A5101595735- Gout, Hyperuricemia, Uric Acid
- Microbial infections and disease research
- Schizophrenia research and treatment
- Kidney Stones and Urolithiasis Treatments
- Demographic Trends and Gender Preferences
- Muscle and Compartmental Disorders
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- Polysaccharides and Plant Cell Walls
- Bipolar Disorder and Treatment
- Biomedical Research and Pathophysiology
- Chronic Disease Management Strategies
- Diabetes Management and Education
- Liver Disease Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Family Dynamics and Relationships
- Parathyroid Disorders and Treatments
- Pregnancy and preeclampsia studies
- Tryptophan and brain disorders
- Food composition and properties
- Global Maternal and Child Health
- Urticaria and Related Conditions
- Neurological and metabolic disorders
- Iron Metabolism and Disorders
- Sodium Intake and Health
Capital Medical University
2022-2025
Sichuan University
2023-2025
Beijing Chaoyang Emergency Medical Center
2025
First Affiliated Hospital of Xi'an Jiaotong University
2018-2023
Peking University
2017-2022
Ludwig-Maximilians-Universität München
2020-2022
Beijing Chao-Yang Hospital
2022
LMU Klinikum
2017-2021
Zhengzhou University
2021
Jilin University
2014-2017
The coronavirus disease 2019 (COVID-19) pandemic is the defining global health crisis of our time and greatest challenge facing world. Meteorological parameters are reportedly crucial factors affecting respiratory infectious epidemics; however, effect meteorological on COVID-19 remains controversial. This study investigated effects temperature relative humidity daily new cases deaths COVID-19, which has useful implications for policymakers public. Daily data conditions, were collected 166...
Significance Statement The role of asymptomatic hyperuricemia in the progression CKD has been unclear due to lack animal models with clinically relevant uric acid (UA) levels. A new mouse model reveals that persistent (approximately 15 mg/dl) does not cause CKD, nor accelerate progression, unless UA crystallizes acidic tubular fluid. Crystallization initially causes injury, inflammation, and interstitial fibrosis, subsequently granulomatous nephritis perilesional proinflammatory M1-like...
What proportion of people want to have a second or third child after the enactment three-child policy in China?Under policy, fertility intention was ∼60% (56% women vs 65% men), and 13% (10% 17% men) among Chinese population.The government announced on 31 May 2021, allowing all couples up three children. At present, there is lack national surveys intentions men under China.In June cross-sectional survey including 9243 respondents aged 18-49 years conducted online from provinces China's...
Neutrophils are key players during host defense and sterile inflammation. Neutrophil dysfunction is a characteristic feature of the acquired immunodeficiency kidney disease. We speculated that impaired renal clearance intrinsic purine metabolite soluble uric acid (sUA) may account for neutrophil dysfunction. Indeed, hyperuricemia (HU, serum UA 9-12 mg/dL) related or unrelated to significantly diminished adhesion extravasation in mice with crystal- coronavirus-related inflammation using...
Sodium glucose transporter (SGLT)-2 inhibition has renoprotective effects in diabetic kidney disease. Whether similar can be achieved also non-diabetic disease is speculative. Chronic was induced C57BL/6N mice by feeding an oxalate-rich diet for 14 days, known to induce nephrocalcinosis-related tubular atrophy and interstitial fibrosis without directly affecting the glomerular compartment. Empagliflozin treatment started from day 0 of oxalate had no effect on decline filtration rate, crystal...
Although monosodium urate (MSU) crystals are known to trigger inflammation, published data on soluble uric acid (sUA) in this context discrepant. We hypothesized that diverse sUA preparation methods account for discrepancy and an animal model with clinically relevant levels of asymptomatic hyperuricemia gouty arthritis can ultimately clarify issue. To test this, we cultured human monocytes different solutions found solubilizing (UA) by prewarming created erroneous results because UA...
Abstract Background Globally, the prevalence of anemia among women reproductive age is about 29.4%, and impacts 40% pregnant more than 20% non-pregnant women. We conducted a longitudinal observational study in women, analyzed association between sociodemographic characteristics southwest China. Methods This was which involved 640,672 aged 18–49 years from 129 counties Data were databases National Free Preconception Health Examination Project (NFPHEP) electronic medical records local...
Background: There are few data on the comorbidity of diabetes in Chinese patients with depression. We aimed to calculate prevalence and explore risk factors type 2 mellitus (T2DM) among depression inpatients from 2005 2018 Beijing. Methods: This study is a cross-sectional study. The collected 19 specialized psychiatric hospitals Beijing were analyzed. T2DM its distribution multivariable logistic regression was performed T2DM. Results: A total 20,899 included. 9.13% [95% confidence interval...
Laparoscopic repair as an alternative option for pediatric inguinal hernia has increased worldwide. We aimed to analyze the surgical methods of among children, adolescents and young adults, evaluate outcomes reoperation postoperative complications. This is a hospital-based retrospective cohort study. 3249 inpatients who were ≤ 25 years underwent between 2015 2021 included. Baseline data, characteristics, approach technique, including complications before discharge identified from electronic...
To further optimize birth policy, China implemented a new three-child policy to allow per couple have up three children on May 31, 2021.A national cross-sectional survey was conducted among 18 49-year-old Chinese parents who had at least one child in June 2021. We calculated the prevalence of self-reported childrearing barriers and used univariate logistic regression multivariate analyze associated factors.94.7% respondents rearing aged 0-3 years, biggest barrier included high time cost...
Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation growth, e.g. intrarenal calcium oxalate (CaOx) formation, common cause kidney stone disease nephrocalcinosis-related chronic (CKD). We hypothesized that immunoglobulins can modulate microcrystal growth therefore, biological IgG-based drugs designed to specifically target modifying...
China's one-child policy was replaced by a new universal two-child in 2015; however, few studies have addressed the intent to second child and resulting related issues.
Abstract Background and Purpose Non-alcoholic fatty liver disease (NAFLD) is becoming the most common in China. However, understanding of NAFLD prevalence among Chinese mental disorder inpatients remains insufficient. We aim to investigate Beijing, Methods In this observational study, we included 66,273 between 2014 2018, including with schizophrenia, bipolar disorder, depressive other disorders. Data were obtained from electronic health records 19 specialized psychiatric hospitals Beijing....
ABSTRACT Porcine contagious pleuropneumonia, caused by Actinobacillus pleuropneumoniae , has a major impact on economics, ecology, and animal welfare in the pig-rearing industry. Propionibacterium acnes facultative anaerobic Gram-positive corynebacterium, exists widely normal healthy adult animals. We have shown previously that P. can prevent A. infections mice pigs. To elucidate mechanism of this effect to identify novel vaccines, role anti- antibodies preventing infection was analyzed...
Globally, severe anemia impacts millions of non-pregnant women. However, studies on the prevalence through large epidemiologic surveys among women have been scarce in China. In this study, we aimed to study and its determinants living rural areas Data were gathered for 712,101 aged between 21 49 years who attended 2012 National Free Preconception Health Examination Project. Severe was defined as a hemoglobin (Hb) concentration lower than 80 g/L. Associated factors analyzed using univariate...
Ion-exchange resins are commonly used to manage complications of chronic kidney disease, such as hyperphosphatemia, hyperkalemia, and hypercholesterolemia. Occasionally, these drugs can irritate the gastrointestinal lining cause life-threatening intestinal necrosis. Currently, pathophysiology drug crystal-induced necrosis is not well understood. We hypothesized that crystals ion-exchange like sevelamer, polystyrene sulfonate, cholestyramine trigger formation neutrophil monocyte extracellular...
Acute organ injury, such as acute kidney injury (AKI) and disease (AKD), are major causes of morbidity mortality worldwide. Hyperuricemia (HU) is common in patients with impaired function but the impact asymptomatic HU on different phases AKI/AKD incompletely understood. We hypothesized that would attenuate AKD because soluble, contrast to crystalline, uric acid (sUA) can sterile inflammation. In vitro, 10 mg/dL sUA decreased reactive oxygen species interleukin-6 production macrophages,...
Abstract Background Hiatal hernias negatively damage patients’ health and life quality. Laparoscopic hiatal hernia repair is currently the gold standard for treatment of (LHHR). Numerous clinical trials on laparoscopic have been done, but published findings are highly variable due to lack unique outcome sets. Basic sets ever established over previous decade a few procedures, not yet. This protocol outlines procedure develop core set COS-LHHR). COS-LHHR will provide criteria investigations....
Objective We aim to investigate the prevalence, trends, and major risk factors of type 2 diabetes mellitus (T2DM) among adult psychiatric inpatients in Beijing, China. Research design methods did a longitudinal observational study using data from Beijing Municipal Commission Health Family Planning Information Center, including 157 570 19 specialized hospitals 2005 2018 Beijing. Data on demographic characteristics antipsychotic medication use were obtained electronic health records....