A5101955166- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Infective Endocarditis Diagnosis and Management
- Infectious Aortic and Vascular Conditions
- Metabolism, Diabetes, and Cancer
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Celiac Disease Research and Management
- Acute Kidney Injury Research
- Cardiovascular Effects of Exercise
- Peripheral Artery Disease Management
- Microscopic Colitis
- Galectins and Cancer Biology
- Hemodynamic Monitoring and Therapy
- Blood transfusion and management
- Vascular Procedures and Complications
- Bone and Joint Diseases
- Infrared Thermography in Medicine
- Spinal Hematomas and Complications
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Actinomycetales infections and treatment
Gifu University
2017-2025
Gifu University Hospital
2018-2024
National Hospital Organization
2024
Okayama Medical Center
2024
Columbia University
2006-2007
Abstract Endothelial glycocalyx coats healthy vascular endothelium and plays an important role in homeostasis. Although cerebral capillaries are categorized as continuous, those the heart lung, they likely have specific features related to their function blood brain barrier. To test that idea, brains, hearts lungs from C57BL6 mice were processed with lanthanum-containing alkaline fixative, which preserves structure of glycocalyx, examined using scanning transmission electron microscopy. We...
Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) characterized by the triad microangiopathic anemia, thrombocytopenia, and acute kidney injury, caused overactivation alternative complement pathway. A 13-year-old Japanese boy with an unremarkable medical history developed symptoms TMA following coronavirus disease 2019 (COVID-19) infection mild respiratory symptoms. He was eventually diagnosed aHUS gain-of-function C3 variant. improved supportive therapy...
Diabetes is associated with defective beta cell function and altered mass. The mechanisms regulating mass its adaptation to insulin resistance are unknown. It unclear whether compensatory hyperplasia achieved via proliferation of existing cells or neogenesis from progenitor embedded in duct epithelia. We have used transgenic mice expressing a mutant form the forkhead-O1 transcription factor (FoxO1) both pancreatic ductal endocrine assess contribution these 2 compartments islet expansion....
Abstract Celiac disease is an immune-mediated disorder triggered by ingestion of wheat gliadin and related proteins in genetically susceptible individuals. In addition to the characteristic enteropathy, celiac associated with various extraintestinal manifestations, including neurologic complications such as neuropathy, ataxia, seizures, neurobehavioral changes. The cause manifestations unknown, but autoimmunity resulting from molecular mimicry between nervous system has been proposed play a...
Abstract Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into blood during systemic inflammatory conditions. We investigated organ dysfunction associated with changing serum SDC-1 levels for early detection of critically ill patients. To evaluate effect on laboratory parameters measured day after measurement consideration repeated measures, linear mixed effects models were constructed each parameter as an outcome variable. A total 94 patients enrolled, 831 samples...
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by glycocalyx injury. We aimed evaluate measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled this were 1313 who underwent examinations Hospital from January 2018 June 2018. One patient undergoing hemodialysis excluded the study....
Glycocalyx is present on the surface of healthy endothelium, and concentration serum syndecan-1 can serve as an injury marker. This study aimed to assess endothelial using a marker glycocalyx in patients who underwent hemodialysis. In this single-center, retrospective, observational study, 145 hemodialysis at Gifu University Hospital between March 2017 December 2019 were enrolled. The median dialysis period time 63 months 3.7 h, respectively. significantly increased from 124.6 ± 107.8 ng/ml...
Abstract To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH to Gifu University Hospital between April 2013 and March 2020. We analyzed CRYO on fluid balance 24 h after initial examination using a multivariable linear regression model adjusted several confounding variables. whether outcomes were modified by active bleeding, an interaction term CRYO*active bleeding...
Metformin-associated lactic acidosis is a well-known life-threatening complication of metformin. We here report the case patient who developed metformin-associated without organ manifestations, due to simultaneous ingestion an overdose metformin and alcohol, recovered with high-flow high-volume intermittent hemodiafiltration. A 44-year-old Asian woman type 2 diabetes attempted suicide by ingesting 10 tablets 500 mg drinking approximately 600 mL Japanese sake containing 15% alcohol. She was...
Myocardial dysfunction occurs in patients with sepsis due to vascular endothelial injury. Recombinant human thrombomodulin (rhTM) attenuates injuries through glycocalyx (eGC) protection.We hypothesized that rhTM myocardial via the inhibition of injury during sepsis.Ten-week-old male C57BL6 mice were injected intraperitoneally 20 mg/kg lipopolysaccharide (LPS). In rhTM-treated mice, was at 3 and 24 h after LPS injection. Saline as control. To assess for eGC injury, intensity score measured 48...
Heat-related illnesses include symptoms such as heat syncope/cramps, exhaustion, and life-threatening stroke. Usually, a stroke causes cerebellar ataxia, cognitive impairment, dysphagia, aphasia. We report very rare case of patient who developed severe complicated by multiple cerebral infarctions.An 80-year-old Asian woman was found lying unconscious at her house, with no air conditioner closed windows; the highest outside temperature 36.1 °C. She brought to our hospital high bladder (42.5...
Thyrotoxic crisis and pheochromocytoma multisystem are rare, life-threatening, emergency endocrine diseases with various clinical manifestations. Here we report a case of patient who simultaneously developed thyrotoxic required intensive cardiovascular management.A 60-year-old Asian man experienced nausea vomiting, subsequently dyspnea cold sweats while farming. His serum free thyroxine, triiodothyronine, thyrotropin receptor antibody levels were elevated at 2.9 ng/dL, 7.2 pg/dL, 4.7 IU/L,...
Leriche syndrome is caused by atherosclerosis and often characterized symptoms such as intermittent claudication numbness coldness of the lower limbs. Its exact prevalence incidence are unknown because it a rare disease. We report case diagnosed incidentally on trauma pan-scan computed tomography (CT).
Abstract Background Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair vascular endothelial-protection properties. Herein, we investigated whether rAT therapy beneficial effects against rhabdomyolysis-induced AKI. Ten-week-old male B6 mice were injected with 5 mL/kg 50% glycerol intramuscularly left thigh after 24 h fasting to create a rhabdomyolysis mouse model....
<title>Abstract</title> Background Compartment syndrome commonly occurs in patients with forearm and lower leg fractures. syndromes of the gluteal thigh muscles are less common. It is imperative that compartment be diagnosed treated fasciotomy as soon possible. However, there few reports on diagnosis treatment strategies for occur simultaneously multiple anatomical regions or ipsilateral region thigh. Case presentation: We report a 76-year-old man who was obliquely crushed under tree...
Abstract Background Compartment syndrome commonly occurs in patients with forearm and lower leg fractures. syndromes of the gluteal thigh muscles are less common. It is imperative that compartment be diagnosed treated fasciotomy as soon possible. However, there few reports on diagnosis treatment strategies for occur simultaneously multiple anatomical regions or ipsilateral region thigh. Case presentation We report a 76-year-old man who was obliquely crushed under tree extending from right to...
Infective endocarditis is a life-threatening disease and the early diagnosis crucial for better outcome. We report an old adult who developed infective in association with new-onset maxillary sinusitis as well proptosis, which was caused by orbital mass lesion background of pre-existing vascular malformation. A 74-year-old woman found incidentally to have right (venous) malformation head magnetic resonance imaging when she hospitalized left dorsal pontine infarction. No paranasal noted at...
Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome occurs in pregnant postpartum individuals. We observed serum syndecan-1 (SDC-1) levels, which is a component of the glycocalyx, patient with HELLP from admission to period examined their association as reflecting pathophysiology related endothelial injury.A 31-year-old primiparous female without previous medical history at gestational age 37 weeks 6 days was transferred our hospital morning after visit headache nausea....
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by glycocalyx injury. We aimed evaluate measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled this were 1313 who underwent examinations Hospital from January 2018, June 2018. One patient undergoing hemodialysis excluded the study....
Neurogenic acute respiratory failure is usually caused by either infection or vascular insufficiency. We report the case of a patient who developed secondary to spinal tumor.A 32-year-old man, presenting with numbness and muscle weakness in his legs for 2 weeks, was transferred our hospital worsening quadriplegia development symptoms. carried out emergent decompression initiated steroid pulse therapy, no resolution symptoms; tumor incision biopsy after contrast cervical magnetic resonance...
Abstract Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into blood during systemic inflammatory conditions. We examined organ dysfunction associated with changing serum SDC-1 levels critically ill patients. A single-center, retrospective, observational study was conducted at Gifu University Hospital. Patients admitted to intensive care unit from March 2019 February 2020 were enrolled. To evaluate effect of on laboratory parameters measured day after measurement...
Cardiac trauma is associated with a much higher mortality rate than injuries to other organ systems, even though cardiac identified in less 10% of all admissions. Here we report blunt the left atrium due snowboarding trauma. A 45-year-old Asian man collided tree while he was and drinking. He lost consciousness temporarily. An air ambulance requested transported an advanced critical care center. On arrival, pericardial effusion detected by focused assessment sonography for His presenting...