A5102801866- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Venous Thromboembolism Diagnosis and Management
- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Management of metastatic bone disease
- Medical Imaging and Pathology Studies
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Endometrial and Cervical Cancer Treatments
- Radiation Dose and Imaging
- Breast Cancer Treatment Studies
- Cardiac tumors and thrombi
- Neuroendocrine Tumor Research Advances
LMU Klinikum
2015-2025
Ludwig-Maximilians-Universität München
2015-2025
Deutschen Konsortium für Translationale Krebsforschung
2025
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2020-2024
Helmholtz Zentrum München
2024
Heidelberg University
2022
German Cancer Research Center
2022
Leibniz University Hannover
2022
Medical Mission Institute
2013-2014
University of Würzburg
2014
There is a potential for adverse cardiovascular effects in long-term breast cancer survivors following adjuvant radiotherapy (RT). For this purpose, the deep inspiration breath-hold technique (DIBH) has been introduced into clinical practice, to maximally reduce radiation dose heart. However, there are variety of DIBH delivery techniques, patient positioning and visual feedback mechanisms. The aim present study was evaluate application using CatalystTM/SentinelTM system, with special...
Response rates of unselected non–small cell lung cancer (NSCLC) patients to the epidermal growth factor receptor inhibitor erlotinib are low and range from 10% 20%. Early response assessments needed avoid costs side effects inefficient treatments. Here we determined whether early changes in tumor uptake <sup>18</sup>F-FDG can predict progression-free overall survival NSCLC who treated with erlotinib. <b>Methods:</b> Twenty-two (6 men, 16 women; mean age ± SD, 64 13 y) stage III or IV...
To report our initial clinical experience with the novel surface imaging system Catalyst™ (C-RAD AB, Sweden) in connection an Elekta Synergy linear accelerator for daily patient positioning patients undergoing radiation therapy.We retrospectively analyzed of 154 fractions 25 applied to thoracic, abdominal, and pelvic body regions. Patients were routinely positioned based on skin marks, shifted calculated isocenter position treated after correction via cone beam CT which served as gold...
Purpose: To assess the feasibility and early results of online adaptive MR-guided radiotherapy (oMRgRT) liver tumors. Methods: We retrospectively examined consecutive patients with primary or secondary lesions treated at our institution using a 0.35T hybrid MR-Linac (Viewray Inc., Mountain View, CA, USA). Online-adaptive treatment planning was used to account for interfractional anatomical changes, real-time intrafractional motion management 2D cine MRI performed respiratory gating approach....
Knowing the technical characteristics of gated radiotherapy equipment is crucial for ensuring precise and accurate treatment when using techniques such as Deep-Inspiration Breath-Hold gating under free breathing. With one first installations novel surface imaging system Catalyst™ (C-RAD AB, Sweden) in connection with an Elekta Synergy linear accelerator (Elekta via Response Interface, like dose delivery accuracy time delay were investigated prior to clinical implementation treatments our institution.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication following an acute embolism (PE). It frequently diagnosed at advanced stages which concerning as delayed treatment has important implications for favourable clinical outcome. Performing follow-up examination of patients with PE regardless persisting symptoms and using all available technical procedures would be both cost-intensive possibly ineffective. Focusing diagnostic therefore on only symptomatic may...
Abstract Purpose Patients with left-sided breast cancer frequently receive deep inspiration breath-hold (DIBH) radiotherapy to reduce the risk of cardiac side effects. The aim present study was analyze intra-breath-hold stability and inter-fraction reproducibility in clinical practice. Material methods Overall, we analyzed 103 patients receiving using a surface-guided DIBH technique. During each treatment session vertical motion patient continuously measured by surface guided radiation...
We investigated the impact of <sup>18</sup>F-DOPA brain PET/CT on clinical management patients with known or suspected tumors. <b>Methods:</b> A prospective survey referring physicians was conducted. pre-PET questionnaire inquired about indication, tumor histology grade, level suspicion for recurrence, and planned management. Early post-PET questionnaires asked to categorize PET findings as negative, equivocal, positive; assessed primary recurrent tumor; recorded intended changes prompted by...
Volumetric Modulated Arc Therapy (VMAT) techniques have recently been implemented in clinical practice for total-body irradiation (TBI). To date, most still use special couches, translational tables, or other self-made immobilization devices dose delivery. Aim of the present study was to report first results a newly developed rotatable tabletop designed VMAT-TBI.The VMAT-TBI technique theoretically allows any standard positioning device at linear accelerator. Nevertheless, main problem is...
Purpose: Many children with sarcomas undergo whole body 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) and technetium methylene diphosphonate (99Tc-MDP) studies. It is unknown whether the combination of both tests results in more accurate detection bone lesions than 18F-FDG- PET/CT alone. Methods: 99Tc-MDP 18F-FDG scans were each read by 2 “blinded” observers then reviewed side-by-side 3 readers. Bone graded qualitatively on a 5-point scale...
To analyse the outcome of elderly patients (≥70 years) with esophageal cancer treated curative intent radio(chemo)therapy. Fifty five (median 75 receiving radio(chemo)therapy for from 1999 to 2015 were retrospectively analyzed. Most showed locally advanced disease (T3/4:78%, N+:58%) squamous cell histology (74%). Charlson comorbidity score was > 1 in 27%. 48 (87%) received definitive treatment while 7 neoadjuvantly. RT carried out as 3D-conformal or IMRT. Concurrent chemotherapy applied 85%,...
To report our experience with SBRT in primary and secondary liver tumors.We retrospectively analysed 55 patients (70 lesions) a median follow-up of 10 months (range 1-57) treated from 2011 to 2016. All had not been eligible for other local treatment options. Median age was 64 years 64% were male. 27 (36 suffered hepatocellular carcinoma (HCC, Child A:78%, B:18%, C:4%), 28 (34 oligometastatic disease (MD). Treatment planning based on 4D-CT usually after placement fiducials. Dose fractionation...
Abstract Background In unresectable hepatocellular carcinoma several local ablative treatments are available. Among others, radiation based such as stereotactic body radiotherapy (SBRT) and high-dose rate interstitial brachytherapy (HDR BT) have shown good control rates. Methods We conducted a dose comparison between actually performed HDR BT versus virtually planned SBRT to evaluate the respective clinically relevant exposure uninvolved liver tissue. Moreover, coverage conformity indices...
Respiratory monitoring systems are required to supply CT scanners with information on the patient's breathing during acquisition of a respiration‐correlated computer tomography (RCCT), also referred as 4D CT. The respiratory system has provide scanner depends specific scanner. purpose this study is compare two different (Anzai Gating System; C‐RAD Sentinel) respect their applicability in combination an Aquilion Large Bore from Toshiba. used our clinic does not make use full time dependent...
Abstract Purpose To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192 Ir calculated according to current-standard TG-43U1 protocol model-based calculation following TG-186 protocol. Methods We retrospectively evaluated volume histogram (DVH) parameters liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous...