials interactions. Many researchers have used computational approaches to model the head, several finite element models can be found in literature. However, most them are not geometrically accurate – for instance, brain simplified smooth spherical volume, which poses some concerns regarding boundary conditions geometrical accuracy. Therefore, an advanced 28-year-old, designated as...
Despite common use of tylosin in turkeys, the pharmacokinetic (PK) data for this drug turkeys is limited. Within a few months growth, PK drugs undergoes changes that may decrease their efficacy due to variable internal exposure.The objective study was investigate influence age on single intravenous (i.v.) and oral administration at dose 10 50 mg/kg, respectively.Plasma concentrations were measured using high-performance liquid chromatography with UV detection. The parameters assessed by...
Rapid weight gain in turkeys causes a major change the pharmacokinetics of drugs, leading to age-dependent variability internal exposure and, possibly, treatment failure and/or selection for antimicrobial resistance young individuals. The aim study was investigate whether non-linear dosing protocol that accounts previously established allometric relation between enrofloxacin clearance and body (BW) may optimize growing male turkeys. Enrofloxacin administered four times, age 5 16.5 weeks,...
Abstract Intravenous lipid emulsions (ILE), among other uses, are utilized in the treatment of poisonings caused by lipophilic substances. The body evidence regarding benefits this is growing but information about opioids-ILE interaction still very scarce. In work, impact ILE on distribution buprenorphine, fentanyl and butorphanol used various concentrations (100–500 ng/ml) was investigated. Two different vitro models were used: disposition drugs plasma after ultracentrifugation into...