A5065903282- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Liver Disease and Transplantation
- Mechanical Circulatory Support Devices
- Frailty in Older Adults
- Bipolar Disorder and Treatment
- Gut microbiota and health
- Child and Adolescent Psychosocial and Emotional Development
- Pancreatic function and diabetes
- Hip and Femur Fractures
- Pectus Deformity Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Musicians’ Health and Performance
- History of Medicine Studies
- Congenital heart defects research
- Biotin and Related Studies
- Myasthenia Gravis and Thymoma
- Central Venous Catheters and Hemodialysis
- Biliary and Gastrointestinal Fistulas
- Ultrasound in Clinical Applications
- Developmental Biology and Gene Regulation
- Enhanced Recovery After Surgery
Washington University in St. Louis
2020-2024
University of Nebraska Medical Center
2018-2024
Oregon Health & Science University
2024
St. Louis Children's Hospital
2020-2023
University of Nebraska at Omaha
2020
Michigan State University
2015-2018
Corewell Health Blodgett Hospital
2018
Spectrum Health
2018
Helen DeVos Children's Hospital
2018
Grand Rapids Community College
2016
Surgical removal of the intestine, lifesaving in catastrophic gastrointestinal disorders infancy, can result a form intestinal failure known as short bowel syndrome (SBS). Bloodstream infections (BSIs) are major challenge pediatric SBS management. BSIs require frequent antibiotic therapy, with ill-defined consequences for gut microbiome and childhood health. Here, we combine serial stool collection, shotgun metagenomic sequencing, multivariate statistics genome-resolved strain-tracking...
In utero hematopoietic cell transplantation (IUHCT) utilizes fetal immune tolerance to achieve durable chimerism without conditioning or immunosuppression during a unique window in development. Though donor cells have been observed within the nervous system following injection, timeline and distribution of cellular trafficking across blood-brain barrier IUHCT is not well understood. We injected 20 × 106 adult bone marrow mononuclear intravenously at gestational age (GA) 12–17 days found that...
The unfolded protein response (UPR) is a complex adaptive signaling pathway activated by the accumulation of misfolded proteins in endoplasmic reticulum (ER). ER stress (ERS) triggers cascade responses that converge upon C/EBP homologous (CHOP) to drive inflammation and apoptosis. Herein, we sought determine whether liver injury fibrosis after small bowel resection (SBR) were mediated maladaptive hepatic ERS/UPR. C57BL/6 mice underwent 50% proximal SBR or sham operation. Markers UPR/ERS...
Unlike C57BL/6 mice, the 129S1/SvImJ strain is resistant to liver inflammation and injury after small bowel resection. These disparate outcomes are likely due accumulation of hepatic free fatty acids as well increased endotoxin-driven inflammatory pathways through PPARα TLR4 in mice with short syndrome.
Rampant autoimmune disease has the potential to ravage entirety of body in a systemic fashion. Rarely, it been reported for Takotsubo cardiomyopathy develop as result refractory inflammatory bowel disease. Balancing comprehensive cares required support both cardiovascular system and treat underlying condition care present unique challenges. Here, we describe patient who developed late-onset after prolonged stress uncontrolled Crohn's While this unfortunately did succumb process, is our hope...
Abstract Annular pancreas is a rare congenital abnormality that often considered neonatal condition, though in few cases it can present adulthood. Patients diagnosed with annular adulthood are asymptomatic and incidentally from radiologic studies. While there no existing treatment protocol for symptomatic pancreas, multiple surgical approaches have been documented the literature. In this case study we 49-year-old female patient who presented gastric outlet obstruction secondary to pancreas....
The nation's aging population presents novel perioperative challenges. Potential benefits of operative interventions must be scrutinized in relation to recoverable quality life. purpose this study is evaluate common risk calculators used for medical decision making a nonagenarian patient population.
After 50% proximal small bowel resection (SBR) in mice, we have demonstrated hepatic steatosis, impaired glucose metabolism without insulin resistance, and increased pancreatic islet area. We sought to determine the consequences of SBR on β-cell morphology, proliferation, expression a key regulatory hormone, glucagon-like peptide-1 (GLP-1). C57BL/6 mice underwent or sham operation. At 10 wk, content secretion was measured by ELISA. Immunohistochemistry performed structural alterations α-and...
Introduction: Ischemic stroke patients who arrive by emergency medical service (EMS) receive faster department evaluations and improved rates of thrombolytic treatment. However, EMS recognition compliance with prehospital quality measures are inconsistent. We hypothesized that care is influenced a complex interaction knowledge, beliefs, system-level variables influence behavior. Methods: Focus groups paramedics from single urban/suburban county were assembled to discuss their experiences...
Congenital malrotation is a pathology nearly exclusive to the infant population. In rare instance when it diagnosed in an adult, typically associated with longstanding history of gastrointestinal symptoms. Unfortunately, this unique presentation unexpected population has potential be confounding, leading delayed or mismanaged care. Here, we describe intriguing case congenital complicated by midgut volvulus 68-year-old woman. Even more curious, patient did not have medical plagued abdominal...
Major limb amputation can be the unfortunate consequence of nonreconstructable peripheral arterial disease and chronic threatening ischemia. Phantom pain (PLP) neuroma-associated remain significant challenges for many specialists who treat patients after major amputations. PLP is perception discomfort in no longer present.1Valerio I.L. Dumanian G.A. Jordan S.W. Mioton L.M. Bowen J.B. West J.M. Potter B.K. Preemptive treatment phantom residual with targeted muscle reinnervation at time...
Introduction: Pectus Excavatum (PEX) is the most common anterior chest wall deformity. While minimally invasive repair of pectus excavatum (MIRPE) has improved perioperative outcomes, there continue to be opportunities optimize postoperative pain management and reduce length stay (LOS). We compared impact a multimodal expedited protocol utilizing combination systemic regional analgesia (with single shot paravertebral truncal blocks), along with coping techniques (such as meditation),...
Purpose To concisely present recommendations and guidelines for venous thromboembolism (VTE) treatment prevention common subgroups of surgical patients as a comprehensive reference clinical practice.Methods Thorough literature review, including the consensus various professional societies, was evaluated conglomerated to provide practicing surgeons. Common patient were investigated differing recommendations. Recommendations, guidelines, resources tabulated into user-friendly formats easy...