A5100682702- Pharmacological Effects of Natural Compounds
- Bioactive natural compounds
- Bacterial Genetics and Biotechnology
- Lipid metabolism and disorders
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Endoplasmic Reticulum Stress and Disease
- Paraoxonase enzyme and polymorphisms
- Biological and pharmacological studies of plants
- Phytochemistry and Biological Activities
- RNA and protein synthesis mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Traditional and Medicinal Uses of Annonaceae
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Extracellular vesicles in disease
- Carbohydrate Chemistry and Synthesis
- Bacteriophages and microbial interactions
- Characterization and Applications of Magnetic Nanoparticles
- Hepatitis C virus research
- Cancer survivorship and care
Kyungpook National University
2022-2025
Sungkyunkwan University
2021-2024
Inha University
2023
Chosun University
2020-2021
Daegu-Gyeongbuk Medical Innovation Foundation
2021
National Institute of Animal Science
2021
Kyung Hee University
2021
Korea Advanced Institute of Science and Technology
2012
Korean Academy of Science and Technology
2012
Meat from Korean native chickens (KNCs) has high consumer demand; however, slow growth performance and variation in body weight (BW) of KNCs remain an issue. Genome-wide association study (GWAS) is a powerful method to identify quantitative trait-associated genomic loci. A GWAS, based on large-scale KNC population, needed underlying genetic mechanisms related its traits. To BW-associated regions, we performed GWAS using the chicken 60K single nucleotide polymorphism (SNP) panel for 1328...
Cancer incidence and mortality rate are growing worldwide. The effectiveness of cancer therapy depends on the degree development. Anticancer prevention, screening tests, detection precancerous conditions or cancers at an early stage development help to prevent cancer, in event development, they provide best chance for a full recovery. However, most cases advanced there is no method that can fully cure this disease. Recently, natural products have gained more attention therapy. Panax ginseng...
Abstract Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent immuno-metabolic that can progress to hepatic cirrhosis and cancer. NAFLD pathogenesis extremely complex characterized by oxidative stress, impaired mitochondrial function lipid metabolism, cellular inflammation. Thus, in-depth research on its underlying mechanisms subsequent investigation into a potential drug target has overarching effects these features will help in the discovery of effective treatments for...
Heme oxygenase (HO)-1 is a detoxifying phase II enzyme that plays role in both inflammatory and oxidative stress responses. Curdrania tricuspidata widespread throughout East Asia used as therapeutic agent traditional medicine. We investigated whether treatment with sixteen flavonoid or xanthone compounds from C. could induce HO-1 expression HT22 hippocampal cells, RAW264.7 macrophage, BV2 microglia. In these compounds, kuwanon C showed the most remarkable effects. addition, reduced...
Abstract Background TliA is a thermostable lipase secreted by the type 1 secretion system (T1SS) of Pseudomonas fluorescens . The promoted its secretion/chaperone domain located near C-terminus, which composed mainly four Repeat-in-Toxin (RTX) repeats. In order to identify minimal region responsible for secretion, five different copies domain, each involving truncated N-terminal residues and common were acquired named as ABC transporter recognition domains (LARDs). Each LARD was fused...
The root bark of Cudrania tricuspidata has been reported to have anti-sclerotic, anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and cytotoxic activities. In the present study, effect 16 compounds from C. on tumor necrosis factor-α+interferon-γ-treated HaCaT cells were investigated. Among these compounds, 11 decreased IL-6 production 15 IL-8 production. six most effective namely, steppogenin (2), cudraflavone C (6), macluraxanthone B (12),...
Only limited therapeutic agents have been developed for non-alcoholic steatohepatitis (NASH). Glabridin, a promising anti-obesity candidate, has only druggability due to its low in vivo chemical stability and bioavailability. Therefore, we vutiglabridin (VUTI), which is based on glabridin backbone, investigated mechanism of action treating NASH animal models.
Sepsis is an uncontrolled response to inflammatory infection and associated with high levels of mortality morbidity. Rg4 a rare ginsenoside mainly found in the leaves Panax ginseng C. A. Meyer major protopanaxatriol-type black ginseng. In this study, we determined whether affects cecal ligation puncture (CLP)-induced sepsis. Animals were separated into following six groups: control group, CLP-operated CLP plus maslinic acid (MA), (5, 10, or 15 mg/kg). Survival rate, body weight changes,...
Currently, interferon alpha and nucleos(t)ide analogues (NAs) are clinically available to treat hepatitis B virus (HBV) infection. Several NAs, including lamivudine (LMV), adefovir (ADV), entecavir (ETV) tenofovir (TDF or TAF) have been approved administered chronic (CHB) patients. NAs inhibit HBV DNA synthesis by targeting the reverse transcriptase (RT) domain of polymerase. mutations in RT which lead drug resistance against reported, even for TDF TAF highly potent with very low rate....
<title>Abstract</title> Purpose This study evaluated the association between social support during re-entry period and long-term HRQoL in breast cancer survivors using a longitudinal cohort study. Methods is prospective with 275 who reported at 5 10 years after surgery. Social for was assessed Medical Outcome Study-Social Support Survey (MOS-SSS). EORTC QLQ-C30 BR-23. Multivariable linear regression analysis performed to evaluate diagnosis by level of period. Results The mean (SD) 68.5. low...