HIV prevalence among men who have sex with (MSM) and transgender (TG) persons is high increasing in Chiang Mai, northern Thailand.To describe demographic, socioeconomic, sexual behavior interest future prevention trials gay bisexual MSM TG presenting for testing (VCT) pre-screening the iPrEx pre-exposure chemoprophylaxis trail.In 2008-09, MSM/TG participants attending VCT were interviewed tested STI. Univariate multivariate regression analyses done to assess associations infection.A total of...

BackgroundNorthern Thailand has a high burden HIV epidemic among MSM and TG. Oral pre-exposure prophylaxis (PrEP) with tenofovir-emtricitabine demonstrated efficacy in preventing TG Chiang Mai, Thailand. Determinants of PrEP acceptability are needed to gauge the potential uptake this prevention strategy. MethodsFrom January February 2012, 238 participants, who self-reported as HIV-uninfected or unknown status, completed self-administered survey on hand-held computers. Participants were...

Background: Studies have found that late-onset systemic lupus erythematosus (SLE) patients (age at diagnosis 50 years) had less severe disease and milder clinical course, but with higher organ damage mortality rate than early-onset ones < years). Unfortunately, direct comparison of renal manifestations treatment outcomes between late- SLE has been determined rarely. This study aimed to compare nephritis (LN) manifestations, treatment, in patients. Methods: Medical records a cohort tertiary...

Several studies have compared the clinical features and outcomes of late- early-onset systemic lupus erythematosus (SLE) patients. However, these previous were uncontrolled. The current study aimed to compare SLE patients while controlling for sex year at diagnosis (± 1 year).The medical records in a cohort from January 1994 June 2020 reviewed. Late-onset identified as those with an age ≥ 50 years. (age < years) matched by late-onset ratio 2:1. Clinical manifestations, disease activity...

Background HPV infection is common and may cause cancer among men who have sex with (MSM). Anal (HPV+) was found in 85% of HIV-positive (HIV+) 59% HIV-negative (HIV-) MSM Bangkok, central Thailand. As little known about this group northern Thailand, we studied subgroups comprised gay (GM), bisexual (BM), transgender women (TGW). Methods From July 2012 through January 2013, 85 (42.5% 200) GM, 30 (15%) BM, (42.5%) TGW practiced receptive anal intercourse were recruited after informed consent,...

An educational-behavioral intervention has been shown to improve anticoagulation control with warfarin in atrial fibrillation (AF) patients, but widespread application may not be practical. The SAMe-TT2R2 score was formulated identify the likelihood of achieving optimal time therapeutic range (TTR). authors conducted a randomized controlled trial evaluate impact score-guided strategy for an intervention, compared usual care on patient's control. Anticoagulant-naive adult AF patients were or...

Anal cancer, one of human papillomavirus (HPV) related malignancies, has increased in recent decades, particularly among men who have sex with (MSM) and HIV-infected (HIV+) persons. We aimed to explore the prevalence anal squamous intraepithelial lesions (ASIL) using Papanicolau (Pap) screening MSM northern Thailand its associated factors.Two hundreds aged ≥18 years reporting receptive intercourse prior 6 months were recruited from July 2012 through January 2013. Medical history behavioral...

Diabet. Med. 28, 608–611 (2011) Abstract Aims Studies within the Caucasian population with diabetes showed an increased mortality in patients diabetic foot ulcers. However, there were no such studies based on Asian populations. We therefore designed our study association of ulcer population. Methods Ninety‐seven individuals who had previously participated ‘Multidisciplinary Diabetic Foot Protocol’ between 2005 and 2007 at centre followed up 2010 to ascertain their rate. Cox...

Alu elements and long interspersed element-1 (LINE-1 or L1) are two major human intersperse repetitive sequences. Lower methylation, but not LINE-1, has been observed in blood cells of people old age, menopausal women having lower bone mass osteoporosis. Nevertheless, methylation levels also vary among young individuals. Here, we explored phenotypes at birth that associated with people. In 2010, 249 twenty-years-old volunteers whose mothers had participated a study association between weight...

Scabies outbreaks have emerged in the orphanages Chiang Mai, Thailand. Sulfur has been accepted as standard treatment for childhood scabies was administered mass two orphanages. The present study surveys prevalence of these orphans year following program.The authors visited over course 1 year. Children at were examined. Cases and their contacts treated.The 87.3% before treatment, 2 months after reduced to a <10%, which maintained until end (P < 0.01 each visit).Sulfur is effective treating...

Thailand's epidemic of HIV infection, which began in 1988, has primarily involved heterosexual transmission the virus. This study describes changes prevalence and other infectious diseases among blood donors northern Thailand from 1990 through 2001.Serologic screening results demographic data were analyzed 276,066 screened at two collection facilities Chiang Mai, Thailand, 2001.The peaked 1991 to 1993 4.04 percent then declined 0.38 2001. The overall infection was 2.16 percent; higher male...

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Abstract Studies on predicting factors for adverse pregnancy outcomes (APOs) in Thai patients with systemic lupus erythematosus (SLE) are limited. This retrospective observation study determined APOs and their predictors SLE. Medical records of pregnant SLE a cohort, seen from January 1993 to June 2017, were reviewed. Ninety pregnancies (1 twin pregnancy) 77 identified. The mean age at conception was 26.94 ± 4.80 years. At conception, 33 (36.67%) had active disease, 23 (25.56%) hypertension,...

Abstract Background Rates of overweight and obesity among women reproductive age have been steadily increasing worldwide in Thailand. There is mounting evidence that maternal during pregnancy associated with an increased risk other adverse health outcomes the offspring, but such data are lacking for We examined associations between body mass index (BMI) anthropometry (particularly likelihood obesity) cardiometabolic parameters young adult offspring. Methods This was a prospective follow-up...

Necrotizing fasciitis (NF) is a high morbidity and mortality disease also demands economic resources. The standard treatment of NF surgical debridement proper dressing for wound bed preparation. efficacy silver alginate can inhibit the growth microorganisms keep environment clean However an optimal to manage such wounds has yet emerge. patients who were admitted between April 2013 May 2016 randomized have using either (Ag group) or normal saline solution gauze (NSS group). 4 main outcomes...

HLA studies in patients with systemic sclerosis (SSc) have shown variable results. This study aimed to examine the association of class I and II risk alleles Thai SSc patients, clarify contribution pathogenesis clinical manifestations. Blood samples from 92 135 healthy controls (HCs) were collected. Eleven loci (HLA-A, B, C) (HLA-DR, DP, DQ) genes determined by a 3-field (6-digit) analysis using Next Generation DNA Sequencing (NGS) method. Anti-topoisomerase-I antibodies (ATA)...

The aim of this study was to compare body fat distribution using dual-energy X-ray absorptiometry (DXA) in young adult subjects with metabolic syndrome (MS) those without MS and also determine whether a significant association existed between total mass (FM) along the effect birth weight.This cross-sectional conducted on 393 (175 male, 218 female). Body index (BMI), waist circumference, blood pressure, triglyceride, high-density lipoprotein cholesterol glucose levels were determined. Total...

In late 2009, the Thai Ministry of Public Health provided two million doses monovalent pandemic influenza H1N1 2009 vaccine (Panenza®, Sanofi Pasteur), which was only formulation available in Thailand, to persons at risk more severe manifestations disease including HIV infection. Several studies have shown poorer immune responses vaccines HIV-infected individuals. There are limited data this population resource-limited countries.At day 28 post-vaccination, seroconversion found 32.0% (95%CI...

Abstract Aim: To identify risk factors associated with and evaluate algorithms for predicting Chlamydia trachomatis (CT) Neisseria gonorrhoeae (NG) cervical infections in women attending family planning clinics Thailand. Methods: Eligible were recruited from all regions The followed at 3‐month intervals 15–24 months. At each visit, the interviewed interval sexually transmitted infection (STI) history past 3 months, recent sexual behavior, contraceptive use. Pelvic examinations performed...

Abstract We examined the associations between caesarean section (CS) delivery and cardiovascular risk factors in young adults Thailand. Participants were 632 offspring from a birth cohort Chiang Mai (Northern Thailand), born 1989–1990 assessed 2010 at mean age of 20.6 years, including 57 individuals (9.0%) by CS 575 vaginally. Clinical assessments included anthropometry, blood pressure (BP), carotid intima-media thickness, fasting glucose, insulin, lipid profile. Young had systolic BP (SBP)...

Studies on polymorphisms of the cytotoxic T lymphocytes associated antigen-4 (CTLA-4) genes in rheumatic disease patients are limited Southeast Asia. This pilot study aimed to determine CTLA-4 Thai with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and sclerosis (SSc), correlate them serology.One-hundred RA, 70 SLE 50 SSc patients, 99 healthy controls (HCs) were included this study. Polymorphisms gene at +49A/G, -318C/T, -1661A/G -1722T/C loci determined by polymerase chain...