A5084010100- Genetics, Aging, and Longevity in Model Organisms
- Spaceflight effects on biology
- Mitochondrial Function and Pathology
- Prostate Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Space Science and Extraterrestrial Life
- Sperm and Testicular Function
- Surgical Simulation and Training
- Cardiovascular and exercise physiology
- Reproductive Health and Technologies
- Circadian rhythm and melatonin
- Transcranial Magnetic Stimulation Studies
- Prostate Cancer Treatment and Research
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Space Exploration and Technology
- Endoplasmic Reticulum Stress and Disease
- Enhanced Recovery After Surgery
- Frailty in Older Adults
- Epigenetics and DNA Methylation
- Selenium in Biological Systems
- Delphi Technique in Research
Lancaster University
2018-2025
Bridge University
2024
Memorial Sloan Kettering Cancer Center
2023
South Tipperary General Hospital
2023
University of Exeter
2017-2021
University of the West of Scotland
2021
East Lancashire Hospitals NHS Trust
2021
Furness College
2018-2020
University of Nottingham
2013-2020
Weill Cornell Medicine
2020
Fibroblast growth factor 21 (FGF21) secretion has been shown to respond directly carbohydrate consumption, with glucose, fructose, and sucrose all reported increase plasma levels of FGF21 in rodents humans. However, consumption also results insulin.The aim this study was examine the combined independent effects hyperglycemia hyperinsulinemia on total bioactive postprandial period humans, determine whether effect is attenuated conditions altered insulin action.Circulating insulin, FGF21,...
Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden.C. elegans, model organism for investigating mechanisms ageing, also displays sarcopenia, but underlying mechanism(s) remain elusive.Here, we use C. elegans natural scaling lifespan in response to temperature examine relationship between mitochondrial content, function, sarcopenia.Mitochondrial content maximal ATP production rates (MAPR) display an inverse lifespan, while onset MAPR direct...
Aims: Cells have developed quality control systems for protection against proteotoxicity. Misfolded and aggregation-prone proteins, which are behind the initiation progression of many neurodegenerative diseases (ND), known to challenge proteostasis network cells. We aimed explore role DNJ-27/ERdj5, an endoplasmic reticulum (ER)-resident thioredoxin protein required as a disulfide reductase degradation misfolded in well-established Caenorhabditis elegans models Alzheimer, Parkinson Huntington...
To explore the views of obstetrics and gynaecology (O&G) general surgery (GS) trainees consultants on laparoscopic skills considered necessary to achieve certificate completion training (CCT) identify any mismatch between in their expectations these skills. A prospective nationwide cross-sectional study UK. national survey distributed through Health Education, England bodies such as Royal College Obstetricians & Gynaecologists, British Society for Gynaecological Endoscopy Association...
To evaluate the effect of epoetin alfa on local disease-free survival (DFS), overall (OS), and cancer treatment-related anemia fatigue in patients with head neck receiving radical radiotherapy curative intent.Patients (N = 301) hemoglobin (Hb) less than 15 g/dL were randomly assigned a ratio 1:1 to receive plus (10,000 U subcutaneously [SC] three times weekly if baseline Hb was < 12.5 g/dL; 4,000 SC > or g/dL) alone. levels monitored weekly. The primary end point DFS, defined as time from...
Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies including Duchenne and Becker dystrophies. Although Caenorhabditis elegans an established genetic model for studying mechanisms treatments dystrophies, analogous strength-based measurements in this disease are lacking. Here we describe first demonstration direct measurement dystrophin-deficient C. mutants using micropillar-based force system called NemaFlex. We show that dys-1(eg33)...
Self-monitoring of blood glucose forms an important part the management diabetes and prevention hyperglycaemia hypoglycaemia. Current monitoring methods either use needle-prick enzymatic glucose-meters or subcutaneous continuous sensors (CGM) thus, non-invasive measurements could greatly improve self-management diabetes. A wide range sensing techniques have been reported, though achieving a level precision comparable to invasive meters remains challenge. Optical sensors, which utilise...
Living longer without simultaneously extending years spent in good health (“health span”) is an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide (H 2 S) can correct disease-related mitochondrial metabolic deficiencies, and supraphysiological H S concentrations pro span. However, the efficacy mechanisms of mitochondrion-targeted delivery molecules (mtH administered across adult life course are unknown. Using a Caenorhabditis elegans aging model, we compared...
The integrin-adhesome network, which contains >150 proteins, is mechano-transducing and located at discreet positions along the cell-cell cell-extracellular matrix interface. A small subset of known to maintain normal muscle morphology. However, importance entire adhesome for structure function unknown. We used RNA interference knock down 113 putative Caenorhabditis elegans homologs constituting most mammalian 48 proteins localize attachment sites in C. muscle. In both cases, we found >90%...
Muscle is a dynamic tissue that responds to changes in nutrition, exercise, and disease state. The loss of muscle mass function with age are significant public health burdens. We currently understand little about the genetic regulation or age. nematode C. elegans an established model for understanding genomic biological processes interest. This worm's body wall muscles display large degree homology higher metazoan species. Since transparent organism, localization GFP mitochondria sarcomeres...
Extended space travel is a goal of government agencies and private companies. However, spaceflight poses risks to human health, the effects on nervous system have be better characterized. Here, we exploited unique experimental advantages nematode Caenorhabditis elegans explore how affects adult neurons in vivo. We found that animals lived 5 days adulthood International Space Station exhibited hyperbranching PVD touch receptor neurons. also that, presence neuronal proteotoxic stress, promotes...
Isolation and long duration spaceflight are associated with musculoskeletal deconditioning. Mars500 was a unique, high-fidelity analogue of the psychological challenges 520-day manned mission to Mars. We aimed explore effect deconditioning on three outcome measures: (1) if lower limb muscle strength reduced during isolation; (2) type I or II fibres were differentially affected; (3) whether any 70-day exercise interventions prevented isolation-induced loss strength.Six healthy male subjects...
Muscle anabolic resistance to dietary protein is associated with obesity and insulin resistance. However, the contribution of excess consumption fat not well studied. The aim these studies was test hypothesis that acute short-term overload will impair skeletal muscle synthetic response ingestion. Eight overweight/obese men [46.4 ± 1.4 yr, body mass index (BMI) 32.3 5.4 kg/m 2 ] participated in feeding study, which consisted two randomized crossover trials. On each occasion, subjects ingested...
The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines growth factors. A secondary aim was whether a novel sprint interval training (SIT) intervention (3 × 20 s 'all out' static sprints, twice week for 8 weeks) would affect inflammatory markers in older men.Nine men [68 (1) years] eleven younger [28 (2) comprised group. Aerobic fitness were taken at baseline both groups following SIT group.Interleukin (IL)-8, vascular endothelial factor...
Abstract A non-invasive glucose sensing device could revolutionise diabetes treatment. Near Infrared (NIR) spectroscopy is a promising technology for sensing; however, the design and choice of components NIR can greatly affect accuracy. We aimed to develop absorption system determine liquid concentrations in physiological range, by evaluating range photodetector light sources. Three detection assemblies were tested: (i) dispersive spectrometer with photodiode array, (ii) Czerny–Turner...