A5008478395- Immune responses and vaccinations
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Epigenetics and DNA Methylation
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical studies and practices
- Childhood Cancer Survivors' Quality of Life
- Immune cells in cancer
- Tuberculosis Research and Epidemiology
- Ethics in Clinical Research
- Child and Adolescent Health
- Neonatal Respiratory Health Research
- Colorectal Cancer Screening and Detection
- Immunodeficiency and Autoimmune Disorders
- Global Cancer Incidence and Screening
- Adolescent and Pediatric Healthcare
Royal Children's Hospital
2020-2023
Murdoch Children's Research Institute
2020-2023
The University of Melbourne
2020-2022
Office of Infectious Diseases
2021
Abstract Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report convalescent innate immune responses in 48 children 70 infected with, or exposed to, SARS-CoV-2. We find clinically SARS-CoV-2 infection is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells natural...
Trained immunity describes the capacity of innate immune cells to develop heterologous memory in response certain exogenous exposures. This phenomenon mediates, at least part, beneficial off-target effects BCG vaccine. Using an vitro model trained immunity, we show that exposure induces a persistent change active histone modifications, DNA methylation, transcription, and adenosine-to-inosine RNA modification human monocytes. By profiling methylation circulating monocytes from infants MIS...
BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging As a readily available, inexpensive intervention that has well-established safety profile, is good candidate for protecting healthcare workers (HCWs) and other vulnerable groups against COVID-19.
Children have reduced severity of COVID-19 compared to adults and typically mild or asymptomatic disease. The immunological mechanisms underlying these age-related differences in clinical outcomes remain unexplained. Here, we quantify 23 immune cell populations 141 samples from children with their PCR-negative close household contacts at acute convalescent time points. displayed marked reductions myeloid cells during infection, most prominent under the age five. Recovery infection both was...
Background This study aims to describe the use of a paediatric advice line (PAL) provided parents whose infants were recruited large randomised controlled trial (RCT), including number and types medical concerns addressed, seasonal variability call outcomes. Additionally, sociodemographic characteristics children those who used PAL are compared with did not. Methods Prospective cohort 1246 nested in Melbourne Infant Study: BCG for Allergy Infection Reduction (MIS BAIR) RCT. All MIS BAIR...