A5064851939- Hematopoietic Stem Cell Transplantation
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Cancer-related gene regulation
- Plant-Microbe Interactions and Immunity
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Probiotics and Fermented Foods
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Essential Oils and Antimicrobial Activity
- Genetic Syndromes and Imprinting
- Synthesis and biological activity
- Dietary Effects on Health
- Biochemical and Structural Characterization
- Axon Guidance and Neuronal Signaling
- Bioactive Natural Diterpenoids Research
- Phytochemicals and Antioxidant Activities
- Hippo pathway signaling and YAP/TAZ
- Escherichia coli research studies
- Ovarian cancer diagnosis and treatment
Lund University
2001-2024
International Peace Maternity & Child Health Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
China Agricultural University
2024
Nanjing University of Chinese Medicine
2024
Guizhou University
2019-2023
TU Dresden
2017-2021
Guilin Medical University
2021
Hubei University of Chinese Medicine
2021
University of Chinese Academy of Sciences
2020
Bacterial metabolites exhibit a variety of biologically active compounds including antibacterial and antifungal activities. It is well known that Bacillus considered to be promising source bioactive secondary metabolites. Most plant pathogens have an incredible ability mutate acquire resistance, causing major economic losses in the agricultural field. Therefore, it necessary use natural microbes control pathogens. This study was conducted investigate bio-active megaterium L2. According...
The intestinal mucus barrier is an important line of defense against gut pathogens. Damage to this brings bacteria into close contact with the epithelium, leading inflammation. Therefore, its restoration a promising strategy for alleviating This study showed that
Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem (HSC) function contribute to this, the vivo dynamics of such changes remain obscure. Here, we integrate extensive longitudinal functional assessments HSC-specific lineage tracing single-cell transcriptome epitope profiling. In contrast recent suggestions from RNA sequencing alone, our data favor a defined structure HSC/progenitor differentiation...
Germ cell development involves major reprogramming of the epigenome to prime zygote for totipotency. Histone 3 lysine 4 (H3K4) methylations are universal epigenetic marks mediated in mammals by six H3K4 methyltransferases related fly Trithorax, including two yeast Set1 orthologs: Setd1a and Setd1b. Whereas plays no role oogenesis, we report that Setd1b deficiency causes female sterility mice. Oocyte-specific Gdf9-iCre conditional knockout (Setd1bGdf9 cKO) ovaries develop through all stages;...
The scarcity of hematopoietic stem cells (HSCs) restricts their use in both clinical settings and experimental research. Here, we examined a recently developed method for expanding rigorously purified murine HSCs ex vivo. After 3 weeks culture, only 0.1% exhibited the input HSC phenotype, but these accounted almost all functional long-term activity. Input displayed varying potential vivo self-renewal, with alternative outcomes revealed by single-cell multimodal RNA ATAC sequencing profiling....
Two Gram-negative, rod-shaped, gliding and pink-pigmented bacterial strains, X14-1T X19-1, were isolated from a mixture of sand samples collected the desert Xinjiang, China, characterized by using polyphasic taxonomic approach. Strains X19-1 contained MK-7 as predominant menaquinone. The major cellular fatty acids included iso-C15 : 0, iso-C17 0 3-OH, summed feature 3 4. DNA G+C contents strains 48.2 48.9 mol%, respectively. 16S rRNA gene sequence analysis showed that isolates highly related...
Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene. Here, we add to emerging evidence that all H3K4 play essential roles hematopoietic system by showing conditional mutagenesis Setd1b adult mice provoked aberrant homeostasis progenitor (HSPCs). Using both ubiquitous hematopoietic-specific deletion strategies, loss resulted peripheral thrombo- lymphocytopenia,...
Aspergillus fungi can produce a wide range of secondary metabolites, and they have represented potential resource novel bioactive compounds. Bacterial plant diseases serious impact on the sustainable development agriculture worldwide, so it is necessary to use natural antibacterial compounds in microorganisms control pathogens. This study was conducted investigate niger xj, three pathogens (Agrobacterium tumefaciens T-37, Erwinia carotovora EC-1, Ralstonia solanacearum RS-2) were used as...
Methylation of histone 3 lysine 4 (H3K4) is a major epigenetic system associated with gene expression. In mammals there are six H3K4 methyltransferases related to yeast Set1 and fly Trithorax, including two orthologs Trithorax-related: MLL3 MLL4. Exome sequencing has documented high frequencies
Background: The selectin family of adhesion molecules (P-, E- and L-selectin) plays an important role in inflammatory reactions by mediating interactions between leukocytes activated endothelial cells. However, a recent study using gene-targeted mice has suggested that (P- Eselectin ICAM-1) may not be relevant targets intestinal inflammation. objective the present was to re-evaluate potential selectins experimental colitis wild-type polysaccharide fucoidan, which inhibits function P-...
Abstract Infant and adult MLL1/KMT2A -rearranged (MLLr) leukemia represents a disease with dismal prognosis. Here, we present functional proteomic characterization of in utero -initiated adult-onset MLLr leukemia. We reveal that fetal MLL::ENL -expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards lymphoid fate but give rise to myeloid vivo, highlighting complex interplay intra- extracellular factors determining subtype. characterize early events...
The fetal-to-adult switch in hematopoietic stem cell (HSC) behavior is characterized by alterations lineage output and entry into deep quiescence. Here we identify the emergence of megakaryocyte (Mk)-biased HSCs as an event coinciding with this developmental switch. Single-cell chromatin accessibility analysis reveals a ubiquitous acquisition Mk priming signatures during transition. These molecular changes functionally coincide increased amplitude early differentiation events after acute...
Background: Hepatocellular carcinoma (HCC) cells exhibit the stemness property, which makes patient with HCC prone to tumor recurrence and metastasis. Despite prominent regulatory role of long non-coding RNAs (lncRNAs) in stemness, roles molecular mechanisms LINC00106 are poorly understood. Methods: LINC00106, let7f periostin expression levels tissue specimens cell lines were assessed through qRT-PCR immunohistochemistry (IHC). Various vivo vitro assays, namely sphere/colony formation,...
The scarcity of hematopoietic stem cells (HSCs) restricts their use in both clinical settings and experimental research. Here, we examined a recently developed method for expanding rigorously purified murine HSCs ex vivo. After 3 weeks culture, only 0.1% exhibited the input HSC phenotype, but these accounted almost all functional long-term activity. Input displayed varying potential vivo self-renewal, with alternative outcomes revealed by single-cell multimodal RNA ATAC sequencing profiling....
A crude extract (B10) of Aspergillus niger spores showed effective antibacterial activity against Agrobacterium tumefaciens T-37. The inhibition rate was 98.22%, and the half maximal inhibitory concentration 0.035 ± 0.018 mg/mL. To study primary mechanism, this used relative electric conductivity, release proteins nucleic acids, sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS–PAGE) detection reactive oxygen species (ROS). After adding B10, conductivity increased in...
Exposure to a harsh ovarian microenvironment induced by chemotherapeutic agents seriously affects the remodeling of function and follicular development, leading premature failure or insufficiency (POF/POI). For decades, effectiveness stem cell therapies in POI animal models has been intensively studied; however, strategies enhance therapeutic effect cells remain challenging.In this study, we first observed pathological changes ovaries at different time points during chemotherapy, including...
Epigenetic mechanisms are gatekeepers for the gene expression patterns that establish and maintain cellular identity in mammalian development, stem cells adult homeostasis. Amongst many epigenetic marks, methylation of histone 3 lysine 4 (H3K4) is one most widely conserved occupies a central position expression. Mixed lineage leukemia 1 (MLL1/KMT2A) founding H3K4 methyltransferase. It was discovered as causative mutation early onset subsequently found to be required establishment definitive...
The scarcity of hematopoietic stem cells (HSCs) restricts their use in both clinical settings and experimental research. Here, we examined a recently developed method for expanding rigorously purified murine HSCs ex vivo. After three weeks culture, only 0.1% exhibited the input HSC phenotype, but these accounted almost all functional long-term activity. Input displayed varying potential vivo self-renewal, with alternative outcomes revealed by single cell multimodal RNA- ATAC-seq profiling....