A5024291166- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Molecular Biology Techniques and Applications
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Pancreatic function and diabetes
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Total Knee Arthroplasty Outcomes
- Block Copolymer Self-Assembly
- Electromagnetic Fields and Biological Effects
- Wnt/β-catenin signaling in development and cancer
Houston Methodist
2020-2024
Baylor College of Medicine
2017-2024
National Taiwan Sport University
2020
Center for Translational Molecular Medicine
2019
The University of Texas MD Anderson Cancer Center
2014-2015
National Taipei University of Technology
2012
National Sun Yat-sen University
2010
<h3>Background</h3> Chemoradiotherapy (CRT) remains one of the most common cancer treatment modalities, and recent data suggest that CRT is maximally effective when there generation an anti-tumoral immune response. However, has also been shown to promote immunosuppressive mechanisms which must be blocked or reversed maximize its stimulating effects. <h3>Methods</h3> Therefore, using a preclinical model human papillomavirus (HPV)-associated head neck squamous cell carcinoma (HNSCC), we...
Abstract Agonist CD40 monoclonal antibodies (mAb) is a promising immunotherapeutic agent for cold‐to‐hot tumor immune microenvironment (TIME) conversion. Pancreatic ductal adenocarcinoma (PDAC) an aggressive and lethal cancer known as desert, therefore urgently needs more effective treatment. Conventional systemic treatment fails to effectively penetrate the characteristic dense stroma. Here, it shown that sustained low‐dose intratumoral delivery of mAb via nanofluidic drug‐eluting seed...
<h3>Background</h3> Immune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have shown impressive clinical efficacy, however, most patients do not achieve durable responses. One major therapeutic obstacle is the immunosuppressive tumor immune microenvironment (TIME). Thus, we hypothesized that a strategy combining tumor-directed radiation with TIME immunomodulation could improve...
Pancreatic islet transplantation efficacy for type 1 diabetes (T1D) management is limited by hypoxia-related graft attrition and need systemic immunosuppression. To overcome these challenges, we developed the Neovascularized Implantable Cell Homing Encapsulation (NICHE) device, which integrates direct vascularization facile mass transfer localized immunosuppressant delivery rejection prophylaxis. Here, investigated NICHE allogeneic long-term reversal in an immunocompetent, male rat model. We...
Probiotics exert multiple health benefits, including gastrointestinal health, immunoregulation, and metabolic disease improvement, by modulating microbiota to maintain eubiosis via the hypothalamic–pituitary–adrenal (HPA) brain–gut–microbiome axes. Physiological fatigue, mental stress, discomfort under demands of athletic performance as well immunosuppression are common during endurance training competition. Limited studies investigated functional effects probiotic supplementation on...
Abstract Resistance to currently available targeted therapies significantly hampers the survival of patients with prostate cancer bone metastasis. Here we demonstrate an important resistance mechanism initiated from tumor-induced bone. Studies using osteogenic patient-derived xenograft, MDA-PCa-118b, revealed that tumor cells resistant cabozantinib, a Met and VEGFR-2 inhibitor, reside in “resistance niche” adjacent cancer-induced We performed secretome analysis conditioned medium identify...
Cell encapsulation is an attractive transplantation strategy to treat endocrine disorders. Transplanted cells offer a dynamic and stimulus-responsive system that secretes therapeutics based on patient need. Despite significant advancements, challenge in allogeneic cell maintaining sufficient oxygen nutrient exchange, while providing protection from the host immune system. To this end, we developed subcutaneously implantable dual-reservoir integrating situ prevascularization local...
Loss of E-cadherin and up-regulation mesenchymal cadherins, a hallmark the epithelial-mesenchymal transition, contributes to migration dissemination cancer cells. Expression human cadherin-11 (Cad11), also known as osteoblast cadherin, in prostate increases How Cad11 mediates cell is unknown. Using cytoplasmic domain pulldown assays, we identified angiomotin (Amot), be involved polarity, migration, Hippo pathway, component protein complex. Deletion analysis showed that last C-terminal 10...
Although head and neck squamous cell carcinoma (HNSCC) has in the past been largely associated with tobacco use, human papillomavirus (HPV+) oropharynx cancer recent years emerged as fastest growing type of HNSCC. Patients HPV+ HNSCC have a better prognosis; however, 5-year survival for both HPV− subtypes recurrent or metastatic disease is poor. To gain insights into tumor microenvironments identify potential therapeutic targets, we performed epigenomic deconvolution on 580 samples from TCGA...
A single-layer of breath figure pattern was explored via the dynamical optical images and temperature evolution. The prepared with solution carbon disulfide (CS(2)) dissolved 1% weight concentration polystyrene. evaporation CS(2) considered to be most important role formation pattern. understanding figures will promote technique fabricating an imprinted template demanded hexagonal structures.
Intratumoral immunotherapy holds promise for improving cancer treatment efficacy. However, rapid clearance from the tumor upon bolus volume injections limits efficacy and impedes assessment of dose-dependent effects on immune microenvironment (TIME). To this end, we developed a drug-agnostic nanofluidic implant to deliver within tumor, providing mechanism sustained controlled intratumoral dosing. Diffusive drug elution reservoir is by membrane, which abrogates elimination maximizes...
The fertilized chicken egg chorioallantoic membrane (CAM), a highly vascularized nourishing the developing embryo, also supports rapid growth of three-dimensional tumors from engrafted cells and tumor explants. Because murine xenograft models suffer limitations time, cost, scalability, we propose CAM as rapid, efficient screening tool for assessing anti-tumor efficacy chimeric Ag receptor (CAR) T against solid tumors. We tested human epidermal factor 2 (HER2)-specific CAR luminescent,...
Plasma membrane proteins mainly function to transmit external signals into the cell. Many plasma receptor tyrosine kinases (e.g., HER2 and EGFR) are known mediate oncogenic progression, making them prime targets for cancer therapy. Recently, it has become important identify that differentially expressed in normal versus cells, drug-sensitive drug-resistant or among tumor cells metastasize different organ sites because these may lead identification of therapeutic diagnostic markers. In...
Abstract HER2, commonly referred to as ErbB2, is a receptor tyrosine kinase that, along with EGFR, makes up one of the four members ErbB family proteins. These proteins are expressed in most epithelial cell layers and play key role differentiation. HER2 has been found be overexpressed number human cancers, including breast gastric carcinomas. Overexpression represents potential target for chimeric antigen (CAR) T therapy. CAR clinical trials leukemia lymphoma have demonstrated durable...
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Selective in vivo immune cell manipulation offers a promising strategy for cancer vaccines. In this context, spatiotemporal control over recruitment of specific cells, and their direct exposure to appropriate immunoadjuvants antigens are key effective We present an implantable 3D-printed vaccine platform called the 'NanoLymph' that enables spatiotemporally-controlled cells subcutaneous site. Leveraging two reservoirs each continuous immunoadjuvant release or antigen presentation, NanoLymph...
<h3>Background</h3> Intratumoral immunotherapy is a clinically investigated approach based on the premise that local priming of antitumor immune response can yield durable systemic immunity and avoid toxicities associated with administration. However, direct intratumoral injection rapidly disseminates from tumor, resulting in diminished efficacy undesirable exposure.<sup>1</sup> Variations methods as well lesion type location could further affect bioavailability consequently, clinical...
HER2, commonly referred to as ErbB2, is a receptor tyrosine kinase that, along with EGFR, makes up one of the four members ErbB family proteins. These proteins are expressed in most epithelial cell layers and play key role differentiation. HER2 has been found be overexpressed number human cancers, including breast gastric carcinomas. Overexpression represents potential target for chimeric antigen (CAR) T therapy. CAR clinical trials leukemia lymphoma have demonstrated durable remission...
<p>Legends for Supplemental Tables S1-S2 and Figures S1-S6.</p>