A5082277678- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Infectious Encephalopathies and Encephalitis
- Autoimmune Neurological Disorders and Treatments
- Blind Source Separation Techniques
- Neonatal and fetal brain pathology
- RNA Research and Splicing
- Vascular Malformations Diagnosis and Treatment
- Syphilis Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Elevator Systems and Control
- Magnesium in Health and Disease
- Currency Recognition and Detection
- Peripheral Neuropathies and Disorders
- Virology and Viral Diseases
- ECG Monitoring and Analysis
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Bacterial Infections and Vaccines
- Advanced Battery Technologies Research
- Meningioma and schwannoma management
Shandong University
2023-2024
Jinan Maternity And Care Hospital
2023
Qilu Hospital of Shandong University
2008-2022
The LAMA5 gene encodes the laminin subunit α5, most abundant α in human brain. It forms heterotrimers with β1/β2 and γ1/γ3 regulates neurodevelopmental processes. Genes encoding subunits of containing α5 have been reported to be associated diseases. Among LAMAs subunit, LAMA1-4 also disease. In this study, we investigated association between epilepsy.Trios-based whole-exome sequencing was performed a cohort 118 infants suffering from focal seizures or without spasms. Protein modeling used...
To examine the clinical effectiveness and tolerability of perampanel (PER) as initial monotherapy in pediatric patients with newly diagnosed focal epilepsy.A retrospective analysis was conducted on 62 children epilepsy who were treated PER at Epilepsy Center Jinan Children's Hospital from July 2021 to 2022. The treatment status, prognosis, adverse reactions followed up for a minimum 6 months after initiation monotherapy. estimated by effective rate 3-, 6-, 12-month follow-up evaluations also...
We designed this study to investigate the effects of coronavirus disease 2019 (COVID-19) vaccine on epileptic seizures, as well its adverse effects, in children with epilepsy (<18 years).
Several COVID-19 vaccines list "uncontrolled epilepsy" as a contraindication for vaccination. This consequently restricts vaccination against in patients with epilepsy (PWE). However, there is no strong evidence that can exacerbate conditions PWE. study aims to determine the impact of on PWE were prospectively recruited from 25 centers. We recorded seizure frequency at three time periods (one month before first and one after second vaccinations). A generalized linear mixed-effects model...
To investigate the clinical variables that might predict outcome of developmental and epileptic encephalopathy (DEE) after vagus nerve stimulation (VNS) therapy identify risk factors for poor long-term outcome.We retrospectively studied 32 consecutive children with drug-resistant DEE who had undergone VNS surgery from April 2019 to July 2021, which were not suitable corpus callosotomy. In spite combining valproic acid, levetiracetam, lamotrigine, topiramate, etc. (standard anti-seizure...
Abstract Objective. Electrical status epilepticus during slow sleep (ESES) is a phenomenon identified by strong activation of epileptiform activity in the electroencephalogram (EEG) sleep. For children disturbed ESES, spike-wave index (SWI) defined to quantify EEG Accurate SWI quantification important for clinical diagnosis and prognosis. To automatically, deep learning method proposed this paper. Approach. Firstly, pre-labeling algorithm (PreLA) composed adaptive wavelet enhanced...
Abstract Background Leucine-rich glioma-inactivated protein 1 (LGI1) antibody-mediated encephalitis is a rare subtype of autoimmune encephalopathy, which associated with autoimmunity against the neuronal plasma membrane proteins. The characteristic symptoms this disease are memory dysfunction, seizures, faciobrachial dystonic cognitive deficits, neuropsychiatric disturbances, and intractable hyponatremia. diagnosis mainly depends on presence anti-LGI1 antibody in serum or cerebrospinal fluid...
The electroencephalogram (EEG) exhibits characteristics of complexity and strong randomness. Existing deep learning models for EEG typically target specific objectives datasets, with their scalability constrained by the size dataset, resulting in limited perceptual generalization abilities. In order to obtain more intuitive, concise, useful representations brain activity, we constructed a reconstruction-based self-supervised model based on Variational Autoencoder (VAE) separate frequency...
Epilepsy patients experience challenges in daily life, and epilepsy seizures might cause injuries or endanger the life of others. The electroencephalogram (EEG) signals, recorded by a machine device, are often used to analyze brain electrical activity, which is noninvasive. Locating seizure period EEG recordings usually difficult time consuming for doctors. Therefore, automatic detection necessary. In this paper, we use autocorrelation function extract features, propose method based on...
To explore the genetic etiology of a child with Hypomagnesemia, epilepsy and mental retardation syndrome (HSMR).A who was admitted to Children's Hospital Shandong University on July 9, 2021 due repeated convulsions for 2 months selected as study subject. Clinical data collected. Peripheral blood samples his pedigree members were collected extraction genomic DNA. Whole exome sequencing carried out, candidate variant verified by Sanger bioinformatic analysis.The child, 1-year-and-7-month-old...
To investigate the clinical and genetic features of a Chinese girl featuring mental retardation, intellectual disability, language development delay epilepsy.G-banded chromosomal karyotyping was carried out for child. Genomic DNA patient her parents extracted subjected to high-throughput sequencing. The results were analyzed with bioinformatic tools validated by Sanger sequencing.The karyotype child ascertained as 46,XX. Sequencing result showed that she has de novo heterozygous c.1861C>T...
Abstract Objective. Electrical status epilepticus during slow sleep (ESES) is a phenomenon identified by strong activation of epileptiform activity in the electroencephalogram (EEG) sleep. For children disturbed ESES, spike-wave index (SWI) defined to quantify EEG Accurate SWI quantification important for clinical diagnosis and prognosis. To automatically, deep learning method proposed this paper. Approach. Firstly, pre-labeling algorithm (PreLA) composed adaptive wavelet enhanced...
To explore the genetic basis for a Chinese boy featuring developmental delay and epilepsy.Clinical data of patient was collected. Genomic DNA his parents extracted subjected to high-throughput sequencing. Pathogenicity variant predicted validated.Sequencing results showed that has carried de novo c.1470delA (p.V491Ffs*6) UBE3A gene, which be pathogenic.The frameshift probably underlay disorders in this child.
Objective. To analyze the EEG features of four subacute sclerosing panencephalitis cases in North China. Methods. We retrospectively analyzed patients with and 12 control group from Results. The periodic long-interval diffuse discharges were found all panencephalitis. morphology component complexes varied different wakefulness states. Some parameter settings help to identify including slowed sweep speed, decreased sensitivity reduced number montages. In each patient panencephalitis,...