Huan Yan

ORCID: 0000-0001-7546-8087
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About
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Research Areas
  • Thyroid Cancer Diagnosis and Treatment
  • Thyroid and Parathyroid Surgery
  • Epigenetics and DNA Methylation
  • Lung Cancer Treatments and Mutations
  • Radiomics and Machine Learning in Medical Imaging
  • Genetic factors in colorectal cancer
  • Genetic Syndromes and Imprinting
  • Traffic control and management
  • Traffic Prediction and Management Techniques
  • IPv6, Mobility, Handover, Networks, Security
  • Heavy metals in environment
  • Lung Cancer Research Studies
  • Transportation Planning and Optimization
  • Chromatin Remodeling and Cancer
  • Vitamin D Research Studies
  • Breast Cancer Treatment Studies
  • Protist diversity and phylogeny
  • Coal and Its By-products
  • Multiple and Secondary Primary Cancers
  • Ovarian cancer diagnosis and treatment
  • Head and Neck Anomalies
  • Advancements in Transdermal Drug Delivery
  • Metastasis and carcinoma case studies
  • Mine drainage and remediation techniques
  • Renal cell carcinoma treatment

Chinese PLA General Hospital
2024

University of South China
2024

Hunan Cancer Hospital
2024

Central South University
2014-2024

Tsinghua University
2006-2023

University of Electronic Science and Technology of China
2022

National University of Defense Technology
2021

NorthShore University HealthSystem
2018-2020

Tianjin Medical University
2010-2015

UCLA Medical Center
2015

Abstract Aims We previously showed that the nab-paclitaxel plus S-1 (NPS) regimen had promising effects against metastatic pancreatic ducal adenocarcinoma (mPDAC), whose efficacy however could not be precisely predicted by routine biomarkers. This prospective study aimed to investigate values of mutations in circulating tumor DNA (ctDNA) and their dynamic changes predicting response mPDAC NPS chemotherapy. Methods Paired tissue blood samples were prospectively collected from patients with...

10.1186/s12967-024-04989-z article EN cc-by Journal of Translational Medicine 2024-02-20

Abstract Sinomenine is an anti‐rheumatoid arthritis (RA) drug derived from the Sinomenium acutum. The major site of RA treatment within synovial compartment. However, pharmacokinetic and penetration into fluid (SF) sinomenine have not been reported. In our study, pharmacokinetics SF systemic electroporation administered were investigated by microdialysis incorporated with HPLC‐MS/MS. went plasma more rapidly higher peak concentration ( C max ) intramuscular injection compared oral...

10.1002/bmc.3369 article EN Biomedical Chromatography 2014-11-07

Travel time estimation is one of the core tasks for development intelligent transportation systems. Most previous works model road segments or intersections separately by learning their spatio-temporal characteristics to estimate travel time. However, due continuous alternations and in a path, dynamic features are supposed be coupled interactive. Therefore, modeling them limits further improvement accuracy estimating To address above problems, novel graph-based deep framework proposed this...

10.1145/3627819 article EN ACM Transactions on Spatial Algorithms and Systems 2023-10-28

10.1016/j.expthermflusci.2006.06.007 article EN Experimental Thermal and Fluid Science 2006-09-07

The aim of this study was to the expression Syk gene and methylation in its promoter region lung cancer investigate relationship between silencing DNA cell lines. Real-time PCR immunohistochemistry were used examine specimens from 3 lines 16 patients (tumor tissues adjacent normal tissues). MSP analyze status region. We also investigated role restoring by using a methyltransferase inhibitor, 5-aza-CdR, suppressing invasion No detected In patient samples, significantly lower tumor than that...

10.4149/neo_2011_01_89 article EN Neoplasma 2010-11-10

Background The second-line treatment of neuroendocrine tumors (NETs) unknown primary origin remains uncertain. This report presented a patient who received octreotide plus IBI-318 anlotinib as for multiple metastatic NETs lesions after the failure everolimus. Case presentation A 32-year-old male with elevated CEA (197.83 ng/ml) without specific symptoms. contrast-enhanced computed tomography (CT) scan showed lymph nodes and low-density nodules in liver undetermined nature. right...

10.3389/fonc.2024.1390299 article EN cc-by Frontiers in Oncology 2024-12-11

This study is aimed at evaluating the feasibility of a screening method for pulmonary adenocarcinoma nodules through surface-enhanced Raman spectroscopy (SERS). Objective. Using SERS to measure serum from and healthy subjects, intraoperative biopsy pathological diagnosis was regarded as gold standard labeling samples. To explore application value in differential nodules, benign healthy, we build machine learning model. Method. We collected 116 samples patients. Radiographically confirmed...

10.1155/2022/4368928 article EN cc-by BioMed Research International 2022-06-23

Abstract Background In 2010, a Japanese trial of nonoperative management for papillary thyroid microcarcinomas (PTmC) was published. This study determines if the prevalence in United States has changed and there are predictors this approach. Methods Patients treated PTmC between 2004 2015 National Cancer Data Base were identified. Inclusion criteria were: classic or follicular variant cancer histology, tumor size 1 to 10 mm, cN0 disease no extrathyroidal extension metastatic disease....

10.1002/jso.25845 article EN Journal of Surgical Oncology 2020-03-18

This study investigated the effect of Ca(H2PO4)2 on pH, leaching toxicity and speciations soil before after it. Different amounts were added to Pb-contaminated stabilized for 30 days. The changes pH tracked during that period. content Pb in was also determined days stabilization. Results showed didn't change much with addition of-Ca(H2PO4)2. When amount reached 3 wt%, met standard limiting level groundwater class III China. found be mainly affected by water-soluble fraction mild acid-soluble...

10.1080/15226514.2021.1952926 article EN International Journal of Phytoremediation 2021-07-22

Travel time estimation is one of the core tasks for development intelligent transportation systems. Most previous works model road segments or intersections separately by learning their spatio-temporal characteristics to estimate travel time. However, due continuous alternations and in a path, dynamic features are supposed be coupled interactive. Therefore, modeling them limits further improvement accuracy estimating To address above problems, novel graph-based deep framework proposed this...

10.48550/arxiv.2105.13591 preprint EN other-oa arXiv (Cornell University) 2021-01-01

Describing the dynamics of information dissemination within social networks poses a formidable challenge. Despite multiple endeavors aimed at addressing this issue, only limited number studies have effectively replicated and forecasted evolving course dissemination. In paper, we propose novel model, DM-NAI, which not considers transfer between adjacent users but also takes into account non-adjacent to comprehensively depict process. Extensive experiments are conducted on six datasets predict...

10.48550/arxiv.2403.13267 preprint EN arXiv (Cornell University) 2024-03-19

Aim: The administration of nab-paclitaxel/carboplatin (nab-PC) as first-line therapy in patients with advanced non-small-cell lung cancer was efficacious and resulted a significantly improved objective overall response rate (ORR) versus solvent-based PC phase ||| trial.Subgroup analysis showed the squamous histology appeared to be predictive factor nab-paclitaxel treatment.This || trial (NCT01236716; CTONG1002) compared eficacy safety

10.1093/annonc/mdu349.35 article EN publisher-specific-oa Annals of Oncology 2014-09-01

10.3724/sp.j.1087.2010.02515 article EN Journal of Computer Applications 2010-11-30

10.1016/s1557-9190(11)70564-9 article EN Clinical Lymphoma & Myeloma 2009-02-01
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