A5027683337- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Statistical Methods in Clinical Trials
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Prostate Cancer Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Organ Transplantation Techniques and Outcomes
- Histone Deacetylase Inhibitors Research
- Cancer survivorship and care
- Multiple Myeloma Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Retinal and Macular Surgery
- Intensive Care Unit Cognitive Disorders
- Optimal Experimental Design Methods
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Organ Donation and Transplantation
- Acute Myeloid Leukemia Research
- Colorectal Cancer Screening and Detection
Heidelberg University
2021-2025
Zimmer Biomet (Germany)
2021-2025
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2024
Medical University of Vienna
2017-2023
University Hospital Heidelberg
2021-2023
Saarland University
2022
University of Klagenfurt
2022
Statistics Austria
2017-2021
Zimmer Biomet (Netherlands)
2021
Délégation Paris 7
2011-2019
Export Late antibody-mediated rejection (ABMR) is a leading cause of kidney allograft failure. Uncontrolled studies have suggested efficacy the proteasome inhibitor bortezomib, but no systematic trial has been undertaken to support its use in ABMR. In this randomized, placebo-controlled (the Bortezomib Antibody-Mediated Kidney Transplant Rejection [BORTEJECT] Trial), we investigated whether two cycles bortezomib (each cycle: 1.3 mg/m2 intravenously on days 1, 4, 8, and 11) prevent GFR...
Abstract Patients with cancer are at high risk of severe coronavirus disease 2019 (COVID-19), morbidity and mortality. Furthermore, impaired humoral response renders acute respiratory syndrome 2 (SARS-CoV-2) vaccines less effective treatment options scarce. Randomized trials using convalescent plasma missing for high-risk patients. Here, we performed a randomized, open-label, multicenter trial ( https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001632-10/DE ) in hospitalized...
Anastomotic leakage following colorectal resection remains one of the most significant complications with relevant morbidity and mortality. There is evidence that a higher number stapler firings for rectal division can affect leak rate in double stapling anastomosis. However, there are no data concerning compression We present our institutional experience addressing this issue.This retrospective review prospective database patients undergoing colonic benign malignant indications between...
Purpose: To investigate the impact of subretinal drusenoid deposits (SDD) and photoreceptor integrity on global local geographic atrophy (GA) progression. Methods: Eighty-three eyes 49 patients, aged 50 years older with GA secondary to age-related macular degeneration (AMD), were prospectively included in this study. Participants underwent spectral-domain optical coherence tomography (SD-OCT) fundus autofluorescence (FAF) imaging at baseline after 12 months. The junctional zone presence SDD...
Purpose: To refine estimates of macular soft drusen abundance in eyes with age-related degeneration (AMD) and evaluate hypotheses about biogenesis, we investigated topographic distribution growth rates by optical coherence tomography (OCT). We compared results to retinal features similar topographies (cone density pigment) healthy eyes. Methods: In a prospective study, AMD were identified human observers OCT volumes analyzed computer-assistance. Published histologic data for cone densities...
Summary Background Endoscopic band ligation ( EBL ) is used for primary PP and secondary prophylaxis SP of variceal bleeding. Current guidelines recommend combined use non‐selective beta‐blockers NSBB s) , while in either or should be used. Aim To assess (re‐)bleeding rates mortality cirrhotic patients receiving Methods (Re‐)bleeding were retrospectively assessed with without concomitant therapy after first . Results Seven hundred sixty‐six oesophageal varices underwent from 01/2005 to...
The faecal occult blood test (FOBT) has proven efficiency at screening populations for an average risk of colorectal cancer. Mortality related to this cancer decreases by 15-18% among adults, 50-74 years old, tested every 2 years. A participation rate least 50% is desirable. This not yet been reached in most French regions.To explore the obstacles mass France.In 2009, five focus groups were conducted different areas physicians' FOBT screening. patients' assessed semi-structured interviews....
Abstract Objective Post‐traumatic stress disorder (PTSD) is a severe psychiatric disorder, which might develop after traumatic event, like cancer diagnosis, and threatens the patient's psychological and/or physiological integrity. Anxiety, depression, mental distress are known to be common in patients; however, frequency of PTSD was not investigated thoroughly this patient group so far. Here, we aim screen patients for symptoms determine possible correlation with anxiety, distress. Methods...
Abstract Background Normofractionated radiation regimes for definitive prostate cancer treatment usually extend over 7–8 weeks. Recently, moderate hypofractionation with doses per fraction between 2.2 and 4 Gy has been shown to be safe feasible oncologic non-inferiority compared normofractionation. Radiobiologic considerations lead the assumption that might benefit in particular from terms of tumor control toxicity. First data related ultrahypofractionation demonstrate overall time can...
Aims The aim of the present study was to analyze gender disparities in a large cohort acute coronary syndrome (ACS) patients from Zurich Acute Coronary Syndrome (Z-ACS) Registry. Methods Gender ACS were examined. primary endpoint included in-hospital death rate, and secondary major adverse cardiac cerebrovascular events (MACCEs) at 30-day follow-up. Furthermore, independent predictors for MACCEs identified. Results In total, 2612 with Out these, 23% women. mean age higher women (68.6 ± 12.2;...
Background Apart from superior soft tissue contrast, MR-guided stereotactic body radiation therapy (SBRT) offers the chance for daily online plan adaptation. This study reports on comparison of dose parameters before and after adaptation in SBRT localized prostate cancer. Materials methods 32 consecutive patients treated with ultrahypofractionated cancer within prospective SMILE trial underwent a planning process radiotherapy 37.5 Gy applied 5 fractions. A base plan, derived MRI simulation...
Septic encephalopathy is believed to be a result of neuro-inflammation possibly triggered by endotoxins, such as lipopolysaccharides (LPS). Modulation the immune system property volatile anaesthetics.We aimed investigate systemic and cerebral inflammatory response in LPS-induced sepsis model rats. We compared two different sedation strategies, intravenous propofol anaesthetic sevoflurane, with hypothesis that latter may attenuate neuro-inflammatory processes.Laboratory rat study.Basic...
Purpose To evaluate the impact of drusen size and structure on retinal pigment epithelium (RPE) photoreceptor layers in eyes with early to intermediate age-related macular degeneration (AMD) using polarisation-sensitive optical coherence tomography (OCT). Design Retrospective investigation an observational cross-sectional study. Participants Patients AMD. Methods Twenty-five 25 patients were imaged OCT volume scans. Each scan was manually graded for six distinct characteristics integrity...
Drusen volume (DV) and quantitative autofluorescence (qAF) are potential indicators of progression in age-related macular degeneration (AMD). This prospective observational study examined the association between DV qAF retinal pigment epithelium.Eighty-eight eyes 52 patients with early intermediate AMD were included. The mean follow-up was 9.2 ± 5.6 months, resulting 312 examinations. extracted from 6 × 6-mm spectral-domain optical coherence tomography scans. measured using a rotated Delori...
Purpose: To investigate geographic atrophy (GA) progression using quantitative autofluorescence (qAF) in eyes with solitary GA. Methods: Forty-three of 26 patients (age 79.7 ± 7.2 years; 28 women; 16 pseudophakic) underwent spectral-domain optical coherence tomography and qAF imaging at baseline after 12 months. The junctional zone (A JZ ) a nonaffected 300- µ m-wide control area C were delineated on scans transferred to the image. Linear mixed models calculated association between GA qAF,...
Abstract Perioperative stroke is a devastating complication after coronary artery bypass graft (CABG) surgery, with atherosclerosis of the ascending aorta as important risk factor. During surgical manipulation, detachment plaques can lead to consecutive embolization into brain-supplying arteries. High-pitch computed tomography angiography (HP-CTA) represents non-invasive imaging modality, which provides opportunity for comprehensive aorta, including plaque detection and advanced...
Abstract Introduction Chronic back pain is a widespread medical condition associated with high socioeconomic costs and increasing prevalence. Despite the advanced implementation of multidisciplinary approaches, providing satisfactory treatment offer for those affected often not possible. Exposure therapy (EXP) promises to be an effective economical form in previous pilot study showed superior cognitive behavioral (CBT) reducing perceived limitations movement. The current aims further compare...