A5041294977- Pesticide Exposure and Toxicity
- Birth, Development, and Health
- Pesticide Residue Analysis and Safety
- Toxic Organic Pollutants Impact
- Thyroid Disorders and Treatments
- Breastfeeding Practices and Influences
- Thyroid Cancer Diagnosis and Treatment
- Pesticide and Herbicide Environmental Studies
- Bone health and osteoporosis research
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Carcinogens and Genotoxicity Assessment
- Environmental Toxicology and Ecotoxicology
- Obesity, Physical Activity, Diet
- Pregnancy and preeclampsia studies
- Cerebrovascular and Carotid Artery Diseases
- Body Composition Measurement Techniques
- Nutritional Studies and Diet
- Peripheral Artery Disease Management
- HIV Research and Treatment
- Effects and risks of endocrine disrupting chemicals
- T-cell and B-cell Immunology
- Thyroid and Parathyroid Surgery
- Child and Adolescent Health
- Nutrition and Health in Aging
Chiang Mai University
2015-2024
University of Chicago
1991-1994
Howard Hughes Medical Institute
1991
Universidade de São Paulo
1991
Graves' disease (GD) is an autoimmune of the thyroid gland. Genes of, or closely associated to, HLA complex are assumed to contribute genetic predisposition GD. We have previously reported increased frequency HLA-DR3/DQ2 in Caucasian patients with GD, and recently importance Dw24 encoded by DRB3 gene has been suggested. To further investigate associations GD these genes, 94 unrelated 75 control subjects were typed for HLA-DRB3, -DRB1, -DQA1, -DQB1, using sequence-specific oligonucleotide...
This open-label, randomized, controlled, crossover trial assessed the effect of daily virgin coconut oil (VCO) consumption on plasma lipoproteins levels and adverse events. The study population was 35 healthy Thai volunteers, aged 18-25. At entry, participants were randomly allocated to receive either (i) 15 mL VCO or (ii) 2% carboxymethylcellulose (CMC) solution (as control), twice daily, for 8 weeks. After weeks, had an 8-week washout period then crossed over take alternative regimen...
Possible genetic effects on the development of autoimmune thyroid disease were studied by analysis restriction fragment length polymorphisms (RFLPs) candidate genes. Peripheral blood leukocyte DNA was obtained from 65 Caucasian patients with Graves' disease, 63 Hashimoto's thyroiditis, and controls. RFLP carried out genomic DNA, using probes for DRβ, DQα, DQβ, DPα, DPβ, T-cell receptor TCRα, peroxidase. The methodology allowed HLA-DR DQ typing provided information specific patterns related...
Highly active antiretroviral therapy (HAART) has recently been implemented in Thailand. Its long-term effects have not clearly evaluated. The objective of this study was to estimate the prevalence lipodystrophy (LD) and other metabolic changes HIV-infected children receiving HAART.Ninety who began HAART (either nevirapine or efavirenz, together with lamivudine stavudine) were prospectively followed. LD assessed by waist-to-hip ratio checklist. Hypercholesterolaemia defined as total...
In this study, the enzyme-linked immunosorbent assays (ELISA) were modified to detect 3-PBA in plasma (including adducted form) and urine among a large group of consumers farmers an agricultural area. The samples collected on same day morning from 100 (50 females, 50 males) Fang district, Chiang Mai province, northern Thailand. ELISA was very sensitive having IC50 value 26.7 15.3 ng/mL, limit quantitation 5 2.5 ng/mL detection 1.08 1.94 for urine, respectively. These methods had low (< 5%)...
Several studies indicated organophosphate (OP) and neonicotinoid (NEO) insecticides are endocrine disruptors; however, data scarce. This cross-sectional study recruited 143 male farmworkers aged 18–40 years in Fang district, Chiang Mai province, northern Thailand. OP exposure was assessed by measuring urinary dialkylphosphate (DAPs) using a gas-chromatography flame photometric detector. Urinary NEOs, their metabolites (NEO/m) serum steroid hormones were measured liquid chromatography–tandem...
Graves' disease (GD) is an autoimmune thyroid and associated with human leukocyte antigen (HLA)-DR3 -DQA1*0501 in caucasians. The incidence of GD 5 times higher females than males, possibly due to their greater immune reactivity. Although many attempts have been made correlate HLA phenotypes clinical features little attention has paid possible heterogeneous distribution among patients different sexes. To investigate this possibility, 133 (26 males) unrelated caucasian 104 (43 control...
Context: Thyroid cancer is among the 10 most common malignancies in populations Asia Pacific region, where access to various relevant health care resources varies widely. Objective: An expert consensus conference was held define regional patterns of practice and guidelines for optimal management well-differentiated epithelial thyroid carcinomas. Results: Practice vary from country country, as would be anticipated form their variety ethnic racial populations, systems, economies, cultures....
Alu elements and long interspersed element-1 (LINE-1 or L1) are two major human intersperse repetitive sequences. Lower methylation, but not LINE-1, has been observed in blood cells of people old age, menopausal women having lower bone mass osteoporosis. Nevertheless, methylation levels also vary among young individuals. Here, we explored phenotypes at birth that associated with people. In 2010, 249 twenty-years-old volunteers whose mothers had participated a study association between weight...
We have conducted biochemical and genetic studies in five unrelated families (denoted A, C, R, P, G), which included nine goitrous subjects (five borderline euthyroid four hypothyroid) with complete (n = 6) or partial 3) thyroid peroxidase (TPO) deficiency. Thyroid tissue was obtained from subjects, respectively, R. No iodide organification incorporation into protein present A C. The two affected siblings family R had a low normal thyroperoxidase activity. Using 0.8-kilobase (kb) cDNA clone...
Highly active antiretroviral therapy (HAART) is reported to cause insulin resistance among adults, but effects on children are less clear. We attempted describe the prevalence of HIV-infected receiving HAART.Insulin was assessed at 96 weeks treatment with nonnucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (nevirapine or efavirenz stavudine and lamivudine) in Chiang Mai, Thailand. Insulin defined as homeostasis model assessment for (HOMA-IR) >/=3.16, fasting c-peptide >/=4.40...
Background Maternal obesity is associated with an increased risk of large-for-gestational-age births and childhood obesity. However, evidence on its potential associations long-term offspring body composition remains limited. This prospective cohort study examined between maternal mass index (BMI) during pregnancy in the young adult offspring. Methods Participants were from a birth Chiang Mai (Thailand). BMI was assessed at first antenatal clinic visit (≤24 weeks gestation) 1989–1990. In...
ABS
Abstract Background Rates of overweight and obesity among women reproductive age have been steadily increasing worldwide in Thailand. There is mounting evidence that maternal during pregnancy associated with an increased risk other adverse health outcomes the offspring, but such data are lacking for We examined associations between body mass index (BMI) anthropometry (particularly likelihood obesity) cardiometabolic parameters young adult offspring. Methods This was a prospective follow-up...