A5088667931- Nuclear Physics and Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Radiation Detection and Scintillator Technologies
- Fuel Cells and Related Materials
- Sepsis Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Cardiac tumors and thrombi
- Nuclear reactor physics and engineering
- Nuclear Materials and Properties
- Advanced Chemical Sensor Technologies
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Acute Kidney Injury Research
- Traumatic Ocular and Foreign Body Injuries
- Ion-surface interactions and analysis
- Vector-borne infectious diseases
- Hemodynamic Monitoring and Therapy
- Fusion materials and technologies
- Vascular Procedures and Complications
- Renin-Angiotensin System Studies
- Peripheral Artery Disease Management
- Trauma Management and Diagnosis
- Cardiac Arrest and Resuscitation
- Dark Matter and Cosmic Phenomena
Kyoto University
2025
Gifu University
2015-2024
Gifu University Hospital
2015-2022
Gifu Municipal Hospital
2022
Chibune General Hospital
2020
Nagano Children's Hospital
2016-2019
Japan Atomic Energy Agency
2004-2015
Advanced Science Research Center
2013
University of Wisconsin System
2010
Kameda Medical Center
1998
Abstract Syndecan-1 (SDC-1) is found in the endothelial glycocalyx and shed into blood during systemic inflammatory conditions. We investigated organ dysfunction associated with changing serum SDC-1 levels for early detection of critically ill patients. To evaluate effect on laboratory parameters measured day after measurement consideration repeated measures, linear mixed effects models were constructed each parameter as an outcome variable. A total 94 patients enrolled, 831 samples...
Abstract Background The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of glycocalyx, may reflect the disease state COVID-19 related to Case presentation A patient was transferred intensive care unit our hospital. Computed tomography chest showed bilateral ground glass opacities, which diagnosed as acute respiratory syndrome. PaO 2 /F I O ratio gradually increased from 158 on hospitalization 300 Day 11,...
Introduction Acute kidney injury (AKI), with a fatality rate of 8.6%, is one the most common types multiorgan failure in intensive care unit (ICU). Thus, AKI should be diagnosed early, and early interventions implemented. Urinary liver-type fatty acid-binding protein (L-FABP) could aid diagnosis AKI. Methods In this prospective, single-center, observational study, we included 100 patients trauma. L-FABP levels were measured using semi-quantitative rapid assay kit 6 12 h after injury....
Tissue injury and hemorrhage induced by trauma lead to degradation of the endothelial glycocalyx, causing syndecan-1 (SDC-1) be shed into blood. In this study, we investigated whether serum SDC-1 is useful for evaluating severity in patients. A single-center, retrospective, observational study was conducted at Gifu University Hospital. Patients transported emergency room subsequently admitted intensive care unit from January 2019 December 2021 were enrolled. linear regression model...
Development of neurological complications varicella zoster virus reactivation is relatively uncommon, particularly in an immunocompetent child. An 11-year-old Asian girl presented with headache and skin rash on her left chest. She was diagnosed meningitis, herpes confirmed by polymerase chain reaction using cerebrospinal fluid. Acyclovir administered intravenously. Given the favorable evolution clinical course, she discharged from hospital day 8 illness. had no apparent sequelae or...
Glycocalyx is present on the surface of healthy endothelium, and concentration serum syndecan-1 can serve as an injury marker. This study aimed to assess endothelial using a marker glycocalyx in patients who underwent hemodialysis. In this single-center, retrospective, observational study, 145 hemodialysis at Gifu University Hospital between March 2017 December 2019 were enrolled. The median dialysis period time 63 months 3.7 h, respectively. significantly increased from 124.6 ± 107.8 ng/ml...
Cerebral fat embolism (CFE) is a rare syndrome caused by the embolization of particles into brain circulation. This prospective single-center observational study investigated incidence CFE in long-bone or pelvic fractures based on magnetic resonance imaging (MRI) findings. The purpose this was to investigate MRI findings with without symptoms suggestive CFE.Eligible patients were consecutive, aged 15 years older, high-energy traumas, including femur fractures. Excluded those who died, could...
This paper describes an overview of our recent discovery – clear demonstration that LiF crystals can be efficiently used as a high-performance neutron imaging detector based on optically stimulated luminescence color centers generated by irradiation. It is shown the images we have obtained are almost free from granular noise, spatial resolution ${\sim}5.4~{\rm\mu}\text{m}$ and linear response with dynamic range at least $10^{3}$ . The high contrast good sensitivity allow us to distinguish...
Abstract To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH to Gifu University Hospital between April 2013 and March 2020. We analyzed CRYO on fluid balance 24 h after initial examination using a multivariable linear regression model adjusted several confounding variables. whether outcomes were modified by active bleeding, an interaction term CRYO*active bleeding...
Syndecan-1 is found in the endothelial glycocalyx and released into bloodstream during stressed conditions, including severe diseases such as acute kidney injury, chronic disease, cardiovascular disease. This study investigated prognostic value of serum syndecan-1 concentration patients with heart failure upon admission. Serum was analyzed 152 who were hospitalized for worsening from September 2017 to June 2018. The primary outcome readmission-free survival, defined time first admission...
Advanced neutron radiography techniques such as the imaging plate (NIP) and computed tomography (NCT) methods have been investigated in practicability for postirradiation examination (PIE). In current works, an unirradiated fuel rod was examined by NIP NCT order to collect fundamental data applying these PIE. A used is composed of seven-enriched UO/sub 2/ two-natural pellets with controlled sizes shape that are loaded into a Zircaloy tube. The tests were performed at 2nd Thermal Neutron...
Metformin-associated lactic acidosis is a well-known life-threatening complication of metformin. We here report the case patient who developed metformin-associated without organ manifestations, due to simultaneous ingestion an overdose metformin and alcohol, recovered with high-flow high-volume intermittent hemodiafiltration. A 44-year-old Asian woman type 2 diabetes attempted suicide by ingesting 10 tablets 500 mg drinking approximately 600 mL Japanese sake containing 15% alcohol. She was...
In the spring of 2015, we experienced a cluster 4 sporadic cases yersiniosis in children Nagano prefecture, rural area Japan. Two patients developed appendicitis-like episodes; one had acute gastroenteritis, and other bacteremia associated with liver abscess. The causative agent these infections was Yersinia enterocolitica serogroup O:8. None an underlying illness, all have recovered completely. were neither socially nor geographically related to each other. These consecutive suggest that Y....
Myocardial dysfunction occurs in patients with sepsis due to vascular endothelial injury. Recombinant human thrombomodulin (rhTM) attenuates injuries through glycocalyx (eGC) protection.We hypothesized that rhTM myocardial via the inhibition of injury during sepsis.Ten-week-old male C57BL6 mice were injected intraperitoneally 20 mg/kg lipopolysaccharide (LPS). In rhTM-treated mice, was at 3 and 24 h after LPS injection. Saline as control. To assess for eGC injury, intensity score measured 48...
Heat-related illnesses include symptoms such as heat syncope/cramps, exhaustion, and life-threatening stroke. Usually, a stroke causes cerebellar ataxia, cognitive impairment, dysphagia, aphasia. We report very rare case of patient who developed severe complicated by multiple cerebral infarctions.An 80-year-old Asian woman was found lying unconscious at her house, with no air conditioner closed windows; the highest outside temperature 36.1 °C. She brought to our hospital high bladder (42.5...