A5082394547- RNA modifications and cancer
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Aquaculture Nutrition and Growth
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Pancreatic function and diabetes
- Hepatitis B Virus Studies
- Atherosclerosis and Cardiovascular Diseases
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Vibrio bacteria research studies
- T-cell and B-cell Immunology
- FOXO transcription factor regulation
- Phagocytosis and Immune Regulation
- Toxin Mechanisms and Immunotoxins
- Crustacean biology and ecology
- Physiological and biochemical adaptations
- Pomegranate: compositions and health benefits
- Peptidase Inhibition and Analysis
- Bioactive Compounds in Plants
- Diet, Metabolism, and Disease
Fujian Agriculture and Forestry University
2024-2025
Shandong University
2020-2024
Jackson Laboratory
2024
Resistance to PD-1 blockade in onco-immunotherapy greatly limits its clinical application. T cell immunoglobulin and mucin domain containing-3 (Tim-3), a promising immune checkpoint target, is cleaved by ADAM10/17 produce soluble form (sTim-3) humans, potentially becoming involved anti-PD-1 resistance. Herein, serum sTim-3 upregulation was observed non-small lung cancer (NSCLC) various digestive tumors. Notably, further upregulated non-responding patients undergoing therapy for NSCLC...
Abstract According to the latest evidence, microbial metabolite Urolithin A (UA), known for its role in promoting cellular health, modulates CD8 + T cell‐mediated antitumor activity. However, direct target protein of UA and underlying mechanism remains unclear. Here, this research identifies ERK1/2 as specific crucial UA‐mediated cell activation. Even at low doses, markedly enhances persistence effector functions primary cytotoxic lymphocytes (CTLs) human chimeric antigen receptor (CAR)...
Abstract Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in nucleus resistant antiviral agents. Identification factors involved cccDNA regulation expected prove a new venue for HBV therapy. Recent evidence suggests involvement long noncoding RNAs (lncRNAs) mediating interaction various viruses, however, lncRNAs that targets represses transcription have not been fully...
T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), expressed in dysfunctional exhausted cells, has been widely acknowledged as a promising immune checkpoint target for tumor immunotherapy. Here, using strategy combining virtual functional screening, we identified compound named ML-T7 that targets the FG-CC′ cleft of Tim-3, highly conserved binding site phosphatidylserine (PtdSer) carcinoembryonic antigen–related adhesion 1 (CEACAM1). enhanced survival antitumor activity primary...
Abstract Hepatocellular carcinoma (HCC) is one of the leading causes cancer‐related death worldwide. Lipogenesis has been considered as a critical player in HCC initiation and progression. However, underlying mechanism still not fully understood. Here, we identified zinc fingers homeoboxes 2 (ZHX2), an HCC‐associated tumor suppressor, important repressor de novo lipogenesis. Ectopic expression ZHX2 significantly inhibited lipogenesis cells decreased FASN, ACL, ACC1, SCD1. In accordance with...
Four experimental diets containing 45% crude protein and 11% lipid were formulated by replacing total fish oil (FO) with poultry (PO), beef tallow (BT) lard (LO) to evaluate the effects of terrestrial animal fats (TAFs) dietary FO in juvenile green mud crabs (Scylla paramamosain). A 120 female juveniles (initial body weight 43.23 ± 0.21 g) was randomly assigned four diet (three replicates per diet) stocked into single crab cells (0.23 m × 0.15 0.33 m, width height length) circulating...
Macrophages display functional phenotypic plasticity. Hepatitis B virus (HBV) infection induces polarizations of liver macrophages either to M1-like pro-inflammatory phenotype or M2-like anti-inflammatory phenotype. Gamma-aminobutyric acid (GABA) signaling exists in various non-neuronal cells including hepatocytes and some immune cells. Here we report that express GABAergic components activation type A GABA receptors (GABAARs) promotes M2-polarization thus advancing HBV replication. Notably,...
Emerging evidence shows that pancreatic β-cell function and quality are key determinants in the progression of type 2 diabetes (T2D). The transcription factor zinc finger homeobox (Zhx2) is involved proliferation development multiple cells. However, exact role Zhx2 β-cells T2D remains completely unknown. Here, we report orchestrates mass by regulating paired box protein pax-6 (Pax6). We found β-cell-specific knockout (Zhx2BKO) mice showed a decrease glucose homeostasis. Under prediabetic...
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide. Lipogenesis has been considered as a critical player in HCC initiation and progression. However, underlying mechanism still not fully understood. METHODS: ZHX2 overexpression knockdown were introduced into cell lines. BODIPY staining D-Glucose- 13C6 labeled lipid mass spectrometry involved to estimate lipogenesis Colony formation proliferation assays used determine development. Hepatocytes...