A5086956470- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Lipid metabolism and biosynthesis
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Clinical Nutrition and Gastroenterology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac pacing and defibrillation studies
- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Atrial Fibrillation Management and Outcomes
- Kruppel-like factors research
- S100 Proteins and Annexins
- Tea Polyphenols and Effects
- Andrographolide Research and Applications
- Pharmacological Effects of Natural Compounds
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- Oral health in cancer treatment
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
Ankang City Central Hospital
2025
Central South University of Forestry and Technology
2024
Central South University
2024
Shanghai University of Traditional Chinese Medicine
2018-2024
Anhui Provincial Hospital
2023
University of Science and Technology of China
2023
Hangzhou First People's Hospital
2022
Zhejiang University
2022
State Key Laboratory of Genetic Engineering
2018
Fudan University
2018
Abstract Background Esophageal squamous cell carcinoma (ESCA) is a type of cancer that starts in the cells lining esophagus, tube connecting throat to stomach. It known for its aggressive nature and poor prognosis. Understanding key factors drive this crucial developing better diagnostic tools treatments. Methods Gene expression profiles ESCA were analyzed using Expression Omnibus (GEO) datasets (GSE23400, GSE29001, GSE92396, GSE1420) from GEO database. Differentially expressed genes (DEGs)...
The roles of exonuclease 1 (EXO1) in hepatocellular carcinoma (HCC) tumorigenesis and progression remain unclear. This study aimed to assess the prognostic value therapeutic potential EXO1 HCC. Exo1 gene copy numbers were obtained from three Oncomine microarray datasets (n = 447). mRNA expression was validated by semi-quantitative PCR QuantiGene® 2.0 assays. Cell growth curve colony formation performed asses cell proliferation. Clonogenic assay, flow cytometry, immunofluorescence adopted...
The roles of nonsteroidal anti-inflammatory drugs (NSAIDs) in the occurrence and prognosis hepatocellular carcinoma (HCC) remain controversial. This analysis aimed to summarize relationships between NSAIDs HCC development.Studies published prior October 1, 2017, PubMed, Embase, Ovid, Web Science, Cochrane Library databases were systematically searched analyzed.Eleven studies included this analysis. A meta-analysis five revealed that aspirin use could significantly decrease risk (hazards...
Camellia oil is valuable as an edible and serves a base material for range of high-value products. plants significant economic importance, such sinensis oleifera, have been classified into sect. Thea Oleifera, respectively. Fatty acid desaturases play crucial role in catalyzing the formation double bonds at specific positions fatty chains, leading to production unsaturated acids contributing lipid synthesis. Comparative genomics results revealed that expanded gene families tea are enriched...
Recent studies have shown that Toll-like receptors (TLRs) may be associated with cancers. The aim of this meta-analysis is to summarize the predicting role TLRs for survival in patients a variety carcinomas.Eligible were identified and assessed quality through multiple search strategies. We collected data from investigating relationship between expression level cancer patients. Studies pooled combined hazard ratios (HRs) analyzed.A total 24 studies, including 2,812 various cancers,...
DNA hydroxymethylation is one of the major epigenetic mechanisms mediating development several human cancers. This study aimed to identify key hydroxymethylated genes and transcription factors (TFs) associated with alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) using whole-genome profiling. A total 615 differentially regions (DHMRs) were identified from AFP-negative HCC tissues compared adjacent normal tissues. DHMR-associated significantly enriched in gene ontology...
Tumor angiogenesis is one of the hallmarks cancer as well an attractive target for therapy. Characterization novel pathways that act in parallel with VEGF/VEGFR axis to promote tumor may provide insights into anti-angiogenic therapeutic targets. We found expression level Nogo-B positively correlated vessel density hepatocellular carcinoma (HCC). While depletion inhibited angiogenesis, overexpression promoted a xenograft subcutaneous model human HCC cell line. Mechanically, regulates based on...
Background: Colorectal Cancer (CRC) is one of the top three malignancies with highest incidence and mortality. Objective: The study aimed to identify effect Traditional Chinese Medicine (TCM) on postoperative patients stage II-III CRC explore core herb combination its mechanism. Methods: An observational cohort was conducted diagnosed from January 2016 2021. primary outcome disease-free survival, which compared between who received TCM or not, secondary hazard ratio. relevance principle used...
Abstract Objective This is a retrospective observational cohort study. The objective of this study was to evaluate the value combined serum d -lactic acid, diamine oxidase (DAO), and endotoxin levels predict intestinal barrier impairment gut-derived infection (GDI) in cancer patients. Methods Cancer patients receiving chemotherapy or palliative care treatment at our hospital were enrolled concentrations DAO, determined using function biochemical index analysis system. patients' information...
Internal cardioversion (ICV) and external (ECV) are two commonly used methods of electrocardioversion; however, the optimal method for treatment atrial fibrillation (AF) is yet unknown. This systematic review evaluates compares safety efficacy ICV ECV with AF through a meta-analysis. Systematic reviews were retrieved from Medline, PubMed, Embase, Cochrane libraries, ScienceDirect databases. All clinical trials comparing CV screened included if inclusion criteria fulfilled. Four trials,...