A5087868214- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Computational Drug Discovery Methods
- Asthma and respiratory diseases
- Non-Invasive Vital Sign Monitoring
- Cholinesterase and Neurodegenerative Diseases
- Phosphodiesterase function and regulation
- Metabolomics and Mass Spectrometry Studies
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Animal testing and alternatives
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Pelvic and Acetabular Injuries
- Cardiac pacing and defibrillation studies
- Autoimmune Neurological Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Neurological disorders and treatments
- Drug-Induced Hepatotoxicity and Protection
- Pesticide Exposure and Toxicity
- Sexual function and dysfunction studies
- Genetic factors in colorectal cancer
- Dental Anxiety and Anesthesia Techniques
Rowan University
2023-2024
Tulane University
2024
Rutgers, The State University of New Jersey
2019-2022
Environmental and Occupational Health Sciences Institute
2020
Clinical Orthopaedics and Related Research
2018
Bridgepoint (United Kingdom)
2013
University of California, Irvine
2011-2013
Sichuan University
2013
West China Hospital of Sichuan University
2013
Traditional methodologies for assessing chemical toxicity are expensive and time-consuming. Computational modeling approaches have emerged as low-cost alternatives, especially those used to develop quantitative structure-activity relationship (QSAR) models. However, conventional QSAR models limited training data, leading low predictivity new compounds. We developed a data-driven approach constructing carcinogenicity-related these identify potential human carcinogens. To this goal, we probe...
Abstract Background Postoperative mortality and complications after geriatric hip fracture surgery remain high despite efforts to improve perioperative care for these patients. One factor of particular interest is anesthetic technique, but prior studies on this are limited by sample selection, competing risks, incomplete followup. Questions/purposes (1) Among older patients undergoing fracture, does 90-day differ depending the type anesthesia received? (2) Do emergency department returns...
Helper T effector cytokines implicated in asthma modulate the contractility of human airway smooth muscle (HASM) cells. We have reported recently that a profibrotic cytokine, transforming growth factor (TGF)-β1, induces HASM cell shortening and hyperresponsiveness. Here, we assessed whether TGF-β1 affects ability cells to relax response β2-agonists, mainstay treatment for hyperresponsiveness asthma. Overnight significantly impaired isoproterenol (ISO)-induced relaxation carbachol-stimulated,...
Computational modeling has emerged as a time-saving and cost-effective alternative to traditional animal testing for assessing chemicals their potential hazards. However, few computational studies immunotoxicity were reported, with models available predicting toxicants due the lack of training data complex mechanisms immunotoxicity. In this study, we employed data-driven quantitative structure-activity relationship (QSAR) workflow extensively enlarge limited by revealing multiple targets...
Glucocorticoids (GCs) and β2-adrenergic receptor (β2AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression human airway smooth muscle (HASM), thereby attenuating inflammation hyperresponsiveness that define asthma. Our previous studies showed the pro-fibrotic cytokine, transforming growth factor- β1 (TGF-β1) increases phosphodiesterase 4D (PDE4D) attenuates agonist-induced levels of intracellular cAMP. Decreased cAMP then diminishes β2 relaxation. In current...
s and Programme: EUROANAESTHESIA 2011: The European Anaesthesiology Congress: Monitoring: Equipment Computers
Chen, G.; Zuo, Y. X.; Yang, L.; Chung, E.; Kain, Z. N.; Cannesson, M. Author Information