A low-value by-product of cold-pressed sesame oil is defatted black cake (DBSC). The remaining protein and essential amino acids may be utilized as a renewable biological source to produce bioactive products. bioactivities the hydrolysate from its peptide fractions were examined in this study for vitro antioxidant activity inhibition DPP-IV, ACE, α-amylase, α-glucosidase, pancreatic lipase. By using Flavourzyme hydrolyze DBSC, followed by ultrafiltration, with sizes <3, 3−10, >10 kDa...

Marigolds (Tagetes spp.) are major sources of bioactive compounds. The flowers used to treat a variety illnesses and have both antioxidant antidiabetic effects. However, marigolds exhibit wide range genetic variations. Because this, the compounds biological activities plants differ between cultivars. In present study, nine marigold cultivars grown in Thailand were evaluated for their compound content, as well activities, using spectrophotometric methods. results showed that Sara Orange...

This research aimed to enhance the physicochemical and antioxidant properties of dried whole longan fruit using Maillard reaction or non-enzymatic glycosylation (glycation) in a moist-dry-heating system at 60 °C with approximately 75% relative humidity for 5-50 days. During reaction, browning index (BI) fruits increased significantly while lightless, redness yellowness decreased. Interestingly, rare sugars especially D-psicose D-allose gradually by 2-3 folds when compared initial reaction....

Hypertension is a widespread and life-threatening condition affecting one-third of adults globally. In low- middle-income countries, like Malawi, the burden hypertension escalating due to inadequate healthcare resources lifestyle changes. Family members often become primary caregivers, playing crucial role in managing through support adherence treatment. This study examined caregivers’ knowledge retention by evaluating their pre- post-health education levels. was prospective cross-sectional...

Background Exposure to fine particulate matter (PM2.5) is known increase oxidative stress, impacting health adversely. This study examines the relationship between PM2.5 exposure and stress biomarkers in Chiang Mai, Thailand. Methods A pilot prospective observational was conducted Samoeng District, including 25 healthy participants (age 25–60 years). Urine samples were collected during high (March–April 2023) low (May–July seasons. concentrations monitored daily from Northern Thailand Air...

Exposure to fine particulate matter (PM2.5) is linked increased systemic inflammation, particularly in individuals with metabolic syndrome (MS). This study assessed the impact of nutrition and PM2.5 exposure on inflammatory markers MS. A total 50 participants (25 MS, 25 healthy controls) were monitored during a high-PM2.5 period (HEP) low-PM2.5 (LEP). Dietary intake, health assessments, markers—TNF-α, IL-6, CRP—were evaluated. The MS group had significantly higher BMI, fasting blood glucose,...

Hepcidin is a peptide hormone that regulates the homeostasis of iron metabolism. The N-terminal domain hepcidin conserved amongst range species and capable binding CuII NiII through amino terminal copper–nickel motif (ATCUN). It has been suggested copper to may have biological relevance. In this study we investigated with model peptides containing ATCUN motif, fluorescently labelled using MALDI-TOF mass spectrometry. As albumin, it was found tetrapeptide models possessed higher affinity for...

Thua-nao, or Thai fermented soybeans, is a traditional Lanna food in Northern Thailand. It produced by using specific bacterial species called Bacillus subtilis var. Thua-nao. We investigated the antioxidant activity and cytotoxic effect of isoflavones from The phenolic compound contents total flavonoid were determined spectrophotometry. was examined ABTS, FRAP, DPPH assays. isoflavone compositions high-performance liquid chromatography (HPLC) chromatography-mass spectrometry (LC-MS)...

Impacts of the drying process (DP) and long-term storage (LTS) longan pulp products were evaluated for fresh (FLP), golden dried (GDLP), whole (DWLP) after one-year (DWLP_1Y) by assessing physicochemical properties against glycosylation reaction bioactivities. All defined as intermediate moisture food (IMF). GDLP containing sulfur dioxide had a lower browning index, whereas DWLP attained light brown to intense color period. Interestingly, DWLP_1Y exhibited remarkable increase in rare sugars...

Exercise training adjuvant to standard compression is considered improve calf muscle pump dysfunction in venous leg ulcer (VLU) and subsequent healing. The objectives of this trial were assess the effectiveness a tailored exercise intervention addition therapy on health-related quality life anticipating wound Twenty-four VLU participants recruited randomly divided into 2 groups. control group was prescribed conventional compression, received plus progressive training. 14-item chronic disease...

The present study aims to investigate the antioxidant activity and cytotoxicity of white mugwort (Artemisia lactiflora) leaf extract in human liver cancer cell line (HepG2 cell). Dried leaves were macerated 80 % (v/v) aqueous ethanol get (WMLE). Spectrophotometrically methods conducted quantify total phenolic content capacity extract, found be 213.33±17.80 mg gallic acid equivalent 27.20±1.06 trolox per gram dry respectively. Cytotoxic effects WMLE on viability cellular defense against...

Abstract Background Rates of overweight and obesity among women reproductive age have been steadily increasing worldwide in Thailand. There is mounting evidence that maternal during pregnancy associated with an increased risk other adverse health outcomes the offspring, but such data are lacking for We examined associations between body mass index (BMI) anthropometry (particularly likelihood obesity) cardiometabolic parameters young adult offspring. Methods This was a prospective follow-up...

The study explored proteomics to better understand the relationship between type 2 diabetes (T2DM) and hypertension (HT) in Thai adults, using shotgun bioinformatics analysis. Plasma samples were taken from 61 subjects: 14 healthy subjects (mean age = 40.85 ± 7.12), 13 with T2DM 57.38 6.03), 16 HT 66.87 10.09), 18 coexisting T2DM/HT 58.22 10.65). Proteins identified liquid chromatography-tandem mass spectrometry (LC-MS/MS). Protein-protein interactions analyzed Search Tool for Retrieval of...

Necrotizing fasciitis (NF) is a high morbidity and mortality disease also demands economic resources. The standard treatment of NF surgical debridement proper dressing for wound bed preparation. efficacy silver alginate can inhibit the growth microorganisms keep environment clean However an optimal to manage such wounds has yet emerge. patients who were admitted between April 2013 May 2016 randomized have using either (Ag group) or normal saline solution gauze (NSS group). 4 main outcomes...

Cellular and mitochondrial damage can be caused by labile iron pool (LIP) mediated reactive oxygen species (ROS). Livers of the thalassemias have highly increased levels LIP ROS. Green tea extract (GTE) epigallocatechin 3-gallatte (EGCG) potentially protect liver inflammation, fibrosis cancer due to their anti-oxidative iron-chelating activities. We studied effects GTE EGCG on intracellular ROS, membrane potential (ΔΨm) in mouse hepatocyte HepG2 cell cultures using specific fluorescent...

Oxidative stress and inflammation are 2 major contributors to numerous life-threatening disorders, including vascular pathologies. Shallots (Allium ascalonicum) a type of red onion which grows in Southeast Asia. Bulbs this plant used both as food ingredient traditional medicine. This study attempted investigate the possible ways that juice extracted from Thai shallot (A.ascalonicum cv. Chiangmai) bulbs could be prevention cardiovascular complications. The antioxidative anti-inflammatory...

To evaluate the iron-chelating properties and free-radical scavenging activities of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) treatment in chronic iron-loaded β-thalassemic (BKO) mice. The BKO mice were fed with a ferrocene-rich diet orally administered CM1 [50 mg/(kg.day)] for 6 months. Blood levels non-transferrin bound iron, labile plasma ferritin (Ft) malondialdehyde determined. an iron 8 months which resulted overload. Interestingly, showed decrease levels, but not...

Introduction: Increased risk of cardiovascular disease in HIV-infected patients was tought to be the cause multiple mechanistic factors, which changing HIV care landscape. Antiretroviral therapy (ART), especially protease inhibitors (PI), is one common treatments that may have some association with this. The mechanism PI comparison other regimens, however, are not clearly understood.&#x0D; Methodology: Age-and gender-match treated either boosted-PI-based regimen (boosted-PI group, N=30) or...

Iron overload associated with oxidative stress is a serious problem in transfusion-dependent patients β-thalassemia major. The increased iron several organs may be caused by higher intestinal absorption along less intensive chelation therapy. Liver could turn facilitate the development or persistence of chronic progressive liver disease. Previous studies have shown that desferrioxamine (DFO) and deferiprone (DFP) substantially reduced body-iron scores transfusional overload. We synthesized...

We examined the long-term health outcomes associated with being born small for gestational age (SGA) or large (LGA). A total of 632 young adults aged ≈20.6 years were recruited from a longitudinal study (Chiang Mai, Thailand) in 2010: 473 appropriate (AGA), 142 SGA, and 17 LGA. The clinical assessments included anthropometry, blood pressure (BP), lipid profile, an oral glucose tolerance test (OGTT). Young SGA 1.8 3.2 cm shorter than AGA (p = 0.0006) LGA 0.019) participants, respectively....

Background: Aegle marmelos (Bael) is one of the important medicinal plants for curing human diseases. Nevertheless, information about cytotoxic and antioxidant effects Bael leaf not much. Objectives: The objective this study to evaluate cytotoxicity activity in hepatocellular carcinoma (HepG2) cell lines. Materials Methods: leaves extract was prepared by 80% (v/v) aqueous ethanol measured total phenolic compound capacity. ability ethanolic inhibit hepatic cancer cells (HepG2 cell) growth...

R.Br. (Betong watercress) contains high levels of secondary metabolites that offer health benefits. However, fresh-cut watercress has a short shelf life. This study aimed to assess the effect drying methods on phytochemical contents, antioxidant activity, and anti-diabetic activity Betong watercress. The was dried using three methods: roasting (R, 50 °C, 40 min); (RD, min at °C 1 h 80 °C); blanching, roasting, (BRD, 30 s blanching 20 °C). Aqueous extracts from each method were analyzed for...