A5002845612- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Infant Nutrition and Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Liver Disease Diagnosis and Treatment
- Healthcare professionals’ stress and burnout
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Trauma and Emergency Care Studies
- Intestinal Malrotation and Obstruction Disorders
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Perfectionism, Procrastination, Anxiety Studies
- Polyamine Metabolism and Applications
- Gallbladder and Bile Duct Disorders
- Ginger and Zingiberaceae research
- Infant Development and Preterm Care
- Health Literacy and Information Accessibility
- Pericarditis and Cardiac Tamponade
- Mast cells and histamine
Baylor College of Medicine
2022-2025
Washington University in St. Louis
2016-2023
Barnes-Jewish Hospital
2023
Jewish Hospital
2023
St. Louis Children's Hospital
2016-2020
Korea Advanced Institute of Science and Technology
2017
Texas Medical Center
1995
Medical Center Hospital
1995
Oregon Health & Science University
1984
Quality could be augmented with broader explanations of complications and alternative options.
Background & AimsIntestinal adaptation is a compensatory response to the massive loss of small intestine after surgical resection. We investigated role intestinal epithelial cell–specific mammalian target rapamycin complex 1 (i-mTORC1) in bowel resection (SBR).MethodsWe performed 50% proximal SBR on mice study adaptation. To manipulate i-mTORC1 activity, Villin-CreER transgenic were crossed with tuberous sclerosis (TSC)1flox/flox or Raptorflox/flox inducibly activate inactivate activity...
Liver fatty acid binding protein (L-Fabp) modulates lipid trafficking in enterocytes, hepatocytes, and hepatic stellate cells (HSCs). We examined hepatocyte vs. HSC L-Fabp deletion metabolic adaptation fibrotic injury. Floxed mice were bred to different transgenic Cre or injected with adeno-associated virus type 8 (AAV8) fed diets promote steatosis fibrosis subjected either bile duct ligation CCl4 Albumin-Cre-mediated revealed recombination hepatocytes HSCs; these findings confirmed 2 other...
Between April 1, 1989, and January 1994, 38 patients with chronic acalculous cholecystitis underwent an advanced (3-puncture) laparoscopic cholecystectomy at our institution. The 30 women 8 men had a mean age of 39 years (range, 23 to 65 years) represented 4.5% overall gallbladder patient population. In each case, the disease produced typical biliary colic, but no gallstones were visualized on ultrasound examination; cholecystokinin-stimulated cholescintigraphy revealed dysfunctional...
Abstract Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and source IL-25, a critical initiator type 2 immune response to parasite infection. When Raptor, scaffold protein for mammalian target rapamycin complex 1 (mTORC1), was acutely deleted intestinal epithelium via Tamoxifen injection Tritrichomonas muris (Tm) infected mice, cells, IL-25 IL-13 mesenchyme were significantly reduced, but Tm burden not affected. mice treated with rapamycin, DCLK1 expression...
Operative mortality and morbidity for coronary artery bypass graft (CABG) surgery has decreased in recent years, but not women.1 rates CABG female patients are consistently higher than they male patients.1,2 This finding appears to have multiple contributors. Timely diagnosis of disease (CAD) women is lacking, the patient's average condition at presentation demonstrates this: Women diagnosed with CAD 7 10 years older men CAD3; more comorbid conditions, such as diabetes, hypertension,...
This study sought to determine the feasibility of collecting physiologic data in thoracic surgery residents and whether it would correlate with burnout performance.This was a prospective over 5-month period. Participants were evaluated wearable biometric device (heart rate variability sleep) Maslach Burnout Inventory. Resident performance quantified using Accreditation Council for Graduate Medical Education Milestones (scale, 1-5) normalized program-designated targets (3 postgraduate year 6...
Mammalian target of rapamycin complex 1 (mTORC1) is a major regulator cell growth and proliferation through fuel sensing. Systemic inhibition mTOR as well manipulation its downstream products prevent diet-induced obesity. The purpose this study was to determine the consequences intestine-targeted mTORC1 inhibition. To attenuate intestinal activity, Villin-CreER mice were crossed with Raptorflox/flox mice, creating an intestinal-specific Raptor null line (i-Raptor −/−). Mice fed high fat diet...
After 50% proximal small bowel resection (SBR) in mice, we have demonstrated hepatic steatosis, impaired glucose metabolism without insulin resistance, and increased pancreatic islet area. We sought to determine the consequences of SBR on β-cell morphology, proliferation, expression a key regulatory hormone, glucagon-like peptide-1 (GLP-1). C57BL/6 mice underwent or sham operation. At 10 wk, content secretion was measured by ELISA. Immunohistochemistry performed structural alterations α-and...